Results 91 to 100 of about 3,807,237 (401)

Improving fatty acids production by engineering dynamic pathway regulation and metabolic control [PDF]

, 2014
Global energy demand and environmental concerns have stimulated increasing efforts to produce carbon-neutral fuels directly from renewable resources.
Koffas, Mattheos, Li, Lingyun, Stephanopoulos, Gregory, Xu, Peng, Zhang, Fuming   +4 more
core   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Advanced Strategies for Production of Natural Products in Yeast

iScience, 2020
Natural products account for more than 50% of all small-molecule pharmaceutical agents currently in clinical use. However, low availability often becomes problematic when a bioactive natural product is promising to become a pharmaceutical or leading ...
Ruibing Chen, Shan Yang, Lei Zhang, Yongjin J. Zhou   +3 more
doaj  

The application of microfluidic-based technologies in the cycle of metabolic engineering

Synthetic and Systems Biotechnology, 2016
The process of metabolic engineering consists of multiple cycles of design, build, test and learn, which is typically laborious and time-consuming. To increase the efficiency and the rate of success of strain engineering, novel instrumentation must be ...
Xiaoyan Ma, Yi-Xin Huo
doaj   +1 more source

Analytic and Numerical Models of Oxygen and Nutrient Diffusion, Metabolism Dynamics, and Architecture Optimization in Three-Dimensional Tissue Constructs with Applications and Insights in Cerebral Organoids [PDF]

, 2015
Diffusion models are important in tissue engineering as they enable an understanding of molecular delivery to cells in tissue constructs. As three-dimensional (3D) tissue constructs become larger, more intricate, and more clinically applicable, it will be essential to understand internal dynamics and signaling molecule concentrations throughout the ...
arxiv   +1 more source

Complex systems in metabolic engineering [PDF]

Current Opinion in Biotechnology, 2015
Metabolic engineers manipulate intricate biological networks to build efficient biological machines. The inherent complexity of this task, derived from the extensive and often unknown interconnectivity between and within these networks, often prevents researchers from achieving desired performance.
Andrea L. Halweg-Edwards, James D. Winkler, Ryan T. Gill, Alaksh Choudhury, Keesha E. Erickson   +4 more
openaire   +3 more sources

Grounding knowledge and normative valuation in agent-based action and scientific commitment [PDF]

, 2018
Philosophical investigation in synthetic biology has focused on the knowledge-seeking questions pursued, the kind of engineering techniques used, and on the ethical impact of the products produced.
A Clark, A Clark, A Clark, A Minelli, A Pickering, B Calcott, B Goodwin, C Kendig, C Kendig, C Kendig, C Swanton, D Dellomonaco, D Endy, D Erwin, D Gibson, D Sprinzak, EF Keller, EJ Lowe, G Wagner, H Chang, H Chang, H Chang, H Chang, H Longino, H-J Rheinberger, I Hacking, I Hacking, J Dupré, J Dupré, J Hornsby, J Rouse, J Rouse, Latour, B./Johnson, J, M Grene, M Grene, M Kirschner, M Morange, M Morange, M O’Malley, M O’Malley, M Polanyi, M West-Eberhard, M West-Eberhard, P Mullins, P Schyfter, R Brent, R Georgianna, R Wilson, TT Eckdahl, VJ Martin, Weihua Wang   +50 more
core   +1 more source

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

Molecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi, Janelle‐Cheri Millen, Romela Irene Ramos, Jennifer A. Linehan, Timothy G. Wilson, Dave S. B. Hoon, Matias A. Bustos   +6 more
wiley   +1 more source

The path to next generation biofuels: successes and challenges in the era of synthetic biology

Microbial Cell Factories, 2010
Volatility of oil prices along with major concerns about climate change, oil supply security and depleting reserves have sparked renewed interest in the production of fuels from renewable resources.
Gonzalez Ramon, Fava Fabio, Dellomonaco Clementina   +2 more
doaj   +1 more source

In silico gene knockout prediction using a hybrid of Bat algorithm and minimization of metabolic adjustment

Journal of Integrative Bioinformatics, 2021
Microorganisms commonly produce many high-demand industrial products like fuels, food, vitamins, and other chemicals. Microbial strains are the strains of microorganisms, which can be optimized to improve their technological properties through metabolic ...
Man Mei Yen, Mohamad Mohd Saberi, Choon Yee Wen, Ismail Mohd Arfian   +3 more
doaj   +1 more source