Results 11 to 20 of about 3,357 (158)

Targeted and untargeted metabolomics and lipidomics in dried blood microsampling: Recent applications and perspectives

Analytical Science Advances
Blood microsampling (BµS) offers an alternative to conventional methods that use plasma or serum for profiling human health, being minimally invasive and cost effective, especially beneficial for vulnerable populations. We present a non‐systematic review
Pauline Couacault, Dennisse Avella, Sara Londoño‐Osorio, Ana S. Lorenzo, Ana Gradillas, Olli Kärkkäinen, Elizabeth Want, Michael Witting   +7 more
doaj   +2 more sources

Multiomic Integration Analysis for Monitoring Severe Asthma Treated With Mepolizumab or Omalizumab. [PDF]

Allergy
Mepolizumab and omalizumab induce a distinct clinical effect. Mepolizumab and omalizumab induce both common and treatment‐specific metabolic and protein profiles over time in patients with severe asthma. Multiomic integration and receiver operating characteristic curve analyses reveal a specific set of biomolecules suggesting their value as potential ...
Contreras N, Escolar-Peña A, Delgado-Dolset MI, Fernández P, Obeso D, Izquierdo E, Cuervo HG, Cumplido JÁ, Múgica V, Cisneros C, Angulo-Díaz-Parreño S, Barbas C, Blanco C, Carrillo T, Barber D, Villaseñor A, Escribese MM.   +16 more
europepmc   +2 more sources

A Covalent and Modulable Inhibitor of the Tubulin-Microtubule System: Insights Into the Mechanism of Cacalol. [PDF]

Chem Biol Drug Des
An oxidated form of cacalol, the methylenecyclohexadienone MTC (2), is generated under highly oxidant conditions, thus emulating the environment present in cancer cells. This species (2) is responsible for the inhibition of tubulin polymerization by promoting an irreversible binding interaction with Cys347 in α‐tubulin.
López-López E, Medina-Franco JL, Salinas-Arellano E, Ardila-Fierro KJ, Pardo-Novoa JC, Del Río RE, Cerda-García-Rojas CM.   +6 more
europepmc   +2 more sources

Characterisation of Sclerocarya birrea (marula) seed oil and investigation of the geographical origin by applying similarity calculations, differential NMR and hierarchical cluster analysis

Phytochemical Analysis, Volume 34, Issue 8, Page 959-969, December 2023., 2023
Abstract Introduction The marula fruit is an important indigenous African fruit since various commercial products are produced from the pulp and the seed oil. The increased demand requires methods for authentication, quality control and determination of geographical origin.
Jan Schripsema, Wilma Augustyn, Alvaro Viljoen   +2 more
wiley   +1 more source

Ecological convergence in phytochemistry and flower–insect visitor interactions along an Andean elevation gradient

Ecology and Evolution, Volume 13, Issue 8, August 2023., 2023
In this study, we detected patterns of ecological convergence along elevation in floral volatiles as well as cost–benefit ratio in seed versus pollinated seeds. Our results suggest that these evolutionary patterns are the result of biotic and abiotic pressures.
Alma Nalleli Carvajal Acosta, Ludovico Formenti, Adrienne Godschalx, Angelos Katsanis, Constanza Schapheer, Kailen Mooney, Cristian Villagra, Sergio Rasmann   +7 more
wiley   +1 more source

Deciphering the role of platelets in severe allergy by an integrative omics approach

Allergy, Volume 78, Issue 5, Page 1319-1332, May 2023., 2023
This study analyzes the lipidomic and transcriptomic profile of platelets in patients with mild and severe allergy. The lipidomic profile of platelets form severe allergic patients shows high levels of ceramides, phosphoinositols, phosphocholines, and sphingomyelins and low levels of arachidonic acid.
Carmela Pablo‐Torres, Elena Izquierdo, Tiak Ju Tan, David Obeso, Janice A. Layhadi, Javier Sánchez‐Solares, Leticia Mera‐Berriatua, José Luis Bueno‐Cabrera, María del Mar Reaño‐Martos, Alfredo Iglesias‐Cadarso, Coral Barbas, Cristina Gomez‐Casado, Alma Villaseñor, Domingo Barber, Mohamed H. Shamji, María M. Escribese   +15 more
wiley   +1 more source

Profiling of polar ionogenic metabolites in Polish wines by capillary electrophoresis‐mass spectrometry

ELECTROPHORESIS, Volume 43, Issue 18-19, Page 1814-1821, October 2022., 2022
Abstract The composition of wine is determined by a complex interaction between environmental factors, genetic factors (i.e., grape varieties), and winemaking practices (including technology and storage). Metabolomics using NMR spectroscopy, GC‐MS, and/or LC‐MS has shown to be a useful approach for assessing the origin, authenticity, and quality of ...
Marlien van Mever, Magdalena Fabjanowicz, Maricruz Mamani‐Huanca, Ángeles López‐Gonzálvez, Justyna Płotka‐Wasylka, Rawi Ramautar   +5 more
wiley   +1 more source

Structural Insights into the HWE Histidine Kinase Family: The Brucella Blue Light-Activated Histidine Kinase Domain [PDF]

, 2016
In response to light, as part of a two-component system, the Brucella blue light-activated histidine kinase (LOV-HK) increases its autophosphorylation, modulating the virulence of this microorganism.
Arrar, Mehrnoosh, Berguer, Paula Mercedes, Cerutti, Maria Laura, Estrin, Dario Ariel, Goldbaum, Fernando Alberto, Klinke, Sebastian, Marti, Marcelo Adrian, Paris, Gastón, Rinaldi, Jimena Julieta, Sycz, Gabriela   +9 more
core   +1 more source

(DES)CONSTRUINDO A METABOLÔMICA EM PRODUTOS NATURAIS: UM CONVITE A DISCUSSÃO

Química Nova, 2021
The metabolomics approach is widespread and accepted in several lines within life sciences. However, much of what has been called metabolomics could be better defined as a comparison study, regardless of its purpose.
Ricardo Moreira Borges, João Victor Mendes Resende   +1 more
doaj   +1 more source

Aplicaciones de la metabolómica

Revista Española de Nutrición Humana y Dietética, 2020
III Congreso de Alimentación, Nutrición y Dietética. Combinar la nutrición comunitaria y personalizada: nuevos retos.
Tania Portoles, Leticia Lacalle-Bergeron, David Izquierdo, Juan V Sancho, Maria Puy, Alfredo Fernández   +5 more
doaj   +2 more sources