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Perspectives on whole body and tissue-specific metabolic flexibility and implications in cardiometabolic diseases [PDF]
Cell Reports MedicineSummary: Metabolic flexibility is the body’s ability to switch between fuel sources in response to changing supply. This adaptability is crucial for maintaining energy balance and metabolic homeostasis, involving key processes like insulin signaling ...
Jia-Hui Christy Ang +6 more
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Metabolic Flexibility of Sulfate Reducing Bacteria
Frontiers in Microbiology, 2011 Dissimilatory sulfate-reducing prokaryotes (SRB) are a very diverse group of anaerobic bacteria that are omnipresent in nature and play an imperative role in the global cycling of carbon and sulfur.
Caroline M. Plugge +3 more
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Impaired Metabolic Flexibility in the Osteoarthritis Process: A Study on Transmitochondrial Cybrids
Cells, 2020 Osteoarthritis (OA) is the most frequent joint disease; however, the etiopathogenesis is still unclear. Chondrocytes rely primarily on glycolysis to meet cellular energy demand, but studies implicate impaired mitochondrial function in OA pathogenesis ...
Andrea Dalmao-Fernández +6 more
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Metabolic flexibility during sleep
Scientific Reports, 2021 Known as metabolic flexibility, oxidized substrate is selected in response to changes in the nutritional state. Sleep imposes an extended duration of fasting, and oxidized substrates during sleep were assumed to progressively shift from carbohydrate to ...
Simeng Zhang +12 more
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Mitochondrial Phenotype as a Driver of the Racial Dichotomy in Obesity and Insulin Resistance
Biomedicines, 2022 African Americans (AA) are disproportionately burdened by metabolic diseases. While largely unexplored between Caucasian (C) and AA, differences in mitochondrial bioenergetics may provide crucial insight to mechanisms for increased susceptibility to ...
Filip Jevtovic +5 more
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VDAC Modulation of Cancer Metabolism: Advances and Therapeutic Challenges
Frontiers in Physiology, 2021 Most anionic metabolites including respiratory substrates, glycolytic adenosine triphosphate (ATP), and small cations that enter mitochondria, and mitochondrial ATP moving to the cytosol, cross the outer mitochondrial membrane (OMM) through voltage ...
Kareem A. Heslop +3 more
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Frontiers in Nutrition, 2022 IntroductionLactate is an important signaling molecule with autocrine, paracrine and endocrine properties involved in multiple biological processes including regulation of gene expression and metabolism.
Iñigo San-Millan +9 more
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Cells, 2020 Energy balance, mitochondrial dysfunction, obesity, and insulin resistance are disrupted by metabolic inflexibility while therapeutic interventions are associated with improved glucose/lipid metabolism in skeletal muscle. Conjugated linoleic acid mixture
Giovanna Trinchese +11 more
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C1QBP regulates mitochondrial plasticity to impact tumor progression and antitumor immune response
Frontiers in Physiology, 2022 Mitochondrial plasticity including mitochondrial dynamics, metabolic flexibility, and mitochondrial quality control, impact tumor cells’ progression and determine immune cells’ fate.
Qiping Wang +11 more
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Female Mice Are Protected from Metabolic Decline Associated with Lack of Skeletal Muscle HuR
Biology, 2021 Male mice lacking HuR in skeletal muscle (HuRm−/−) have been shown to have decreased gastrocnemius lipid oxidation and increased adiposity and insulin resistance. The same consequences have not been documented in female HuRm−/− mice. Here we examine this
Allison C. Stone +6 more
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