Results 41 to 50 of about 1,774 (249)
Gut MicrobesMetabolic syndrome is, in humans, associated with alterations in the composition and localization of the intestinal microbiota, including encroachment of bacteria within the colon’s inner mucus layer.
Melissa C. Kordahi +3 more
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Microbiology Spectrum, 2022 Evidence is accumulating that plant viruses alter host plant traits in ways that modify their insect vectors’ behavior. These alterations often enhance virus transmission, which has led to the hypothesis that these effects are manipulations caused by ...
Quentin Chesnais +6 more
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Triptolide Administration Alters Immune Responses to Mitigate Insulin Resistance in Obese States
BiomoleculesIndividuals who are overweight or obese are at increased risk of developing prediabetes and type 2 diabetes, yet the direct molecular mechanisms that connect diabetes to obesity are not clear.
Lyudmila Grodsky +3 more
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BMC Genomics, 2023 Background In breast cancer, as in all cancers, genetic and epigenetic deregulations can result in out-of-context expressions of a set of normally silent tissue-specific genes.
Emmanuelle Jacquet +7 more
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Hepatic STAMP2 decreases hepatitis B virus X protein-associated metabolic deregulation [PDF]
Experimental & Molecular Medicine, 2012 Six transmembrane protein of prostate 2 (STAMP2) plays a key role in linking inflammatory and diet-derived signals to systemic metabolism. STAMP2 is induced by nutrients/feeding as well as by cytokines such as TNFα, IL-1β, and IL-6. Here, we demonstrated that STAMP2 protein physically interacts with and decreases the stability of hepatitis B virus X ...
Kim, HY Kim, Hye Young +3 more
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Cancer Cell International, 2021 Type 2 diabetes mellitus and breast cancer are complex, chronic, heterogeneous, and multi-factorial diseases; with common risk factors including but not limited to diet, obesity, and age. They also share mutually inclusive phenotypic features such as the
Ilhaam Ayaz Durrani +2 more
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Hypermutation of DPYD Deregulates Pyrimidine Metabolism and Promotes Malignant Progression [PDF]
Molecular Cancer Research, 2016 Abstract New strategies are needed to diagnose and target human melanoma. To this end, genomic analyses was performed to assess somatic mutations and gene expression signatures using a large cohort of human skin cutaneous melanoma (SKCM) patients from The Cancer Genome Atlas (TCGA) project to identify critical differences between ...
Lauren, Edwards +2 more
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Frontiers in Oncology, 2020 Bone metastasis is the leading cause of prostate cancer (PCa) mortality, frequently marking the progression to castration-resistant PCa. Dysregulation of the androgen receptor pathway is a common feature of castration-resistant PCa, frequently appearing ...
Federico La Manna +14 more
doaj +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Metabolic Deregulation of the Blood-Outer Retinal Barrier in Retinitis Pigmentosa [PDF]
Cell Reports, 2019 Retinitis pigmentosa (RP) initiates with diminished rod photoreceptor function, causing peripheral and night-time vision loss. However, subsequent loss of cone function and high-resolution daylight and color vision is most debilitating. Visual pigment-rich photoreceptor outer segments (OS) undergo phagocytosis by the retinal pigment epithelium (RPE ...
Wei Wang +19 more
openaire +3 more sources