Results 21 to 30 of about 1,689,302 (242)

MED13‐dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver

EMBO Molecular Medicine, 2014
The heart requires a continuous supply of energy but has little capacity for energy storage and thus relies on exogenous metabolic sources. We previously showed that cardiac MED13 modulates systemic energy homeostasis in mice.
Kedryn K Baskin, Chad E Grueter, Christine M Kusminski, William L Holland, Angie L Bookout, Santosh Satapati, Y Megan Kong, Shawn C Burgess, Craig R Malloy, Philipp E Scherer, Christopher B Newgard, Rhonda Bassel‐Duby, Eric N Olson   +12 more
doaj   +1 more source

Relationships between mitochondrial function and metabolic flexibility in type 2 diabetes mellitus. [PDF]

, 2013
INTRODUCTION: Mitochondrial dysfunction, lipid accumulation, insulin resistance and metabolic inflexibility have been implicated in the etiology of type 2 diabetes (T2D), yet their interrelationship remains speculative.
Schrauwen, P., van Herpen, N.A., Schrauwen-Hinderling, V.B., Noud Antonius van Herpen, Hesselink, M.K., Lauren Marie Sparks, Ruth Carla Meex, van de Weijer, T., Tineke van de Weijer, Matthijs Karel C Hesselink, Vera Bettina Schrauwen-Hinderling, Meex, R.C., Meex, R.C.; id_orcid, Esther Phielix, Sparks, L.M., Patrick Schrauwen, Phielix, E.   +16 more
core   +1 more source

Prehabilitation: Do We Need Metabolic Flexibility? [PDF]

Ann Nutr Metab
Metabolic flexibility, the capacity to switch between energy sources in response to changing physiological demands, emerges as a critical determinant of perioperative resilience.
Tetlow N, Whittle J.
europepmc   +3 more sources

Metabolic flexibility as an adaptation to energy resources and requirements in health and disease

, 2018
The ability to efficiently adapt metabolism by substrate sensing, trafficking, storage, and utilization, dependent on availability and requirement, is known as metabolic flexibility.
Reuben L Smith, Rob C I Wüst, Riekelt H Houtkooper, Wüst, Rob C. I., Wüst, Rob C I; id_orcid, Smith, Reuben L., Soeters, Maarten R., Maarten R Soeters, Soeters, Maarten R, Houtkooper, Riekelt H., Wüst, Rob C I, Smith, Reuben L, Houtkooper, Riekelt H   +12 more
core   +1 more source

Passive Heat Stimuli as a Systemic Training in Elite Endurance Athletes: A New Strategy to Promote Greater Metabolic Flexibility

Journal of Functional Morphology and Kinesiology
Objectives: The ability to efficiently regulate body temperature is crucial during endurance activities such as trail running, especially during competitive events in hot conditions.
Sergi Cinca-Morros, Martin Burtscher, Fernando Benito-Lopez, Jesús Álvarez-Herms   +3 more
doaj   +1 more source

Physiological Perturbations in Combat Sports: Weight Cycling and Metabolic Function—A Narrative Review

Metabolites
Combat sports athletes seeking a competitive edge often engage in weight management practices to become larger than their opponents, which ultimately includes periods of gradual weight loss, rapid weight loss, and weight regain.
Modesto A. Lebron, Jeffrey R. Stout, David H. Fukuda   +2 more
doaj   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Impact des traits d’histoire de vie du microcèbe (Microcebus murinus) dans la régulation du métabolisme en réponse à l’environnement

Revue de Primatologie
The grey mouse lemur is a primate endemic from Madagascar, which environmental conditions can vary from season to season, both predictably and unpredictably. To survive such difficult conditions, this small primate (weighing less than 100g) has developed
Jérémy Terrien
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Prediction of manufacturing flexibility by the use of simulation modelling

, 1997
Flexibility is seen as a desirable attribute of a manufacturing system. Virtually every manufacturing organisation wants it, but find it difficult to define, predict or measure. Most researchers look inwards to try to obtain measures.
Matupi, Newton B.
core   +7 more sources