Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Metabolic engineering of Saccharomyces cerevisiae for neoxanthin production. [PDF]
Arenas N, Cataldo VF, Agosin E.
europepmc +1 more source
Metabolic engineering @ Inbio.be : platform tools and technologies for the production of complex metabolites [PDF]
De Maeseneire, Sofie +2 more
core
The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley +1 more source
Metabolic engineering of Streptomyces explomaris for increased production of the reverse antibiotic nybomycin. [PDF]
Shu W +8 more
europepmc +1 more source
SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas +18 more
wiley +1 more source
Metabolic engineering and late-stage functionalization expand the chemical space of the antimalarial premarineosin A. [PDF]
McBride CM +16 more
europepmc +1 more source
Metabolic engineering strategies for microbial synthesis of oleochemicals
Brian F. Pfleger +2 more
openalex +2 more sources
ABSTRACT Background Neurodegeneration with brain iron accumulation (NBIA) comprises a genetically and clinically heterogeneous group of rare neurological disorders characterized particularly by iron accumulation in the basal ganglia. To date, 15 genes have been associated with NBIA.
Seda Susgun +95 more
wiley +1 more source

