Results 21 to 30 of about 172,525 (164)

Population pharmacokinetic analysis of enrofloxacin and its active metabolite ciprofloxacin after intravenous injection to cats with reduced kidney function

Journal of Veterinary Internal Medicine, 2023
Background It is unknown if enrofloxacin accumulates in plasma of cats with reduced kidney function. Hypothesis To determine if enrofloxacin and its active metabolite ciprofloxacin have reduced clearance in azotemic cats.
Jonathan D. Foster, Mahmoud Abouraya, Mark G. Papich, Nancy A. Muma   +3 more
doaj   +1 more source

Measuring the Pharmacokinetic Properties of Drugs with a Novel Surgical Rat Model

Journal of Investigative Surgery, 2017
Purpose/aim of the study: The pharmacokinetic (PK) parameters in animal models can help optimize novel candidate drugs prior to human trials. However, due to the complexity of pharmacokinetic experiments, their use is limited in academia.
Ioannis Christakis, Rebecca Scott, James Minnion, Joyceline Cuenco, Tricia Tan, Fausto Palazzo, Stephen Bloom   +6 more
doaj   +1 more source

Establishment of the Protocol of Intramuscular 223RaCl2 Injection and the Corresponding Evaluation on Feasibility and Safety

Journal of Isotopes, 2023
223RaCl2 injection for bone metastasis of prostate cancer has been approved for clinical marketing and achieved good clinical effects. However, there are some defects to be solved in the actual use process. Changing the route of drug administration is an
LI Xiaohong;ZUO Changjing;LI Xiao
doaj   +1 more source

A Novel Method for Predicting the Human Inherent Clearance and Its Application in the Study of the Pharmacokinetics and Drug–Drug Interaction between Azidothymidine and Fluconazole Mediated by UGT Enzyme

Pharmaceutics, 2021
In order to improve the benefit–risk ratio of pharmacokinetic (PK) research in the early development of new drugs, in silico and in vitro methods were constructed and improved.
Yawen Yuan, Jun Zhang, Boyu Fang, Xiaoqiang Xiang, Guo Ma, Shunguo Zhang, Bin Zhu, Weimin Cai   +7 more
doaj   +1 more source

Metabolic Clearance Rate of Oxytocin in Human Subjects

Folia Endocrinologica Japonica, 1989
Oxytocin metabolism seems to occur mainly in the kidney and the liver. Placental cystine amino peptidase (CAP), which inactivates oxytocin by cleavage of the bond between the N-terminal cystine residue and adjacent tyrosine, rises progressively with advancing gestation. The role of CAP in oxytocin metabolism is not clear.
S, Takeda, Y, Kuwabara, M, Mizuno
openaire   +3 more sources

Aging-Related Alterations of Glymphatic Transport in Rat: In vivo Magnetic Resonance Imaging and Kinetic Study

Frontiers in Aging Neuroscience, 2022
ObjectiveImpaired glymphatic waste clearance function during brain aging leads to the accumulation of metabolic waste and neurotoxic proteins (e.g., amyloid-β, tau) which contribute to neurological disorders.
Lian Li, Guangliang Ding, Li Zhang, Esmaeil Davoodi-Bojd, Michael Chopp, Michael Chopp, Qingjiang Li, Zheng Gang Zhang, Quan Jiang   +8 more
doaj   +1 more source

Metabolic clearance rate of radioiodinated human growth hormone in man [PDF]

Journal of Clinical Investigation, 1969
The nature of the disappearance of radioiodinated human growth hormone (HGH) from plasma has been reexamined. The metabolic clearance rate (MCR) was determined both from single injection and constant infusion studies. After single injection of highly purified radioiodinated HGH, the disappearance curve remained multiexponential during the period of ...
D P, Cameron, H G, Burger, K J, Catt, A, Doig   +3 more
openaire   +2 more sources

Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue.

PLoS Biology, 2019
Beiging of white adipose tissue (WAT) is a particularly appealing target for therapeutics in the treatment of metabolic diseases through norepinephrine (NE)-mediated signaling pathways.
Wenxin Song, Qi Luo, Yuping Zhang, Linkang Zhou, Ye Liu, Zhilong Ma, Jianan Guo, Yuedong Huang, Lili Cheng, Ziyi Meng, Zicheng Li, Bin Zhang, Siqi Li, Sook Wah Yee, Hao Fan, Peng Li, Kathleen M Giacomini, Ligong Chen   +17 more
doaj   +1 more source

Population pharmacokinetic model with time‐varying clearance for lorlatinib using pooled data from patients with non‐small cell lung cancer and healthy participants

CPT: Pharmacometrics & Systems Pharmacology, 2021
Lorlatinib, a selective inhibitor of anaplastic lymphoma kinase (ALK) and c‐ROS oncogene 1 (ROS1) tyrosine kinase, is indicated for the treatment of ALK‐positive metastatic non‐small cell lung cancer (NSCLC) following progression on crizotinib and at ...
Joseph Chen, Brett Houk, Yazdi K. Pithavala, Ana Ruiz‐Garcia   +3 more
doaj   +1 more source

Clearance tests to assess liver function state of animals using compounds with high hepatic metabolism [PDF]

E3S Web of Conferences
The article is devoted to the study of the medicinal substances metabolism in the liver and the possibility of using clearance tests with lidocaine and caffeine in veterinary medicine. It has been established that liver is the main organ where metabolism
Ponamarev Vladimir, Popova Olga, Kostrova Anastasia, Agafonova Ludmila   +3 more
doaj   +1 more source