Results 61 to 70 of about 116,098 (154)

Insulin Receptor Isoform A Modulates Metabolic Reprogramming of Breast Cancer Cells in Response to IGF2 and Insulin Stimulation

Cells, 2019
Previously published work has demonstrated that overexpression of the insulin receptor isoform A (IR-A) might play a role in cancer progression and metastasis.
Veronica Vella, Maria Luisa Nicolosi, Marika Giuliano, Andrea Morrione, Roberta Malaguarnera, Antonino Belfiore   +5 more
doaj   +1 more source

Added Value to GLP-1 Receptor Agonist: Intermittent Fasting and Lifestyle Modification to Improve Therapeutic Effects and Outcomes

Biomedicines
Obesity remains a major global health challenge, with glucagon-like peptide-1 receptor agonists (GLP-1RAs) providing substantial yet sensitive benefits in weight reduction, glycemic control, and cardiovascular protection.
Dragos Cozma, Cristina Văcărescu, Claudiu Stoicescu   +2 more
doaj   +1 more source

Functional Impact of Alternative Metabolic Substrates in Failing Human Cardiomyocytes

JACC: Basic to Translational Science
Summary: Recent studies suggest that metabolic dysregulation in patients with heart failure might contribute to myocardial contractile dysfunction. To understand the correlation between function and energy metabolism, we studied the impact of different ...
Alexia Vite, PhD, Timothy R. Matsuura, PhD, Kenneth C. Bedi, BS, Emily L. Flam, PhD, Zoltan Arany, MD, PhD, Daniel P. Kelly, MD, Kenneth B. Margulies, MD   +6 more
doaj   +1 more source

Metabolic fuel selection: the importance of being flexible [PDF]

Journal of Clinical Investigation, 2004
Studies in genetically engineered mice have shown the importance of cross-talk between organs in the regulation of energy metabolism. In this issue, a careful metabolic characterization of mice with genetic deficiency of the GLUT4 glucose transporter in adipocytes and muscle is reported.
openaire   +2 more sources

A flexible view of metabolic network [PDF]

BMC Systems Biology, 2007
Ko-Yun Lo, Andrew R. Dalby
openaire   +1 more source

Intake of palmitic acid and its association with metabolic flexibility in middle-aged individuals: a preliminary study

Redox Experimental Medicine
Objective: This study aimed to assess the relationship between dietary palmitic acid (PA) intake and its association with body fat deposition and metabolic flexibility (MF) in middle-aged healthy individuals.
Elisabetta Murru, Gianfranca Carta, Claudia Manca, Alessia Leone, Chiara Murru, Michele Ruggiu, Roberto Solinas, Roberta Montisci, Filippo Tocco, Sebastiano Banni   +9 more
doaj   +1 more source

Maximal fat oxidation assessment in active postmenopausal females: A novel relative power FATmax test

Physiological Reports
This study compared a novel relative‐to‐body‐mass FATmax test (RFT; 0.15 W/kg/4 min from 0.45 W/kg) with a traditional absolute power FATmax test (AFT; 10 W/3min15sec from 30 W) in postmenopausal females. The aim was to determine whether the RFT protocol
Jordi Monferrer‐Marín, Ainoa Roldán, Jørn Wulff Helge, Cristina Blasco‐Lafarga   +3 more
doaj   +1 more source

A Comparative Transcriptomic Study Reveals Temporal and Genotype-Specific Defense Responses to Botrytis cinerea in Grapevine

Journal of Fungi
Grapevine (Vitis vinifera L.), a globally significant crop, is highly susceptible to Botrytis cinerea, the causative agent of gray mold disease. This study investigates transcriptomic responses to B.
Flavia Angela Maria Maggiolini, Annalisa Prencipe, Carlo Bergamini, Antonio Domenico Marsico, Marco Vendemia, Marika Santamaria, Maria Angela Giannandrea, Margherita D’Amico, Lucia Rosaria Forleo, Rocco Perniola, Riccardo Velasco, Maria Francesca Cardone   +11 more
doaj   +1 more source

Metabolic Flexibility in Cancer Cells

, 2022
Abstract Colorectal cancer is the third most occurring cancer type among both men and women in the United States. Even though cancer therapies have been revolutionarily improved over the decades, there is a high demand for more effective treatments, making research within the complex aspect of cancer crucial for the design of highly specific and ...
Haave, Eilin, Halvorsen, Camilla
openaire   +1 more source

Are Individuals With Type 2 Diabetes Metabolically Inflexible? A Systematic Review and Meta‐Analysis

Endocrinology, Diabetes & Metabolism
Aim Type 2 diabetes (T2D) is characterised by insulin resistance and possibly by impaired metabolic flexibility, the latter referring to the body's ability to switch between fuel sources.
Maria Hansen, Kristine Kjær Lange, Martin Bjørn Stausholm, Flemming Dela   +3 more
doaj   +1 more source