Results 51 to 60 of about 116,098 (154)
Cells, 2022 Cells have metabolic flexibility that allows them to adapt to changes in substrate availability. Two highly relevant metabolites are glucose and fatty acids (FA), and hence, glycolysis and fatty acid oxidation (FAO) are key metabolic pathways leading to ...
Abrar Ul Haq Khan +10 more
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Understanding Metabolic Alterations in Cancer Cachexia through the Lens of Exercise Physiology
Cells, 2022 Cancer cachexia is one of the leading causes of mortality for late-stage cancer patients. One of its key characteristics is abnormal metabolism and loss of metabolic flexibility, i.e., loss of ability to switch between use of fats and carbohydrates as ...
Irina Kareva
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Journal of the International Society of Sports NutritionBackground Impaired fat oxidation is linked to cardiometabolic risk. Maximal fat oxidation rate (MFO) reflects metabolic flexibility and is influenced by lean mass, muscle strength, muscle quality – defined as the ratio of strength to mass – and ...
Edgardo Opazo-Díaz +8 more
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ReceptorsNutrient-sensing nuclear receptors (NSNRs), including PPARs, FXR, LXRs, RAR/RXR, VDR, and related orphan receptors, integrate a molecular interface that allows diet to communicate directly with the genome.
Ivan Torre-Villalvazo +3 more
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Male mouse skeletal muscle lacking HuR shows enhanced glucose disposal at a young age
Frontiers in PhysiologyIntroductionMetabolic flexibility is the ability of a system to switch between metabolic substrates. Human and murine skeletal muscle tissues and cells with decreased activity of the regulatory RNA-binding protein, human antigen R (HuR), have decreased ...
Robert C. Noland +13 more
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Mitochondrial response to nutrient availability and its role in metabolic disease
EMBO Molecular Medicine, 2014 Metabolic inflexibility is defined as an impaired capacity to switch between different energy substrates and is a hallmark of insulin resistance and type 2 diabetes mellitus (T2DM).
Arwen W Gao +2 more
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Improving flexibility in substrate metabolism
, 2022 Overweight increases the risk of cancer, non-alcoholic fatty liver disease, cardiovascular disease, and the development of diabetes type 2. These metabolic diseases are characterised by less pronounced carbohydrate and fat oxidation fluctuations over 24 hours.
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Methanogenic archaea and sulfate reducing bacteria co-cultured on acetate: teamwork or coexistence?
Frontiers in Microbiology, 2015 Acetate is a major product of fermentation processes and an important substrate for sulfate reducing bacteria and methanogenic archaea. Most studies on acetate catabolism by sulfate reducers and methanogens have used pure cultures.
Derya eOzuolmez +5 more
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Metabolic Flexibility: Hibernation, Torpor, and Estivation
Comprehensive Physiology, 2016 ABSTRACT Many environmental conditions can constrain the ability of animals to obtain sufficient food energy, or transform that food energy into useful chemical forms. To survive extended periods under such conditions animals must suppress metabolic rate to conserve energy, water, or oxygen.
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Metabolic and Neuroendocrine Responses to Intermittent Fasting in Obesity
MedicinaBackground and Objectives: Intermittent fasting (IF) has emerged as a nutritional strategy capable of modulating circadian alignment, metabolic efficiency, and neuroendocrine regulation in individuals with obesity.
Salvatore Allocca +12 more
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