Results 21 to 30 of about 898,161 (347)
Frontiers in Pharmacology, 2021 Prucalopride was widely used for chronic constipation, which is difficult to be adequately relieved by laxatives in adult patients in clinic. Due to the difficulty in metabolite identification, metabolic process of prucalopride had not been investigated ...
Lihua Zuo +16 more
doaj +1 more source
Structure and function of negative feedback loops at the interface of genetic and metabolic networks [PDF]
, 2006 The molecular network in an organism consists of transcription/translation regulation, protein-protein interactions/modifications and a metabolic network, together forming a system that allows the cell to respond sensibly to the multiple signal molecules
Andersson, Anna M. C. +3 more
core +4 more sources
Microbial diversity and metabolic networks in acid mine drainage habitats
Frontiers in Microbiology, 2015 Acid mine drainage (AMD) emplacements are low-complexity natural systems. Low-pH conditions appear to be the main factor underlying the limited diversity of the microbial populations thriving in these environments, although temperature, ionic composition,
Celia eMendez-Garcia +6 more
doaj +1 more source
What mRNA Abundances Can Tell us about Metabolism
Metabolites, 2012 Inferring decreased or increased metabolic functions from transcript profiles is at first sight a bold and speculative attempt because of the functional layers in between: proteins, enzymatic activities, and reaction fluxes. However, the growing interest
Andreas Hoppe
doaj +1 more source
Quantifying biosynthetic network robustness across the human oral microbiome [PDF]
, 2018 Metabolic interactions, such as cross-feeding, play a prominent role in microbial communitystructure. For example, they may underlie the ubiquity of uncultivated microorganisms.
Bernstein, David +2 more
core +1 more source
Use of a global metabolic network to curate organismal metabolic networks [PDF]
Scientific Reports, 2013 The difficulty in annotating the vast amounts of biological information poses one of the greatest current challenges in biological research. The number of genomic, proteomic, and metabolomic datasets has increased dramatically over the last two decades, far outstripping the pace of curation efforts.
A. R. Pah +3 more
openaire +2 more sources
Network Architecture and Mutational Sensitivity of the C. elegans Metabolome
Frontiers in Molecular Biosciences, 2018 A fundamental issue in evolutionary systems biology is understanding the relationship between the topological architecture of a biological network, such as a metabolic network, and the evolution of the network. The rate at which an element in a metabolic
Lindsay M. Johnson +4 more
doaj +1 more source
Periodic ethanol supply as a path toward unlimited lifespan of Caenorhabditis elegans dauer larvae
Frontiers in Aging, 2023 The dauer larva is a specialized stage of worm development optimized for survival under harsh conditions that have been used as a model for stress resistance, metabolic adaptations, and longevity.
Xingyu Zhang +6 more
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Why Optimal States Recruit Fewer Reactions in Metabolic Networks [PDF]
, 2012 The metabolic network of a living cell involves several hundreds or thousands of interconnected biochemical reactions. Previous research has shown that under realistic conditions only a fraction of these reactions is concurrently active in any given cell.
Lee, Joo Sang +2 more
core +1 more source
Quantitative proteomic analysis reveals a simple strategy of global resource allocation in bacteria
Molecular Systems Biology, 2015 A central aim of cell biology was to understand the strategy of gene expression in response to the environment. Here, we study gene expression response to metabolic challenges in exponentially growing Escherichia coli using mass spectrometry.
Sheng Hui +7 more
doaj +1 more source