Results 11 to 20 of about 116,098 (154)

PFKFB2 Is Pivotal for Metabolic Flexibility and Differential Glucose Utilization [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The heart’s constant energy demands make metabolic flexibility critical to its function as nutrient availability varies. The enzyme phosphofructokinase‐2/fructose 2,6‐bisphosphatase (PFKFB2) contributes to this flexibility by acting as a ...
Kylene M. Harold, Satoshi Matsuzaki, Atul Pranay, Jie Zhu, Anna Faakye, Kenneth M. Humphries   +5 more
doaj   +2 more sources

Unlocking metabolic flexibility in heart failure with preserved ejection fraction: Bridging fundamental mechanisms to clinical innovation [PDF]

iScience
Summary: Heart failure is often described as a condition of “energy depletion.” However, in heart failure with preserved ejection fraction (HFpEF), particularly when associated with metabolic conditions such as obesity and diabetes, the heart may face a ...
Junyan Xia, Yibing Nong, Jun Teng, Shafeeq A. Mohammed, Jing Liu, Yanting Pang, Sarah Costantino, Frank Ruschitzka, Nazha Hamdani, Mahmoud Abdellatif, Qian Lin, Francesco Paneni   +11 more
doaj   +2 more sources

Metabolic Flexibility of Microglia: Energy Substrate Utilization and Impact on Neuronal Metabolism. [PDF]

J Neurochem
ABSTRACT Microglia, the main resident immune cells of the brain, play critical roles in maintaining neuronal function and homeostasis. Microglia's metabolic flexibility enables rapid adaptation to environmental changes, yet the full extent of their metabolic capabilities and influence on neuronal metabolism ...
Westi EW, Carlsen RB, Andersen JV, Kilic Z, Alnajar D, Holmgaard NK, Sintes BG, Cota-Coronado A, Muñoz SS, Galvagnion C, Aldana BI.   +10 more
europepmc   +3 more sources

Metabolic flexibility [PDF]

Proceedings of the Nutrition Society, 2004
Human physiology needs to be well adapted to cope with major discontinuities in both the supply of and demand for energy. This adaptability requires ‘a clear capacity to utilize lipid and carbohydrate fuels and to transition between them’ ( Kelley et al. 2002b).
Len, Storlien, Nick D, Oakes, David E, Kelley   +2 more
openaire   +2 more sources

Mitochondrial Phenotype as a Driver of the Racial Dichotomy in Obesity and Insulin Resistance

Biomedicines, 2022
African Americans (AA) are disproportionately burdened by metabolic diseases. While largely unexplored between Caucasian (C) and AA, differences in mitochondrial bioenergetics may provide crucial insight to mechanisms for increased susceptibility to ...
Filip Jevtovic, Polina M. Krassovskaia, Christian A. Lopez, Kelsey H. Fisher-Wellman, Ronald N. Cortright, Nicholas T. Broskey   +5 more
doaj   +1 more source

VDAC Modulation of Cancer Metabolism: Advances and Therapeutic Challenges

Frontiers in Physiology, 2021
Most anionic metabolites including respiratory substrates, glycolytic adenosine triphosphate (ATP), and small cations that enter mitochondria, and mitochondrial ATP moving to the cytosol, cross the outer mitochondrial membrane (OMM) through voltage ...
Kareem A. Heslop, Veronica Milesi, Eduardo N. Maldonado, Eduardo N. Maldonado   +3 more
doaj   +1 more source

Chronic Lactate Exposure Decreases Mitochondrial Function by Inhibition of Fatty Acid Uptake and Cardiolipin Alterations in Neonatal Rat Cardiomyocytes

Frontiers in Nutrition, 2022
IntroductionLactate is an important signaling molecule with autocrine, paracrine and endocrine properties involved in multiple biological processes including regulation of gene expression and metabolism.
Iñigo San-Millan, Iñigo San-Millan, Iñigo San-Millan, Genevieve C. Sparagna, Hailey L. Chapman, Valerie L. Warkins, Kathryn C. Chatfield, Sydney R. Shuff, Janel L. Martinez, George A. Brooks   +9 more
doaj   +1 more source

C1QBP regulates mitochondrial plasticity to impact tumor progression and antitumor immune response

Frontiers in Physiology, 2022
Mitochondrial plasticity including mitochondrial dynamics, metabolic flexibility, and mitochondrial quality control, impact tumor cells’ progression and determine immune cells’ fate.
Qiping Wang, Dafei Chai, Navid Sobhani, Nan Sun, Nan Sun, Nan Sun, Praveen Neeli, Junnian Zheng, Junnian Zheng, Hui Tian, Hui Tian, Hui Tian   +11 more
doaj   +1 more source

Glucose metabolism and metabolic flexibility in blood platelets [PDF]

Journal of Thrombosis and Haemostasis, 2018
Essentials The metabolic integration processes required for platelet activation are unclear. The metabolic plasticity of human platelets were investigated. Activated platelets exhibit a glycolytic phenotype while preserving mitochondrial function. Platelets can switch freely between glucose/glycogen and fatty acids to support aggregation.
Aibibula, M., Naseem, K. M., Sturmey, R.
openaire   +4 more sources

Female Mice Are Protected from Metabolic Decline Associated with Lack of Skeletal Muscle HuR

Biology, 2021
Male mice lacking HuR in skeletal muscle (HuRm−/−) have been shown to have decreased gastrocnemius lipid oxidation and increased adiposity and insulin resistance. The same consequences have not been documented in female HuRm−/− mice. Here we examine this
Allison C. Stone, Robert C. Noland, Randall L. Mynatt, Samuel E. Velasquez, David S. Bayless, Eric Ravussin, Jaycob D. Warfel   +6 more
doaj   +1 more source