Results 41 to 50 of about 1,689,302 (242)

The effect of 12 weeks of combined training on hepatic fat content and metabolic flexibility of individuals with non-alcoholic fatty liver disease: Protocol of an open-label, single-center randomized control trial

Frontiers in Nutrition, 2023
IntroductionMetabolic flexibility (MetF) is the capacity of an organism to oxidate substrate according to substrate availability or demand. The mismatch of substrate availability and oxidation may cause ectopic fat accumulation in the muscle and the ...
Wei Huang, Wei Huang, Weiqi Ruan, Weiqi Ruan, Cuilan Huo, Yanyu Lin, Yanyu Lin, Tian Wang, Tian Wang, Xiangdi Dai, Xiangdi Dai, Haonan Zhai, Jiasheng Ma, Jingyi Zhang, Jingyi Zhang, Jin Lu, Jie Zhuang, Jie Zhuang   +17 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Development of the MetFlex Index™: associations between cardiometabolic risk factors and fitness using a novel approach with blood lactate

Frontiers in Physiology
IntroductionCardiometabolic health is declining in the U.S. and anticipated to worsen over the next 30 years. Measurements of cardiometabolic health include blood metabolite profiles. One such metabolite is blood lactate.
Bryan Jasker, Bryan Jasker, Daniel Dodd, Clara B. Peek, Clara B. Peek, Garett J. Griffith   +5 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Comparative Morphophysiological Analyses and Molecular Profiling Reveal Pi-Efficient Strategies of a Traditional Rice Genotype

Frontiers in Plant Science, 2016
Phosphate (Pi) deficiency severely affects crop yield. Modern high yielding rice genotypes are sensitive to Pi deficiency whereas traditional rice genotypes are naturally compatible with low Pi ecosystems. However, the underlying molecular mechanisms for
Poonam eMehra, Bipin Kumar Pandey, Jitender eGiri   +2 more
doaj   +1 more source

Cycling for Weight Loss May Clear Carbohydrates Rather Than Fat, Irrespective of Normal or Mildly Reduced Normobaric Oxygen

Obesities, 2022
A single-center randomized, controlled cross-over exercise intervention in 20 women willing to reduce weight (20–40 y, BMI: 27.4 ± 2.1), with the aim to examine potential benefits for weight loss under normal (N-Ox: 20.9%) and mildly reduced (R-Ox: 17.0%)
Victor V. A. M. Schreurs, Tjieu Maas, Joost J. G. C. van den Borne, Jaap Keijer   +3 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Is lean mass quantity or quality the determinant of maximal fat oxidation capacity? The potential mediating role of cardiorespiratory fitness

Journal of the International Society of Sports Nutrition
Background Impaired fat oxidation is linked to cardiometabolic risk. Maximal fat oxidation rate (MFO) reflects metabolic flexibility and is influenced by lean mass, muscle strength, muscle quality – defined as the ratio of strength to mass – and ...
Edgardo Opazo-Díaz, Juan Corral-Pérez, Alejandro Pérez-Bey, Alberto Marín-Galindo, Adrián Montes-de-Oca-García, María Rebollo-Ramos, Daniel Velázquez-Díaz, Cristina Casals, Jesús-Gustavo Ponce-González   +8 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From the Plate to the Nucleus: Dietary Control of Nuclear Receptors in the Development and Prevention of Metabolic Diseases

Receptors
Nutrient-sensing nuclear receptors (NSNRs), including PPARs, FXR, LXRs, RAR/RXR, VDR, and related orphan receptors, integrate a molecular interface that allows diet to communicate directly with the genome.
Ivan Torre-Villalvazo, Claudia Tovar-Palacio, Andrea Díaz-Villaseñor, Berenice Palacios-González   +3 more
doaj   +1 more source