Results 121 to 130 of about 10,961 (170)
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Met-enkephalin receptors in human gliomas
NeuroReport, 1994Endogenous opioid systems (opioid peptides and receptors) are involved in many functions including the regulation of cell growth. We investigated the presence of Met-enkephalin binding sites in gliomas by displacement assays. Results demonstrated that few gliomas exhibit Met-enkephalin binding sites and that the percentage of tumours which express ...
L, Molin +3 more
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Smart Polymeric Nanocarriers of Met-enkephalin
Biomacromolecules, 2016This study describes a novel approach to polymeric nanocarriers of the therapeutic peptide met-enkephalin based on the aggregation of thermoresponsive polymers. Thermoresponsive bioconjugate poly((di(ethylene glycol) monomethyl ether methacrylate)-ran-(oligo(ethylene glycol) monomethyl ether methacrylate) is synthesized by AGET ATRP using modified met ...
Roza, Szweda +8 more
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Met-enkephalin circulates in human plasma
Nature, 1980The physiological roles of Met-enkephalin and Leu-enkephalin are still unknown. They may act as neurotransmitters in the central and peripheral nervous systems. Met-enkephalin has been detected in several species in a variety of tissues including brain, spinal cord and gut using bioassays, opiate receptor assays and radioimmunoassays (RIA). It has also
V, Clement-Jones +3 more
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Interaction of Met‐Enkephalin with Human Granulocytes
Annals of the New York Academy of Sciences, 1987Met-enkephalin has been found to have an effect on cell shape and motility of human polymorphonuclear leukocytes (PMNs). Specific binding of tritium-labeled Met-enkephalin to the cells could not be demonstrated. There was a rapid proteolytic degradation of the peptide in the medium, followed by uptake of the labeled tyrosine.
E G, Fischer, N E, Falke
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Met-enkephalin immunoreactivity in blood platelets
Life Sciences, 1982Picogram amounts (50-150 pg/mg protein) of immunoreactive met-enkephalin material (met-enkephalin IR) were detected by radioimmunoassay in human, rat and rabbit platelets. Characterization of this material by thin-layer chromatography, gel filtration chromatography and high-pressure liquid chromatography indicated that it behaves identically with ...
A.M. Di Giulio +4 more
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Biochemical and Biophysical Research Communications, 1981
Abstract Enzymes degrading Met-enkephalin-Arg 6 -Phe 7 , an endogenous brain peptide with enhanced opiate activity in vivo, were isolated from membrane preparations of rabbit kidney and brain, and their specificity compared. A preparation from kidney or brain containing the angiotensin converting enzyme (EC 3.4.15.1) released with time Arg-Phe, Met ...
M, Benuck, M J, Berg, N, Marks
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Abstract Enzymes degrading Met-enkephalin-Arg 6 -Phe 7 , an endogenous brain peptide with enhanced opiate activity in vivo, were isolated from membrane preparations of rabbit kidney and brain, and their specificity compared. A preparation from kidney or brain containing the angiotensin converting enzyme (EC 3.4.15.1) released with time Arg-Phe, Met ...
M, Benuck, M J, Berg, N, Marks
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Met-Enkephalin in Oxidative Stress
2006Hugo Besedovsky demonstrated immune-brain communications more than 35 years ago. His recent findings concern the ability of IL-1 (centrally mediated immune challenge) to induce hypoglycaemia (response of immune tissue on periphery). So we no longer question that injection of immune modulators can affect the brain or that the immune system can interfere
Haberstock-Debić, Helena +4 more
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Cell and Tissue Research, 1985
Region-specific antisera to three enkephalins: met-enkephalin, met-enkephalin-Arg6-Phe7 and met-enkephalin-Arg6-Gly7-Leu8, together with four region specific antisera to progastrin: C-terminal G17 specific, N-terminal G34 specific, cryptic peptides A- and B-specific, were used in immunohistochemical studies of hog antral mucosa. A sub-population (6-10%)
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Region-specific antisera to three enkephalins: met-enkephalin, met-enkephalin-Arg6-Phe7 and met-enkephalin-Arg6-Gly7-Leu8, together with four region specific antisera to progastrin: C-terminal G17 specific, N-terminal G34 specific, cryptic peptides A- and B-specific, were used in immunohistochemical studies of hog antral mucosa. A sub-population (6-10%)
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Enzymatic synthesis of Leu- and Met-enkephalin
Biochemical and Biophysical Research Communications, 1979Abstract The protease-catalyzed synthesis of Leu- and Met-enkephalin is reported. Each peptide bond of the endogeneous opiate-pentapeptides was formed either by papain or α-chymotrypsin catalysis. N-acyl amino acids and peptides or their ester derivatives served as substrates whereas amino acid and peptide phenylhydrazides were used as nucleophiles ...
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Biochemical and Biophysical Research Communications, 1982
Abstract High performance liquid chromatography (HPLC) coupled with specific radioimmunoassays for methionine-enkephalin-Arg6-Gly7-Leu8 (Met-E-Arg6-Gly7-Leu8), methionine-enkephalin (Met-E), leucine-enkephalin (Leu-E) and methionine-enkephalin-Arg6-Phe7 (Met-E-Arg6-Phe7) has demonstrated that Met-E-Arg6-Gly7-Leu8 exists together with Met-E, Leu-E and
Y, Ikeda +5 more
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Abstract High performance liquid chromatography (HPLC) coupled with specific radioimmunoassays for methionine-enkephalin-Arg6-Gly7-Leu8 (Met-E-Arg6-Gly7-Leu8), methionine-enkephalin (Met-E), leucine-enkephalin (Leu-E) and methionine-enkephalin-Arg6-Phe7 (Met-E-Arg6-Phe7) has demonstrated that Met-E-Arg6-Gly7-Leu8 exists together with Met-E, Leu-E and
Y, Ikeda +5 more
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