Results 1 to 10 of about 347 (99)

Obesity and anesthetic pharmacology: simulation of target-controlled infusion models of propofol and remifentanil [PDF]

Korean Journal of Anesthesiology, 2021
The prevalence of obesity is increasing, resulting in an increase in the number of surgeries performed to treat obesity and diseases induced by obesity. The associated comorbidities as well as the pharmacokinetic and pharmacodynamic changes that occur in
Tae Kyun Kim
doaj   +1 more source

Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs. [PDF]

PLoS ONE, 2018
Two chemotypes were examined in vitro with CYPs 3A4 and 2C19 by molecular docking, metabolic profiles, and intrinsic clearance deuterium isotope effects with specifically deuterated form to assess the potential for enhancement of pharmacokinetic ...
Hao Sun, David W Piotrowski, Suvi T M Orr, Joseph S Warmus, Angela C Wolford, Steven B Coffey, Kentaro Futatsugi, Yinsheng Zhang, Alfin D N Vaz   +8 more
doaj   +1 more source

Short-Term SGLT2 Inhibitor Administration Does Not Alter Systemic Insulin Clearance in Type 2 Diabetes

Biomedicines, 2021
Background: Decreased insulin clearance could be a relatively upstream abnormality in obesity, metabolic syndrome, and nonalcoholic fatty liver disease. Previous studies have shown that sodium-glucose cotransporter 2 inhibitor (SGLT2i) increases insulin ...
Motonori Sato, Yoshifumi Tamura, Hideyoshi Kaga, Nozomu Yamasaki, Mai Kiya, Satoshi Kadowaki, Daisuke Sugimoto, Takashi Funayama, Yuki Someya, Saori Kakehi, Shuko Nojiri, Hiroaki Satoh, Ryuzo Kawamori, Hirotaka Watada   +13 more
doaj   +1 more source

Determination of the delivered hemodialysis dose using standard methods and on-line clearance monitoring [PDF]

Vojnosanitetski Pregled, 2006
Background/aim: Delivered dialysis dose has a cumulative effect and significant influence upon the adequacy of dialysis, quality of life and development of co-morbidity at patients on dialysis.
Vlatković Vlastimir, Stojimirović Biljana   +1 more
doaj   +1 more source

Variable Capacity for Acute and Chronic Thermal Compensation of Physiological Rates Contributes to Inter-Individual Differences in Growth Rate in Mussels (Mytilus galloprovincialis)

Frontiers in Marine Science, 2020
The aim of this study was to ascertain if the capacity for acute and chronic compensation of thermal effects on physiological rates represents a trait contributing to inter-individual growth rate differences in the mussel Mytilus galloprovincialis ...
Daniel Prieto, Kristina Arranz, Iñaki Urrutxurtu, Enrique Navarro, Miren Bego Urrutia, Irrintzi Ibarrola   +5 more
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Bile acid sequestration reduces plasma glucose levels in db/db mice by increasing its metabolic clearance rate. [PDF]

PLoS ONE, 2011
AIMS/HYPOTHESIS: Bile acid sequestrants (BAS) reduce plasma glucose levels in type II diabetics and in murine models of diabetes but the mechanism herein is unknown.
Maxi Meissner, Hilde Herrema, Theo H van Dijk, Albert Gerding, Rick Havinga, Theo Boer, Michael Müller, Dirk-Jan Reijngoud, Albert K Groen, Folkert Kuipers   +9 more
doaj   +1 more source

Metabolic Clearance and Production Rates of Human Thyrotropin [PDF]

Journal of Clinical Investigation, 1974
Metabolic clearance (MCR) and production rates (PR) of human thyrotropin (hTSH) were determined by the constant infusion to equilibrium method 57 times in 55 patients. 16 control patients had a mean hTSH MCR of 50.7 ml/min. The mean hTSH MCR was significantly (P < 0.02) higher in 19 euthyroid men (51.6 ml/min) than in 12 euthyroid women (43.0 ml/min ...
E C, Ridgway, B D, Weintraub, F, Maloof
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Insulin Clearance Is Associated with Hepatic Lipase Activity and Lipid and Adiposity Traits in Mexican Americans. [PDF]

PLoS ONE, 2016
Reduction in insulin clearance plays an important role in the compensatory response to insulin resistance. Given the importance of this trait to the pathogenesis of diabetes, a deeper understanding of its regulation is warranted. Our goal was to identify
Artak Labadzhyan, Jinrui Cui, Miklós Péterfy, Xiuqing Guo, Yii-Der I Chen, Willa A Hsueh, Jerome I Rotter, Mark O Goodarzi   +7 more
doaj   +1 more source

Long-term high-fat diet increases glymphatic activity in the hypothalamus in mice

Scientific Reports, 2023
Obesity affects millions of people worldwide and is associated with an increased risk of cognitive decline. The glymphatic system is a brain-wide metabolic waste clearance system, dysfunction of which is linked to dementia.
Christine Delle, Neža Cankar, Christian Digebjerg Holgersson, Helle Hvorup Knudsen, Elise Schiøler Nielsen, Celia Kjaerby, Yuki Mori, Maiken Nedergaard, Pia Weikop   +8 more
doaj   +1 more source

Hyperpolarized [1-13C]-acetate Renal Metabolic Clearance Rate Mapping [PDF]

Scientific Reports, 2017
Abstract11C-acetate is a positron emission tomography (PET) tracer of oxidative metabolism, whereas hyperpolarized 13C-acetate can be used in magnetic resonance imaging (MRI) for investigating specific metabolic processes. The aims of this study were to examine if the kinetic formalism of 11C-acetate PET in the kidneys is comparable to that of 13C ...
Emmeli F. R. Mikkelsen, Christian Østergaard Mariager, Thomas Nørlinger, Haiyun Qi, Rolf F. Schulte, Steen Jakobsen, Jørgen Frøkiær, Michael Pedersen, Hans Stødkilde-Jørgensen, Christoffer Laustsen   +9 more
openaire   +2 more sources