Results 71 to 80 of about 623,308 (344)

Metabolic engineering with systems biology tools to optimize production of prokaryotic secondary metabolites [PDF]

, 2016
This Highlight examines current status of metabolic engineering and systems biology tools deployed for the optimal production of prokaryotic secondary metabolites.
Charusanti, Pep, Kim, Hyun Uk, Lee, Sang Yup, Weber, Tilmann   +3 more
core   +2 more sources

Metabolic engineering of Bacillus subtilis with an Endopolygalacturonase gene Isolated from Pectobacterium. carotovorum ; a Plant Pathogenic Bacterial Strain [PDF]

, 2021
Nagina Rafique, Saiqa Bashir, Muhammad Zubair Khan, Imran Hayat, Willium-Orts, Dominic W. S. Wong   +5 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Automation on the generation of genome scale metabolic models [PDF]

, 2012
Background: Nowadays, the reconstruction of genome scale metabolic models is a non-automatized and interactive process based on decision taking. This lengthy process usually requires a full year of one person's work in order to satisfactory collect ...
de Córdoba, P. Fernández, Fuente, D., Gamermann, D., Montagud, A., Reyes, R., Triana, J., Urchuegía, J. F.   +6 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

The application of microfluidic-based technologies in the cycle of metabolic engineering

Synthetic and Systems Biotechnology, 2016
The process of metabolic engineering consists of multiple cycles of design, build, test and learn, which is typically laborious and time-consuming. To increase the efficiency and the rate of success of strain engineering, novel instrumentation must be ...
Xiaoyan Ma, Yi-Xin Huo
doaj   +1 more source

Transcription Factor Engineering for High-Throughput Strain Evolution and Organic Acid Bioproduction: A Review

Frontiers in Bioengineering and Biotechnology, 2020
Metabolic regulation of gene expression for the microbial production of fine chemicals, such as organic acids, is an important research topic in post-genomic metabolic engineering.
Jia-Wei Li, Xiao-Yan Zhang, Hui Wu, Yun-Peng Bai   +3 more
doaj   +1 more source

In silico gene knockout prediction using a hybrid of Bat algorithm and minimization of metabolic adjustment

Journal of Integrative Bioinformatics, 2021
Microorganisms commonly produce many high-demand industrial products like fuels, food, vitamins, and other chemicals. Microbial strains are the strains of microorganisms, which can be optimized to improve their technological properties through metabolic ...
Man Mei Yen, Mohamad Mohd Saberi, Choon Yee Wen, Ismail Mohd Arfian   +3 more
doaj   +1 more source

The future of bioethanol [PDF]

, 2019
Yeasts have been domesticated by mankind before horses. After the mastering of alcoholic fermentation for centuries, yeasts have become the protagonist of one of the most important biotechnological industries worldwide: the production of bioethanol. This
Basso, Luiz C., Basso, Thiago O., Walker, Graeme M., Walker, Roy S.K.   +3 more
core  

Genome scale engineering techniques for metabolic engineering [PDF]

Metabolic Engineering, 2015
Metabolic engineering has expanded from a focus on designs requiring a small number of genetic modifications to increasingly complex designs driven by advances in genome-scale engineering technologies. Metabolic engineering has been generally defined by the use of iterative cycles of rational genome modifications, strain analysis and characterization ...
Liu, Rongming, Bassalo, Marcelo C., Zeitoun, Ramsey I., Gill, Ryan T.   +3 more
openaire   +2 more sources