Results 11 to 20 of about 1,689,302 (242)

Simulating Metabolic Flexibility in Low Energy Expenditure Conditions Using Genome-Scale Metabolic Models [PDF]

Metabolites, 2021
Metabolic flexibility is the ability of an organism to adapt its energy source based on nutrient availability and energy requirements. In humans, this ability has been linked to cardio-metabolic health and healthy aging.
Andrea Cabbia, Peter A. J. Hilbers, Natal A. W. van Riel   +2 more
doaj   +3 more sources

Exploring metabolic pathway disruption in the subchronic phencyclidine model of schizophrenia with the generalized singular value decomposition [PDF]

, 2011
The quantification of experimentally-induced alterations in biological pathways remains a major challenge in systems biology. One example of this is the quantitative characterization of alterations in defined, established metabolic pathways from complex ...
Dawson, Neil, MacIntyre, Lynsey, Xiao, Xiaolin, Watson, David, Higham, Desmond, Pratt, Judith, Morris, Brian   +6 more
core   +6 more sources

Metabolic fluxes for nutritional flexibility of Mycobacterium tuberculosis [PDF]

, 2021
The co‐catabolism of multiple host‐derived carbon substrates is required by Mycobacterium tuberculosis (Mtb) to successfully sustain a tuberculosis infection. However, the metabolic plasticity of this pathogen and the complexity of the metabolic networks
V Trevor Forsyth, Martine Moulin, Mendum, Tom A, Gerald Larrouy‐Maumus, Tom A Mendum, McFadden, J., Harald Pichler, Jane L Ward, Borah, Khushboo, Dany J V Beste, Noack, S., Strohmeier, Gernot, Goulding, C. V., Ward, J. L., Bhatt, Apoorva; id_orcid, Mendum, T. A., Larrouy-Maumus, G., Pichler, H., Beale, M. H., Beste, Dany JV, Stephan Noack, Moulin, M., Nathaniel D Hawkins, Beste, D. J. V., Noack, Stephan, Bhatt, A., Moulin, Martine, Pichler, Harald, Haertlein, M., Goulding, Celia W, Beale, Michael H, Apoorva Bhatt, Michael H Beale, Ward, Jane L, Hawkins, Nathaniel D, Bhatt, Apoorva, Beste, Dany J V, Gernot Strohmeier, Hawkins, N. D., Haertlein, Michael, Celia W Goulding, Borah, K., Johnjoe McFadden, Khushboo Borah, Strohmeier, G., Larrouy-Maumus, Gerald, Forsyth, V. T., McFadden, Johnjoe, Forsyth, V Trevor, Michael Haertlein, Larrouy‐Maumus, Gerald, BESTE, DANY   +51 more
core   +1 more source

Metabolic flexibility and insulin resistance [PDF]

, 2008
Metabolic flexibility is the capacity for the organism to adapt fuel oxidation to fuel availability. The inability to modify fuel oxidation in response to changes in nutrient availability has been implicated in the accumulation of intramyocellular lipid ...
Galgani Fuentes, José, Moro, Cedric, Ravussin, Eric   +2 more
core   +1 more source

Mitochondrial response to nutrient availability and its role in metabolic disease [PDF]

, 2014
Metabolic inflexibility is defined as an impaired capacity to switch between different energy substrates and is a hallmark of insulin resistance and type 2 diabetes mellitus (T2DM).
Carles Cantó, Gao, Arwen W., Arwen W Gao, Houtkooper, Riekelt H., Riekelt H Houtkooper, Cantó, Carles   +5 more
core   +1 more source

Energetic Contributions Including Gender Differences and Metabolic Flexibility in the General Population and Athletes

, 2022
Metabolic flexibility includes the ability to perform fat and carbohydrate oxidation, as well as oxidative capacity, which is associated with mitochondrial function, energetic contributions, and physical health and performance. During a session of graded
Park, Yongdoo, Woo-Hwi Yang, Park, Jeong-Hyun, Jeong-Hyun Park, Park, So-Young, Yongdoo Park, So-Young Park, Yang, Woo-Hwi   +7 more
core   +1 more source

Metabolic Flexibility in Non-Obese Individuals

, 2020
Human skeletal muscle cells have been used as a tool to study and understand skeletal muscle metabolism due to their retention in characteristics from their donor.
Khang, Nkaujyi, NC DOCKS at East Carolina University   +1 more
core   +2 more sources

L-Carnitine and Acylcarnitines: Mitochondrial Biomarkers for Precision Medicine

Metabolites, 2021
Biomarker discovery and implementation are at the forefront of the precision medicine movement. Modern advances in the field of metabolomics afford the opportunity to readily identify new metabolite biomarkers across a wide array of disciplines.
Marc R. McCann, Mery Vet George De la Rosa, Gus R. Rosania, Kathleen A. Stringer   +3 more
doaj   +1 more source

Post-exercise Warm or Cold Water Immersion to Augment the Cardiometabolic Benefits of Exercise Training: A Proof of Concept Trial

Frontiers in Physiology, 2021
We investigated whether substituting the final half within 60-min bouts of exercise with passive warm or cold water immersion would provide similar or greater benefits for cardiometabolic health.
Brooke M. Russell, Brooke M. Russell, Courtney R. Chang, Courtney R. Chang, Terry Hill, James D. Cotter, Monique E. Francois, Monique E. Francois   +7 more
doaj   +1 more source

Mitochondrial Utilization of Competing Fuels Is Altered in Insulin Resistant Skeletal Muscle of Non-obese Rats (Goto-Kakizaki)

Frontiers in Physiology, 2020
AimInsulin-resistant skeletal muscle is characterized by metabolic inflexibility with associated alterations in substrate selection, mediated by peroxisome-proliferator activated receptor δ (PPARδ).
Nicola Lai, Nicola Lai, Nicola Lai, Nicola Lai, Nicola Lai, Ciarán E. Fealy, Chinna M. Kummitha, Silvia Cabras, John P. Kirwan, John P. Kirwan, John P. Kirwan, Charles L. Hoppel, Charles L. Hoppel, Charles L. Hoppel   +13 more
doaj   +1 more source