Results 151 to 160 of about 1,774 (249)

Monoaminylation in Human Health and Disease: State of the Field, Challenges, and Emerging Directions

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This review delineates monoaminylation—serotonylation, dopaminylation, and histaminylation—as key post‐translational modifications beyond receptor signaling. It details their catalytic mechanisms, roles in gene expression and protein function, and implications in health and disease, aiming to bridge mechanistic insights with therapeutic potential ...
Yiqi Zhao, Hongli Zhang, Yating Yang, Wei‐Dong Chen, Yan‐Dong Wang   +4 more
wiley   +1 more source

Assessment of chemical risk factor for breast cancer based on gene expression profiles. [PDF]

Sci Rep
Achebouche R, Taboureau O.
europepmc   +1 more source

A Critical Analysis of the Impact of Etoposide as a Topoisomerase II Inhibitor in Cervical Cancer Treatment: A Review

Cancer Medicine, Volume 15, Issue 3, March 2026.
Etoposide mediated topoisomerase II inhibition in Cervical Cancer. ABSTRACT Background Etoposide is a semisynthetic derivative of podophyllotoxin and an FDA‐approved topoisomerase II inhibitor that induces DNA strand breaks leading to cancer cell death.
Nikitha Kotian, Yashaswini Reddy, Padmini Pai, Babitha Kampa Sundara   +3 more
wiley   +1 more source

The Downregulation of the Liver Lipid Metabolism Induced by Hypothyroidism in Male Mice: Metabolic Flexibility Favors Compensatory Mechanisms in White Adipose Tissue. [PDF]

Int J Mol Sci
Chamas L, Seugnet I, Tanvé O, Enderlin V, Clerget-Froidevaux MS.   +4 more
europepmc   +1 more source

Targeting Autophagy in Ovarian Cancer: The Emerging Role of Ginsenosides

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background Ovarian cancer, the third most prevalent gynecological malignancy, is frequently diagnosed at an advanced stage owing to its asymptomatic early progression. Despite the application of conventional therapies, clinical management remains limited by adverse effects and the development of drug resistance.
Yuxin Guo, Cuilan Yun, Yuemei Zhang, Xu Yang, Huiqin Liu   +4 more
wiley   +1 more source

Bcor loss promotes Richter transformation of chronic lymphocytic leukemia associated with Notch1 activation in mice. [PDF]

Leukemia
Rompietti C, Adamo FM, Sorcini D, De Falco F, Stella A, Martino G, Bigerna B, Dorillo E, Silva Barcelos EC, Esposito A, Geraci C, Arcaleni R, Bordini J, Scarfò L, Rosati E, Ghia P, Falini B, Sportoletti P.   +17 more
europepmc   +1 more source

Vitex Simplicifolia Abates Cadmium‐Induced Cardiotoxicity Through Antioxidant Activity and Keap1 Targeting

Chemistry &Biodiversity, Volume 23, Issue 3, March 2026.
ABSTRACT This study evaluated the cardioprotective potential of Vitex simplicifolia methanol extract (VSME) and explored its underlying mechanisms of action. Twenty‐five male rats were assigned to five groups (n = 5). Group 1 served as the normal control, while groups 2–5 were exposed to 5 mg/kg body weight of cadmium chloride (CdCl2) daily.
Ifeoma F. Chukwuma, Okechukwu Ignatius Eze, Ogechukwu Colet Okeke, Victor O. Apeh, Timothy Prince Chidike Ezeorba, Chima Okafor   +5 more
wiley   +1 more source

Fibroblast growth factor 23 as a risk factor for incident diabetes. [PDF]

Curr Opin Nephrol Hypertens
de Borst MH.
europepmc   +1 more source

Ferroptosis‐Driven Neuronal Damage Exacerbation in Diabetic Stroke: Implications of SLC7A11 Inhibition

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
The current study uncovered aggravated cerebral ischemic injury and neurological dysfunction following diabetic stroke, in which ferroptosis was involved. SLC7A11 expression was inhibited in the early stages of reperfusion during diabetic stroke, and both ferroptosis inhibitors and neuron‐specific enforced expression of SLC7A11 mitigated neuronal lipid
Siyuan Liu, Min Liu, Binbin Wang, Miao Sun, Huikai Yang, Mengyao Qu, Libin Ma, Likai Shi, Yuxiang Song, Peng Li, Lulu Zhou, Wugang Hou, Weidong Mi, Yulong Ma   +13 more
wiley   +1 more source

Transcriptomic analysis reinforces the implication of spatacsin in neuroinflammation and neurodevelopment. [PDF]

Sci Rep
Toupenet Marchesi L, Stockholm D, Esteves T, Leblanc M, Auger N, Branchu J, El Hachimi KH, Stevanin G.   +7 more
europepmc   +1 more source