Tunable Thermoshrinkable Hydrogels for 4D Fabrication of Cell‐Seeded Channels
A thermoresponsive polymer with methacrylate groups for photo‐cross‐linking, based on polyethylene glycol, N‐isopropylacrylamide, and 2‐hydroxyethyl acrylate is synthetized to yield hydrogels that shrink upon temperature increase. The new polymer enables the fabrication of cell‐laden perfusable channels with diameters below 200 µm by combining ...
Greta Di Marco+12 more
wiley +1 more source
Editorial: Microbial co-cultures: a new era of synthetic biology and metabolic engineering, volume II. [PDF]
Jaiswal DK+4 more
europepmc +1 more source
Transient Stiffness Patterning in Hydrogels Driven by Dissipative Mechanochemical Coupling
Force‐induced disulfide bond rupture in a polymer‐based hydrogel, coupled with chemical or electrochemical reoxidation, leads to the transient modulation of the hydrogel's stiffness properties. High spatiotemporal control is achieved by this dissipative process, enabling the development of out‐of‐equilibrium stiffness patterns and transient, dose ...
Roberto Baretta+2 more
wiley +1 more source
Metabolic engineering of narrow-leafed lupin for the production of enantiomerically pure (-)-sparteine. [PDF]
Mancinotti D, Yang T, Geu-Flores F.
europepmc +1 more source
Matrix Tropism Influences Endometriotic Cell Attachment Patterns
The influence of substrate stiffness and multicellular coculture on endometriotic cell attachment to extracellular matrix‐laden microarrayed islands is reported. This model investigates early endometriotic cell attachment, aiming to capture “lesion initiation events”.
Hannah S. Theriault+7 more
wiley +1 more source
Metabolic engineering of Yarrowia lipolytica for the production and secretion of the saffron ingredient crocetin. [PDF]
Zhou T+5 more
europepmc +1 more source
A biomimetic nanomedicine (RBLN) constructed by loading natural antioxidants to clinically used layered double hydroxide nanoparticles is surface coated with fresh or senescent red blood cell membrane for balanced drug delivery to hepatocytes and KCs, thereby simultaneously alleviating liver oxidant stress and inflammation for effective drug‐induced ...
Jiahui Shao+8 more
wiley +1 more source
Melanin in fungi: advances in structure, biosynthesis, regulation, and metabolic engineering. [PDF]
Qin Y, Xia Y.
europepmc +1 more source
Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery
This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer+10 more
wiley +1 more source