Results 171 to 180 of about 1,774 (249)

Move beyond free radical theory of aging

iMetaOmics, Volume 3, Issue 1, March 2026.
Free radicals play a dual, dose‐dependent role in aging. Low levels activate the key sensor adenosine 5'‐monophosphate‐activated protein kinase (AMPK), promoting cell survival mechanisms like autophagy and enhancing mitochondrial health. High levels, however, push AMPK to initiate cell death pathways, such as apoptosis. This positions AMPK as a central
Xiaofeng Dai, Meilan Hu, Ruohan Lyu
wiley   +1 more source

Improving Photosynthetic Efficiency and Biochemical Adaptations in Tomatoes under Drought Stress through Seaweed Aqueous Extract Application. [PDF]

ACS Omega
Munaro D, Nunes A, Kraufenberg L, Touguinha L, Pauletti GF, Schwambach J, Maraschin M, Moura S.   +7 more
europepmc   +1 more source

The Crohn's Disease Exclusion Diet Across the Lifespan, Indications and the Globe: An Expert Review Towards Personalized Therapy in Crohn's Disease

JCC Plus, Volume 1, Issue 2, March 2026.
ABSTRACT Background and Aims The Crohn's disease (CD) exclusion diet (CDED) is an established treatment for active CD with a growing body of evidence supporting its use across diverse populations and disease phenotypes. Particularly effective in mild‐to‐moderate cases, CDED is recognized by clinical guidelines including ESPEN, AGA and ECCO nutritional ...
Rotem Sigall Boneh, Elena Banci, Luca Scarallo, Marta Herrador‐López, Emma P. Halmos, Dror S. Shouval, Nicolette Wierdsma, Chen Sarbagili‐Shabat, Víctor Manuel Navas‐López, Javier Martín‐de‐Carpi, Yulia Ron, Lindsey Albenberg, Henit Yanai, Franck Carbonnel, Johan Van Limbergen, Nitsan Maharshak, Paolo Lionetti, Eytan Wine   +17 more
wiley   +1 more source

Deregulated Homocysteine Metabolism in Friedreich’s Ataxia Patients: A Risk Factor?

Acta Scientific Neurology, 2020
Deepti Pathak, Achal K Srivastava, Sheffali Gulati, Moganty R Rajeswari   +3 more
openaire   +1 more source

Downregulating Platelet Endothelial Cell Adhesion Molecule‐1 Enhances Learning and Memory and Alleviates Hallmark Pathologies in Alzheimer's Disease

MedComm, Volume 7, Issue 3, March 2026.
CD31 upregulation in 5xFAD mice activates STAT1/Irf1 signaling, driving abnormal gene transcription, Aβ and tau accumulation, microglial activation, and neuroinflammation, leading to cognitive decline. Systemic CD31 knockdown suppresses STAT1/Irf1 activity, restores gene expression balance, reduces Aβ and tau pathologies, alleviates neuroinflammation ...
Qiuzhi Zhou, Fei Sun, Yao Zhang, Xiaojian Cao, Mengzhu Li, Haitao Yu, Tao Jiang, Shihong Li, Weixia Wang, Jiazhao Xie, Ting He, Yanchao Liu, Xiuping Liu, Ying Yang, Dan Ke, Xiao‐Chuan Wang, Enjie Liu, Jian‐Zhi Wang   +17 more
wiley   +1 more source

<i>In vitro</i> microbiota model recapitulates and predicts individualised sensitivity to dietary emulsifier. [PDF]

Gut
Rytter H, Naimi S, Wu G, Lewis J, Duquesnoy M, Vigué L, Tenaillon O, Belda E, Vazquez-Gomez M, Touly N, Arnone D, Hao F, Ley RE, Clément K, Peyrin-Biroulet L, Patterson AD, Gewirtz AT, Chassaing B.   +17 more
europepmc   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, Volume 46, Issue 2, Page 352-381, March 2026.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Antioxidant activity and protective effect of phyto-active compounds of Crataegus azarolus berries decoction extract against acetic acid-induced hepatorenal injuries in male rats. [PDF]

Physiol Rep
Sammari H, Abidi A, Jedidi S, Dhawefi N, Sebai H.   +4 more
europepmc   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Sex-specific benefits of a combined supplementation of B vitamins, nicotinamide riboside, folate and cobalamin, in a murine model of heart failure. [PDF]

Biol Sex Differ
Boitard SE, Delouche M, Karoui A, Gressette M, Momken I, Bouchard B, Mercier-Nomé F, Imbard A, Lemaire C, Garnier A, Ruiz M, Mericskay M, Piquereau J.   +12 more
europepmc   +1 more source