Results 11 to 20 of about 172,525 (164)

Developing a metabolic clearance rate framework as a translational analysis approach for hyperpolarized 13C magnetic resonance imaging [PDF]

Scientific Reports, 2023
Hyperpolarized carbon-13 magnetic resonance imaging is a promising technique for in vivo metabolic interrogation of alterations between health and disease.
James T. Grist, Nikolaj Bøgh, Esben Søvsø Hansen, Anna M. Schneider, Richard Healicon, Vicky Ball, Jack J. J. J. Miller, Sean Smart, Yvonne Couch, Alastair M. Buchan, Damian J. Tyler, Christoffer Laustsen   +11 more
doaj   +2 more sources

Mathematical Modeling in Drug Metabolism and Pharmacokinetics: Correct In Vitro, Not Always Valid In Vivo [PDF]

Pharmaceuticals
Background/Objectives: Chemical and metabolic kinetics have historically been derived from mass balance differential equations expressed in terms of amounts, and this framework was later extended to pharmacokinetics by converting amount-based equations ...
Leslie Z. Benet, Jasleen K. Sodhi
doaj   +2 more sources

Biotransformation and kinetics of selected benzimidazole synthetic opioids in human hepatocytes [PDF]

Frontiers in Pharmacology
Background/ObjectivesThe reemergence of 2-benzylbenzimidazole opioids, also called nitazenes, in the illicit drug market constitutes a serious threat to public health. One of the major challenges in handling exposures and managing intoxications in humans
Gajanan R. Jadhav, Pius S. Fasinu
doaj   +2 more sources

Comparative Study on Feeding Physiology, Metabolic Physiology, and Energy Budget of Meretrix meretrix, Mactra veneriformis, and Ruditapes philippinarum in the Tidal Flat Aquaculture Zone [PDF]

Animals
(1) Exploring the potential impacts of Mactra veneriformis and Ruditapes philippinarum on the aquaculture of Meretrix meretrix in the tidal flat aquaculture zone is significant for the optimization of bivalve aquaculture structure.
Longyu Liu, Yue Zhu, Chaozhong Xin, Jinmeng Bao, Fengbiao Wang, Shuai Han, Haopeng Hu, Xuan Zhang, Lei Li, Mei Jiang   +9 more
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Effect of Acute Thermal Stress Exposure on Ecophysiological Traits of the Mediterranean Sponge Chondrilla nucula: Implications for Climate Change

Biology, 2023
As a result of climate change, the Mediterranean Sea has been exposed to an increase in the frequency and intensity of marine heat waves in the last decades, some of which caused mass mortality events of benthic invertebrates, including sponges.
Mar Bosch-Belmar, Martina Milanese, Antonio Sarà, Valeria Mobilia, Gianluca Sarà   +4 more
doaj   +1 more source

Metabolic clearance rate of radioiodinated human calcitonin in man [PDF]

Journal of Clinical Investigation, 1970
The characteristics of the disappearance of radioiodinated synthetic human calcitonin from plasma have been studied in man. After single injection the disappearance curve was multiexponential. The number of exponentials of the theoretical curve fitting the best with the experimental data varied individually. Metabolic clearance rate was determined both
R, Ardaillou, P, Sizonenko, A, Meyrier, G, Vallée, C, Beaugas   +4 more
openaire   +2 more sources

Decreased maximal cortisol secretion rate in patients with cirrhosis: Relation to disease severity

JHEP Reports, 2021
Background & Aims: Hepatic enzymes play a major role in the metabolic elimination of cortisol, and reduced rates of cortisol clearance have been consistently observed in patients with chronic liver disease.
Christina M. Lovato, Thierry Thévenot, Sophie Borot, Vincent Di Martino, Clifford R. Qualls, Frank K. Urban, III, Richard I. Dorin   +6 more
doaj   +1 more source

Metabolic clearance rate and production rate of calcitriol in uremia

Kidney International, 1989
We have previously demonstrated that while both normal humans and dogs tightly control serum calcitriol levels after 25(OH)D administration, anephric humans and 5/6 nephrectomized dogs significantly increase circulating 1,25(OH)2D when supraphysiological concentrations of 25(OH)D are reached in serum.
Dusso, Adriana, Lopez-Hilker, Silvia, Lewis-Finch, Jane, Grooms, Patricia, Brown, Alex, Martin, Kevin, Slatopolsky, Eduardo   +6 more
openaire   +2 more sources

Metabolic clearance and production rates of human growth hormone [PDF]

Journal of Clinical Investigation, 1969
The metabolic clearance rate (MCR) of human growth hormone (HGH) was determined by the constant infusion to equilibrium technique utilizing HGH-(125)I. 22 control subjects had a MCR of 229 +/-52 ml/min (mean +/-SD). No difference was evident between sexes, or between various age groups. Patients with acromegaly demonstrated normal MCR's.
A L, Taylor, J L, Finster, D H, Mintz
openaire   +2 more sources

Intraoperative lactate level and lactate clearance is associated with long-term mortality in liver transplant recipients [PDF]

Anesthesia and Pain Medicine
Background Hyperlactatemia has been associated with poor outcomes in various clinical settings including liver transplantation (LT). However, the impact of intraoperative lactate levels and lactate clearance on long-term mortality in LT recipients ...
Akira Katayama, Ezeldeen Abuelkasem, Marianne M. Ligon, Yaroslava Longhitano, David W. Wang   +4 more
doaj   +1 more source