Results 31 to 40 of about 116,098 (154)

Metabolic Flexibility and Dysfunction in Cardiovascular Cells [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2015
Cardiovascular cells that contribute directly to atherosclerosis and cardiac dysfunction are known to exhibit metabolic flexibility, characterized by the ability to switch from generating ATP primarily through oxidative phosphorylation to using glycolysis as the predominate energy source, and to shift from one fuel source to another.
Sara N, Vallerie, Karin E, Bornfeldt
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Metabolic fluxes for nutritional flexibility of Mycobacterium tuberculosis [PDF]

Molecular Systems Biology, 2021
Abstract The co‐catabolism of multiple host‐derived carbon substrates is required by Mycobacterium tuberculosis (Mtb) to successfully sustain a tuberculosis infection. However, the metabolic plasticity of this pathogen and the complexity of the metabolic networks present a ...
Borah, Khushboo, Mendum, Tom A, Hawkins, Nathaniel D, Ward, Jane L, Beale, Michael H, Larrouy‐Maumus, Gerald, Bhatt, Apoorva, Moulin, Martine, Haertlein, Michael, Strohmeier, Gernot, Pichler, Harald, Forsyth, V Trevor, Noack, Stephan, Goulding, Celia W, McFadden, Johnjoe, BESTE, DANY, Beste, Dany J V   +16 more
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MED13‐dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver

EMBO Molecular Medicine, 2014
The heart requires a continuous supply of energy but has little capacity for energy storage and thus relies on exogenous metabolic sources. We previously showed that cardiac MED13 modulates systemic energy homeostasis in mice.
Kedryn K Baskin, Chad E Grueter, Christine M Kusminski, William L Holland, Angie L Bookout, Santosh Satapati, Y Megan Kong, Shawn C Burgess, Craig R Malloy, Philipp E Scherer, Christopher B Newgard, Rhonda Bassel‐Duby, Eric N Olson   +12 more
doaj   +1 more source

Flexible tumor metabolism [PDF]

The Journal of Cell Biology, 2006
Tumor cells can survive the hypoxia in the center of tumor masses by using glycolysis, rather than oxidative phosphorylation, to generate energy. Most tumor cells also stick to glycolysis when normally oxygenated.
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Retained Metabolic Flexibility of the Failing Human Heart

Circulation, 2023
Background: The failing heart is traditionally described as metabolically inflexible and oxygen starved, causing energetic deficit and contractile dysfunction. Current metabolic modulator therapies aim to increase glucose oxidation to increase oxygen efficiency of adenosine triphosphate production, with mixed results.
Watson, WD, Green, PG, Lewis, AJM, Arvidsson, P, De Maria, GL, Arheden, H, Heiberg, E, Clarke, WT, Rodgers, CT, Valkovič, L, Neubauer, S, Herring, N, Rider, OJ   +12 more
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How to starve cancer cells when nutrients are abundant

Molecular & Cellular Oncology, 2020
Metabolic flexibility represents a potential point of attack for novel cancer treatments. We recently described the signaling mechanism inducing a metabolic shift in response to metformin and phenformin in leukemia and lymphoma cells.
Hamidullah Khan, Stefan M. Schieke
doaj   +1 more source

The Metabolic Flexibility of Hovering Vertebrate Nectarivores [PDF]

Physiology, 2018
Foraging hummingbirds and nectar bats oxidize both glucose and fructose from nectar at exceptionally high rates. Rapid sugar flux is made possible by adaptations to digestive, cardiovascular, and metabolic physiology affecting shared and distinct pathways for the processing of each sugar.
Kenneth C. Welch, Alexander M. Myrka, Raafay Syed Ali, Morag F. Dick   +3 more
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Passive Heat Stimuli as a Systemic Training in Elite Endurance Athletes: A New Strategy to Promote Greater Metabolic Flexibility

Journal of Functional Morphology and Kinesiology
Objectives: The ability to efficiently regulate body temperature is crucial during endurance activities such as trail running, especially during competitive events in hot conditions.
Sergi Cinca-Morros, Martin Burtscher, Fernando Benito-Lopez, Jesús Álvarez-Herms   +3 more
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Exercise-Induced Improvements in Insulin Sensitivity Are Not Attenuated by a Family History of Type 2 Diabetes

Frontiers in Endocrinology, 2020
Introduction: A family history of type 2 diabetes (FH+) is a major risk factor for the development of insulin resistance and type 2 diabetes. However, it remains unknown whether exercise-induced improvements in insulin sensitivity and metabolic ...
Manuel Amador, Cesar A. Meza, Andrew J. McAinch, Andrew J. McAinch, George A. King, Jeffrey D. Covington, Sudip Bajpeyi   +6 more
doaj   +1 more source

Physiological Perturbations in Combat Sports: Weight Cycling and Metabolic Function—A Narrative Review

Metabolites
Combat sports athletes seeking a competitive edge often engage in weight management practices to become larger than their opponents, which ultimately includes periods of gradual weight loss, rapid weight loss, and weight regain.
Modesto A. Lebron, Jeffrey R. Stout, David H. Fukuda   +2 more
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