Results 51 to 60 of about 805,322 (205)
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Revista Colombiana de Obstetricia y Ginecología, 2007 Debido a la rara presentación simultánea entre cáncer y embarazo y a que la afectación de la unidad fetoplacentaria por dicha patología es aún más exótica, la presente revisión busca lograr un mejor entendimiento sobre la afectación placentaria y fetal ...
Eugenia Corredor-Sánchez +1 more
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YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Revista Cubana de Investigaciones Biomédicas, 2010 La metástasis es la rápida proliferación de células de cáncer, tumor secundario, en un sitio específico, que, en general, conduce a la muerte. Este proceso ocurre en sitios anatómicos que proveen el ambiente necesario de vascularización, oxígeno y ...
Diego Alexander Garzón-Alvarado +2 more
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Connotas. Revista de Crítica y Teoría Literarias, 2020 En el presente artículo se propone que, en Operación al cuerpo enfermo de Sergio Loo, se produce una metástasis literaria debido a la falta de límites corporales tanto entre los personajes como a nivel textual, por lo que la obra crea su propia realidad ...
Nora Renée Muñiz Hernández
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Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Melanoma amelanótico diseminado
Revista Cubana de Medicina, 2021 RESUMEN El melanoma amelanótico es una de las neoplasias con mayor índice de mortalidad por su alta agresividad y baja probabilidad diagnóstica. Afecta a la población de todo el orbe, más frecuente en caucásicos, con predisposición genética y factores de
Karen Valdés Alvarez +2 more
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