Results 181 to 190 of about 1,774 (249)

Multifacet Roles of Cellular Senescence in Cancer: Mechanisms and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Cellular senescence shapes tumor progression through both antitumor and protumor mechanisms. Senescence triggered by telomere shortening restricts malignant transformation and limits tumor cell proliferation, while the senescence‐associated secretory phenotype (SASP) secretion enhances antitumor immunity by activating cytotoxic T cells.
Huajie Mao, Wanning Liu, Yuanyuan Su, Yuxuan Ma, Xiaodi Zhao, Yuanyuan Lu   +5 more
wiley   +1 more source

Alterations in Cardiac Metabolism by <i>Trypanosoma cruzi</i> Infection: A Metabolomic Assessment by RPLC-MS and GC-MS. [PDF]

ACS Infect Dis
de Sá HC, Cardim Barreto B, Gomes das Neves MV, Santos MGS, Cardoso CMA, Fraga Vasconcelos J, Pereira Soares MB, André Baptista Canuto G.   +7 more
europepmc   +1 more source

The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance

MedComm – Oncology, Volume 5, Issue 1, March 2026.
One‐Carbon metabolism in T‐cell activation and tumor competition. T‐cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One‐carbon metabolism plays a crucial role in histone and DNA methylation in activated T cells.
Yuting Jiang, Guoliang Zhou, Qian Zhang, Shengtao Zhou   +3 more
wiley   +1 more source

The JAK/STAT Pathway in Cancer: From Molecular Mechanisms to Clinical Applications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Dysregulated JAK/STAT signaling and related genetic mutations are strongly associated with cancer progression, including promoting tumor proliferation, suppressing apoptosis, inducing immune suppression, participating in drug resistance. Based on the function of the JAK/STAT pathway in disease pathogenesis, numerous agents targeting the JAK/STAT ...
Yixing Liao, Qi Wei, Hongjun Song, Hao Zeng, Chang Qi, Yunchang Meng, Yuanyuan Zhang, Yuanyuan Zhang, Weimin Li, Yalun Li, Panwen Tian   +10 more
wiley   +1 more source

Metabolic Transcriptional Activation in Ulcerative Colitis Identified Through scRNA-seq Analysis. [PDF]

Genes (Basel)
Desterke C, Fu Y, Francés R, Mata-Garrido J.   +3 more
europepmc   +1 more source

Thermo‐Chemically Modified Silk Scaffolds Reveal Niche‐Driven Regulation of Hematopoiesis and Fibrosis

Small, Volume 22, Issue 18, 25 March 2026.
We introduce a versatile 3D platform that recreates key physical and biological features of the human bone marrow. By integrating tunable silk biomaterials, stromal cells, and human hematopoietic progenitors, the model captures both healthy and diseased microenvironments, analysis of blood formation, and its disruption in pathological conditions ...
Christian A. Di Buduo, Carolina P. Miguel, Giulia Della Rosa, Vittorio Abbonante, Santo Diprima, Delfina Tosi, Marta Filibian, Daniele Cattaneo, Jugal Kishore Sahoo, Nicola Tirelli, Alessandra Iurlo, Umberto Gianelli, David L. Kaplan, Alessandra Balduini   +13 more
wiley   +1 more source

Diabetic neuropathy: A NRF2 disease? [PDF]

J Diabetes
Neagu M, Constantin C, Surcel M, Munteanu A, Scheau C, Savulescu-Fiedler I, Caruntu C.   +6 more
europepmc   +1 more source

Remodeling the Inflammatory Microenvironment: Nanomaterial‐Based Targeted Strategies for Systemic Lupus Erythematosus and Lupus Nephritis

Small Science, Volume 6, Issue 3, March 2026.
Current treatments for severe lupus nephritis are limited by side effects due to poor drug targeting. This review explores how smart nanomaterials—like liposomes and biomimetic carriers—can precisely deliver drugs to overactive immune cells and the kidneys. These nanotherapeutics enhance efficacy, reduce toxicity, and enable combination strategies. The
Cheng Zhou, Jiayi Li, Jian Zhang, Haifeng Wang, Haitao Lu, Shunlai Shang, Wenge Li   +6 more
wiley   +1 more source

Leaf transcriptome differences between diploid and tetraploid bahiagrass

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Polyploid individuals of the subtropical forage grass Paspalum notatum Flüggé (bahiagrass) exhibit distinct phenotypes, including apomixis, enhanced vigor, gigas effects, and increased stress tolerance. While apomixis‐based breeding programs supported by molecular tools have improved agronomic traits such as growth habit, forage dry matter ...
Maricel Podio, Danilo Fabrizio Santoro, Carolina Marta Colono, Juan Pablo A. Ortiz, Emidio Albertini, Silvina Claudia Pessino   +5 more
wiley   +1 more source

Comparative brain metabolomics reveals shared and distinct metabolic alterations in Alzheimer's disease and progressive supranuclear palsy. [PDF]

Alzheimers Dement
Batra R, Krumsiek J, Wang X, Allen M, Blach C, Kastenmüller G, Arnold M, Ertekin-Taner N, Kaddurah-Daouk R, Alzheimer's Disease Metabolomics Consortium (ADMC).   +9 more
europepmc   +1 more source