Results 11 to 20 of about 3,317 (156)

Targeted and untargeted metabolomics and lipidomics in dried blood microsampling: Recent applications and perspectives

Analytical Science Advances
Blood microsampling (BµS) offers an alternative to conventional methods that use plasma or serum for profiling human health, being minimally invasive and cost effective, especially beneficial for vulnerable populations. We present a non‐systematic review
Pauline Couacault, Dennisse Avella, Sara Londoño‐Osorio, Ana S. Lorenzo, Ana Gradillas, Olli Kärkkäinen, Elizabeth Want, Michael Witting   +7 more
doaj   +2 more sources

Multiomic Integration Analysis for Monitoring Severe Asthma Treated With Mepolizumab or Omalizumab. [PDF]

Allergy
Mepolizumab and omalizumab induce a distinct clinical effect. Mepolizumab and omalizumab induce both common and treatment‐specific metabolic and protein profiles over time in patients with severe asthma. Multiomic integration and receiver operating characteristic curve analyses reveal a specific set of biomolecules suggesting their value as potential ...
Contreras N, Escolar-Peña A, Delgado-Dolset MI, Fernández P, Obeso D, Izquierdo E, Cuervo HG, Cumplido JÁ, Múgica V, Cisneros C, Angulo-Díaz-Parreño S, Barbas C, Blanco C, Carrillo T, Barber D, Villaseñor A, Escribese MM.   +16 more
europepmc   +2 more sources

A Covalent and Modulable Inhibitor of the Tubulin-Microtubule System: Insights Into the Mechanism of Cacalol. [PDF]

Chem Biol Drug Des
An oxidated form of cacalol, the methylenecyclohexadienone MTC (2), is generated under highly oxidant conditions, thus emulating the environment present in cancer cells. This species (2) is responsible for the inhibition of tubulin polymerization by promoting an irreversible binding interaction with Cys347 in α‐tubulin.
López-López E, Medina-Franco JL, Salinas-Arellano E, Ardila-Fierro KJ, Pardo-Novoa JC, Del Río RE, Cerda-García-Rojas CM.   +6 more
europepmc   +2 more sources

Molecular Signatures and Functional Pathways of Human Monocytes and Macrophages in Allergy: An EAACI AllergoOncology Scoping Review. [PDF]

Allergy
ABSTRACT AllergoOncology explores the intersection of allergic diseases and cancer, focusing on shared immune mechanisms. While monocytes and macrophages are extensively studied in cancer, their roles in allergic diseases remain underexplored. To address this gap, we conducted a scoping review to systematically characterize the molecular landscape and ...
Bianchini R, Escolar-Peña A, Pick V, Poli A, Adams R, Basilio J, Cari L, Chauhan J, Chivato T, Vecillas LL, Delgado-Dolset MI, Escribese MM, Grandits M, Bax HJ, Martín-Antoniano IA, Martín-Cruz L, Mayerhofer H, Michelucci A, Nocentini G, Osborn G, Pablo-Torres C, Palomares O, Pascal M, Radzikowska U, Rohr-Udilova N, Sokolowska M, Bergmann C, Jensen-Jarolim E, Karagiannis SN, Rebollido-Rios R, Izquierdo E.   +30 more
europepmc   +2 more sources

Characterisation of Sclerocarya birrea (marula) seed oil and investigation of the geographical origin by applying similarity calculations, differential NMR and hierarchical cluster analysis

Phytochemical Analysis, Volume 34, Issue 8, Page 959-969, December 2023., 2023
Abstract Introduction The marula fruit is an important indigenous African fruit since various commercial products are produced from the pulp and the seed oil. The increased demand requires methods for authentication, quality control and determination of geographical origin.
Jan Schripsema, Wilma Augustyn, Alvaro Viljoen   +2 more
wiley   +1 more source

Ecological convergence in phytochemistry and flower–insect visitor interactions along an Andean elevation gradient

Ecology and Evolution, Volume 13, Issue 8, August 2023., 2023
In this study, we detected patterns of ecological convergence along elevation in floral volatiles as well as cost–benefit ratio in seed versus pollinated seeds. Our results suggest that these evolutionary patterns are the result of biotic and abiotic pressures.
Alma Nalleli Carvajal Acosta, Ludovico Formenti, Adrienne Godschalx, Angelos Katsanis, Constanza Schapheer, Kailen Mooney, Cristian Villagra, Sergio Rasmann   +7 more
wiley   +1 more source

Deciphering the role of platelets in severe allergy by an integrative omics approach

Allergy, Volume 78, Issue 5, Page 1319-1332, May 2023., 2023
This study analyzes the lipidomic and transcriptomic profile of platelets in patients with mild and severe allergy. The lipidomic profile of platelets form severe allergic patients shows high levels of ceramides, phosphoinositols, phosphocholines, and sphingomyelins and low levels of arachidonic acid.
Carmela Pablo‐Torres, Elena Izquierdo, Tiak Ju Tan, David Obeso, Janice A. Layhadi, Javier Sánchez‐Solares, Leticia Mera‐Berriatua, José Luis Bueno‐Cabrera, María del Mar Reaño‐Martos, Alfredo Iglesias‐Cadarso, Coral Barbas, Cristina Gomez‐Casado, Alma Villaseñor, Domingo Barber, Mohamed H. Shamji, María M. Escribese   +15 more
wiley   +1 more source

Profiling of polar ionogenic metabolites in Polish wines by capillary electrophoresis‐mass spectrometry

ELECTROPHORESIS, Volume 43, Issue 18-19, Page 1814-1821, October 2022., 2022
Abstract The composition of wine is determined by a complex interaction between environmental factors, genetic factors (i.e., grape varieties), and winemaking practices (including technology and storage). Metabolomics using NMR spectroscopy, GC‐MS, and/or LC‐MS has shown to be a useful approach for assessing the origin, authenticity, and quality of ...
Marlien van Mever, Magdalena Fabjanowicz, Maricruz Mamani‐Huanca, Ángeles López‐Gonzálvez, Justyna Płotka‐Wasylka, Rawi Ramautar   +5 more
wiley   +1 more source

Development of a Hepatoprotective Herbal Drug from Turnera diffusa

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
The incidence of liver diseases, such as nonalcoholic fatty liver disease and drug‐induced liver injury, continues to rise and is one of the leading causes of acute hepatitis. Current trends suggest that these types of conditions will increase in the coming years.
Cecilia Delgado-Montemayor, Paula Cordero-Pérez, Liliana Torres-González, María de la L. Salazar-Cavazos, Alma L. Saucedo, David Paniagua-Vega, Noemí H. Waksman-Minsky, Hamid Tebyaniyan   +7 more
wiley   +1 more source

INSIGHTS SOBRE TROMBOEMBOLISMO VENOSO (TEV) E SÍNDROME DO ANTICORPO ANTIFOSFOLÍPIDE (SAF) POR 1H-NMR

Hematology, Transfusion and Cell Therapy, 2023
Introdução: A SAF é uma doença sistêmica imunomediada caracterizada por trombose arterial ou venosa recorrente ou morbidades obstétricas acompanhadas por anticorpos antifosfolipídeos.
LG Martins, BM Manzini, SA Montalvão, MA Honorato, SC Huber, F Orsi, ES Braga, N Avramovic, L Tasic, JM Annichino-Bizzacchi   +9 more
doaj   +1 more source