Results 81 to 90 of about 1,689,302 (242)

Male mouse skeletal muscle lacking HuR shows enhanced glucose disposal at a young age

Frontiers in Physiology
IntroductionMetabolic flexibility is the ability of a system to switch between metabolic substrates. Human and murine skeletal muscle tissues and cells with decreased activity of the regulatory RNA-binding protein, human antigen R (HuR), have decreased ...
Robert C. Noland, Robert C. Noland, Sujoy Ghosh, Sujoy Ghosh, Carlos J. Crisanto, Antonio Aleman, McKenna K. Chaney, Maitri K. Chauhan, Layla G. Loftis, Ally C. Goad, Christin F. Rickman, Samuel E. Velasquez, Jaycob D. Warfel, Jaycob D. Warfel   +13 more
doaj   +1 more source

Immunometabolic Links between Estrogen, Adipose Tissue and Female Reproductive Metabolism

Biology, 2019
The current knowledge of sex-dependent differences in adipose tissue biology remains in its infancy and is motivated in part by the desire to understand why menopause is linked to an increased risk of metabolic disease.
Sally A. Eaton, Jaswinder K. Sethi
doaj   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

Utility of the APE2 Score as a Diagnostic Tool for Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To retrospectively evaluate the diagnostic performance of the Antibody Prevalence in Epilepsy and Encephalopathy (APE2) score relative to clinician‐adjudicated autoimmune encephalitis (AE) and the Graus criteria in a tertiary neuroimmunology referral cohort, including antibody‐negative AE.
Bijoya Basu, Sophia F. Damman, Samhitha M. Rai, Hesham Abboud   +3 more
wiley   +1 more source

Metabolic and Neuroendocrine Responses to Intermittent Fasting in Obesity

Medicina
Background and Objectives: Intermittent fasting (IF) has emerged as a nutritional strategy capable of modulating circadian alignment, metabolic efficiency, and neuroendocrine regulation in individuals with obesity.
Salvatore Allocca, Antonietta Monda, Maria Casillo, Fiorenzo Moscatelli, Marco La Marra, Vincenzo Monda, Girolamo Di Maio, Raffaele Ivan Cincione, Paride Vasco, Marcellino Monda, Rita Polito, Giovanni Messina, Antonietta Messina   +12 more
doaj   +1 more source

Whole-Body Metabolic Flexibility is Discordant with Skeletal Muscle Metabolism [PDF]

Metabolic disease continues to be a worldwide problem that affects all ages, sexes, and socioeconomic statuses. The development of metabolic disease is multifactorial with both genetic and environmental components.
Krassovskaia, Polina
core   +1 more source

Added Value to GLP-1 Receptor Agonist: Intermittent Fasting and Lifestyle Modification to Improve Therapeutic Effects and Outcomes

Biomedicines
Obesity remains a major global health challenge, with glucagon-like peptide-1 receptor agonists (GLP-1RAs) providing substantial yet sensitive benefits in weight reduction, glycemic control, and cardiovascular protection.
Dragos Cozma, Cristina Văcărescu, Claudiu Stoicescu   +2 more
doaj   +1 more source

A Novel KCNA1 Variant in a Patient With Tremor and Autism Spectrum Disorder Causes Mixed LOF/GOF Defects of Kv1.1 Channels

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Variants in KCNA1, encoding the Kv1.1 potassium channel, cause neurological disorders including episodic ataxia and developmental and epileptic encephalopathy. We identified a novel KCNA1 variant (A401T) in a 16‐year‐old patient with autism spectrum disorder, borderline intellectual disability, and tremor, without episodic ataxia or epilepsy ...
Juan Darío Ortigoza‐Escobar, Laura Marti‐Sánchez, Loreto Martorell, Giorgia Dinoi, Antonio Vittorio Buono, Annamaria De Luca, Antonella Liantonio, Paola Imbrici   +7 more
wiley   +1 more source

Functional Impact of Alternative Metabolic Substrates in Failing Human Cardiomyocytes

JACC: Basic to Translational Science
Summary: Recent studies suggest that metabolic dysregulation in patients with heart failure might contribute to myocardial contractile dysfunction. To understand the correlation between function and energy metabolism, we studied the impact of different ...
Alexia Vite, PhD, Timothy R. Matsuura, PhD, Kenneth C. Bedi, BS, Emily L. Flam, PhD, Zoltan Arany, MD, PhD, Daniel P. Kelly, MD, Kenneth B. Margulies, MD   +6 more
doaj   +1 more source

Real‐World Longitudinal Data on the Impact of Hydroxychloroquine Blood Level Monitoring on Lupus Outcomes: Results of a Prospective Longitudinal Cohort Study

Arthritis Care &Research, EarlyView.
Objective Hydroxychloroquine (HCQ) is a cornerstone therapy in systemic lupus erythematosus (SLE), but the weight‐based dosing does not account for clinical factors that can introduce individual variability in drug metabolism and clearance. We leveraged longitudinal data from a prospective SLE cohort to identify clinical factors that predict ...
Jay J. Patel, Fauzia Hollangel, Caroline Packee, Amita Kapoor, Brad Rovin, Nathalie Costedoat‐Chalumeau, Shivani Garg   +6 more
wiley   +1 more source