Results 21 to 30 of about 116,098 (154)

A Mathematical Model of the Human Metabolic System and Metabolic Flexibility [PDF]

Bulletin of Mathematical Biology, 2014
In healthy subjects some tissues in the human body display metabolic flexibility, by this we mean the ability for the tissue to switch its fuel source between predominantly carbohydrates in the postprandial state and predominantly fats in the fasted state.
Pearson, Taliesin, Wattis, Jonathan A.D., King, John. R., MacDonald, Ian A., Mazzatti, Dawn   +4 more
openaire   +4 more sources

Simulating Metabolic Flexibility in Low Energy Expenditure Conditions Using Genome-Scale Metabolic Models

Metabolites, 2021
Metabolic flexibility is the ability of an organism to adapt its energy source based on nutrient availability and energy requirements. In humans, this ability has been linked to cardio-metabolic health and healthy aging.
Andrea Cabbia, Peter A. J. Hilbers, Natal A. W. van Riel   +2 more
doaj   +1 more source

The flexibility of Apicomplexa parasites in lipid metabolism

PLOS Pathogens, 2022
Apicomplexa are obligate intracellular parasites responsible for major human infectious diseases such as toxoplasmosis and malaria, which pose social and economic burdens around the world. To survive and propagate, these parasites need to acquire a significant number of essential biomolecules from their hosts. Among these biomolecules, lipids are a key
Serena Shunmugam, Christophe-Sébastien Arnold, Sheena Dass, Nicholas J. Katris, Cyrille Y. Botté   +4 more
openaire   +5 more sources

Decreased Metabolic Flexibility in Skeletal Muscle of Rat Fed with a High-Fat Diet Is Recovered by Individual CLA Isomer Supplementation via Converging Protective Mechanisms

Cells, 2020
Energy balance, mitochondrial dysfunction, obesity, and insulin resistance are disrupted by metabolic inflexibility while therapeutic interventions are associated with improved glucose/lipid metabolism in skeletal muscle. Conjugated linoleic acid mixture
Giovanna Trinchese, Gina Cavaliere, Fabiano Cimmino, Angela Catapano, Gianfranca Carta, Claudio Pirozzi, Elisabetta Murru, Adriano Lama, Rosaria Meli, Paolo Bergamo, Sebastiano Banni, Maria Pina Mollica   +11 more
doaj   +1 more source

Metabolic Flexibility and Inflexibility: Pathology Underlying Metabolism Dysfunction

Journal of Clinical Medicine, 2023
Metabolic flexibility can be defined as the ability of the skeletal muscle to adjust its utilization of substrate pathways [...]
Marni E. Shoemaker, Zachary M. Gillen, David H. Fukuda, Joel T. Cramer   +3 more
openaire   +2 more sources

L-Carnitine and Acylcarnitines: Mitochondrial Biomarkers for Precision Medicine

Metabolites, 2021
Biomarker discovery and implementation are at the forefront of the precision medicine movement. Modern advances in the field of metabolomics afford the opportunity to readily identify new metabolite biomarkers across a wide array of disciplines.
Marc R. McCann, Mery Vet George De la Rosa, Gus R. Rosania, Kathleen A. Stringer   +3 more
doaj   +1 more source

Post-exercise Warm or Cold Water Immersion to Augment the Cardiometabolic Benefits of Exercise Training: A Proof of Concept Trial

Frontiers in Physiology, 2021
We investigated whether substituting the final half within 60-min bouts of exercise with passive warm or cold water immersion would provide similar or greater benefits for cardiometabolic health.
Brooke M. Russell, Brooke M. Russell, Courtney R. Chang, Courtney R. Chang, Terry Hill, James D. Cotter, Monique E. Francois, Monique E. Francois   +7 more
doaj   +1 more source

Mitochondrial Utilization of Competing Fuels Is Altered in Insulin Resistant Skeletal Muscle of Non-obese Rats (Goto-Kakizaki)

Frontiers in Physiology, 2020
AimInsulin-resistant skeletal muscle is characterized by metabolic inflexibility with associated alterations in substrate selection, mediated by peroxisome-proliferator activated receptor δ (PPARδ).
Nicola Lai, Nicola Lai, Nicola Lai, Nicola Lai, Nicola Lai, Ciarán E. Fealy, Chinna M. Kummitha, Silvia Cabras, John P. Kirwan, John P. Kirwan, John P. Kirwan, Charles L. Hoppel, Charles L. Hoppel, Charles L. Hoppel   +13 more
doaj   +1 more source

Metabolic Flexibility in Leukemia—Adapt or Die [PDF]

Cancer Cell, 2018
In this issue of Cancer Cell, Jones et al. demonstrate that LSCs are metabolically inflexible. LSCs rely on amino acid metabolism to fuel oxidative phosphorylation and cannot compensate with other fuel sources following amino acid depletion. Combined venetoclax and azacitidine reduces amino acid uptake, partly explaining the anti-LSC effects.
Boaz, Nachmias, Aaron D, Schimmer
openaire   +2 more sources

Metabolic flexibility and insulin resistance

American Journal of Physiology-Endocrinology and Metabolism, 2008
Metabolic flexibility is the capacity for the organism to adapt fuel oxidation to fuel availability. The inability to modify fuel oxidation in response to changes in nutrient availability has been implicated in the accumulation of intramyocellular lipid and insulin resistance.
Galgani Fuentes, José, Moro, Cedric, Ravussin, Eric   +2 more
openaire   +4 more sources