Results 51 to 60 of about 1,689,302 (242)

Metabolic switching of human myotubes is improved by n-3 fatty acids

Journal of Lipid Research, 2010
The aim of the present study was to examine whether pretreatment with different fatty acids, as well as the liver X receptor (LXR) agonist T0901317, could modify metabolic switching of human myotubes.
N.P. Hessvik, S.S. Bakke, K. Fredriksson, M.V. Boekschoten, A. Fj⊘rkenstad, G. Koster, M.K. Hesselink, S. Kersten, E.T. Kase, A.C. Rustan, G.H. Thoresen   +10 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The interaction between metabolic disease and ageing [PDF]

, 2014
Two of the greatest crises that civilisation faces in the 21st century are the predicted rapid increases in the ageing population and levels of metabolic disorders such as obesity and type 2 diabetes.
Brown, James, Navas, Placido, Helen R. Griffiths, James E. Brown, Rana, Karan S., Karan S. Rana, Placido Navas, Griffiths, Helen R.   +7 more
core   +1 more source

Integrative genome-scale metabolic model of GABAergic neurons reveals metabolic signatures across the mild cognitive impairment – Alzheimer disease continuum

Frontiers in Systems Biology
IntroductionMild cognitive impairment (MCI) represents a prodromal stage of Alzheimer’s disease (AD), but the metabolic mechanisms underlying early neuronal dysfunction remain incompletely understood.
Andrea Angarita-Rodríguez, Andrea Angarita-Rodríguez, Johan H. Largo-González, Johan H. Largo-González, Julián Pérez-Mejía, Daniel Balcazar, Viviana Vargas-López, Jason A. Papin, Jason A. Papin, Jason A. Papin, Andrés Pinzón, Janneth González   +11 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Tumor organoids for testing metabolic flexibility in precision oncology

Frontiers in Oncology
Tumors adapt their metabolism to fluctuating nutrients, hypoxia, stromal interactions, immune pressure, and treatment. Tumor organoids are attractive systems in which to test this flexibility, but existing reviews have largely emphasized organoid ...
Di Hao, Yijie Ren, Hui Zhang
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

The Effect of Aging on Metabolic Flexibility

, 2019
Introduction: Metabolic flexibility refers to one’s ability to adjust their oxidation of carbohydrates and fats and differs with exercise training and between healthy and diseased populations.
Jones, Caleb
core   +1 more source

Editorial: Metabolic Flexibility

Frontiers in Nutrition, 2022
Jose E. Galgani, Jose E. Galgani, Audrey Bergouignan, Audrey Bergouignan, Jennifer Rieusset, Cedric Moro, Julie-Anne Nazare, Julie-Anne Nazare   +7 more
doaj   +1 more source