Results 31 to 40 of about 911,565 (297)

Metabolic network modularity arising from simple growth processes

, 2012
Metabolic networks consist of linked functional components, or modules. The mechanism underlying metabolic network modularity is of great interest not only to researchers of basic science but also to those in fields of engineering.
Takemoto, Kazuhiro
core   +1 more source

Genome-Scale Metabolic Reconstruction and in Silico Perturbation Analysis of the Polar Diatom Fragilariopsis cylindrus Predicts High Metabolic Robustness

Biology, 2020
Diatoms are major primary producers in polar environments where they can actively grow under extremely variable conditions. Integrative modeling using a genome-scale model (GSM) is a powerful approach to decipher the complex interactions between ...
Michel Lavoie, Blanche Saint-Béat, Jan Strauss, Sébastien Guérin, Antoine Allard, Simon V. Hardy, Angela Falciatore, Johann Lavaud   +7 more
doaj   +1 more source

Stage-dependent differential influence of metabolic and structural networks on memory across Alzheimer’s disease continuum

eLife, 2022
Background: Large-scale neuronal network breakdown underlies memory impairment in Alzheimer’s disease (AD). However, the differential trajectories of the relationships between network organisation and memory across pathology and cognitive stages in AD ...
Kok Pin Ng, Xing Qian, Kwun Kei Ng, Fang Ji, Pedro Rosa-Neto, Serge Gauthier, Nagaendran Kandiah, Juan Helen Zhou, Alzheimer's Disease Neuroimaging Initiative   +8 more
doaj   +1 more source

Heterosis Is a Systemic Property Emerging From Non-linear Genotype-Phenotype Relationships: Evidence From in Vitro Genetics and Computer Simulations

Frontiers in Genetics, 2018
Heterosis, the superiority of hybrids over their parents for quantitative traits, represents a crucial issue in plant and animal breeding as well as evolutionary biology.
Julie B. Fiévet, Thibault Nidelet, Christine Dillmann, Dominique de Vienne   +3 more
doaj   +1 more source

Quantifying biosynthetic network robustness across the human oral microbiome [PDF]

, 2018
Metabolic interactions, such as cross-feeding, play a prominent role in microbial communitystructure. For example, they may underlie the ubiquity of uncultivated microorganisms.
Bernstein, David, Dewhirst, Floyd, Segre, Daniel   +2 more
core   +1 more source

A Metabolic Network Mediating the Cycling of Succinate, a Product of ROS Detoxification into α-Ketoglutarate, an Antioxidant

Antioxidants, 2022
Sulfur is an essential element for life. However, the soil microbe Pseudomonas (P.) fluorescens can survive in a low sulfur environment. When cultured in a sulfur-deficient medium, the bacterium reprograms its metabolic pathways to produce α ...
Félix Legendre, Alex MacLean, Sujeenthar Tharmalingam, Vasu D. Appanna   +3 more
doaj   +1 more source

Prevalence of metabolic syndrome in baluch women in Chabahar [PDF]

, 2015
Epidemiological studies have shown the importance of the metabolic syndrome. With estimation of the metabolic syndrome, it may predict cardiovascular disease, sudden death and the presence of some other cardiovascular risk factors.
Majidi, F., Marjani, A., Naseri, F., Paad, E., Tabari, M.G.   +4 more
core   +1 more source

Integrated Metabolomic and Network Analysis to Explore the Potential Mechanism of Three Chemical Elicitors in Rapamycin Overproduction

Microorganisms, 2022
Rapamycin is a polyketide macrocyclic antibiotic with exceptional pharmacological potential. To explore the potential mechanism of rapamycin overproduction, the intracellular metabolic differences of three chemical elicitor treatments were first ...
Dandan Zhang, Jinyu Chen, Zihui Wang, Cheng Wang   +3 more
doaj   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Identification and Validation of Metabolic Markers for Adulteration Detection of Edible Oils Using Metabolic Networks

Metabolites, 2020
Food adulteration is a challenge faced by consumers and researchers. Due to DNA fragmentation during oil processing, it is necessary to discover metabolic markers alternative to DNA for adulteration detection of edible oils.
Xinjing Dou, Liangxiao Zhang, Xiao Wang, Ruinan Yang, Xuefang Wang, Fei Ma, Li Yu, Jin Mao, Hui Li, Xiupin Wang, Peiwu Li   +10 more
doaj   +1 more source