Results 21 to 30 of about 911,565 (297)

MultiMetEval: comparative and multi-objective analysis of genome-scale metabolic models [PDF]

, 2012
Comparative metabolic modelling is emerging as a novel field, supported by the development of reliable and standardized approaches for constructing genome-scale metabolic models in high throughput.
A Freitag, A Gevorgyan, A Mithani, Albert Gevorgyan, AM Feist, AM Feist, AM Feist, Andrzej M. Kierzek, AP Burgard, BA Pfeifer, CS Henry, D Nagrath, DC Alexander, DC Stevens, EM Paradise, Eriko Takano, FC Lee, H Ikeda, I Thiele, J Gonzalez-Lergier, J Romero, J Schellenberger, JD Orth, JL Adrio, JP Brooks, JS Edwards, K Nieselt, K Yanai, LM Blank, M DeJongh, M Durot, M Kanehisa, M Latendresse, MA Fischbach, MA Oberhardt, MA Oberhardt, MA Oberhardt, Marnix H. Medema, MH Medema, MH Medema, MH Medema, MH Medema, MT Alam, MT Alam, MW Covert, N Scherr, ND Price, ND Price, NE Lewis, Piotr Zakrzewski, PR Ives, R Breitling, R Schuetz, Rainer Breitling, SA Becker, SD Bentley, Stephen S. Fong, TD Vo, TY Kim, XQ Zhao   +59 more
core   +6 more sources

Flux networks in metabolic graphs [PDF]

, 2009
A metabolic model can be represented as bipartite graph comprising linked reaction and metabolite nodes. Here it is shown how a network of conserved fluxes can be assigned to the edges of such a graph by combining the reaction fluxes with a conserved ...
Dantzig G B, J L Jones, Jerrold J H, P B Warren, Palsson B Ø, Press W H, Reed J L, S M Duarte Queiros, Smith E B, Temkin O N   +9 more
core   +1 more source

MetExploreViz: web component for interactive metabolic network visualization [PDF]

, 2017
Summary: MetExploreViz is an open source web component that can be easily embedded in any web site. It provides features dedicated to the visualization of metabolic networks and pathways and thus offers a flexible solution to analyse omics data in a ...
Chazalviel, Maxime, Cottret, Ludovic, Frainay, Clément, Gloaguen, Yoann, Jourdan, Fabien, Merlet, Benjamin, Poupin, Nathalie, Vinson, Florence   +7 more
core   +4 more sources

An Entire Process Optimization Strategy for Comprehensive In Vivo Metabolite Profiling of Prucalopride in Rats Based on Ultra-Performance Liquid Chromatography With Q-Exactive Hybrid Quadrupole–Orbitrap High-Resolution Mass Spectrometry

Frontiers in Pharmacology, 2021
Prucalopride was widely used for chronic constipation, which is difficult to be adequately relieved by laxatives in adult patients in clinic. Due to the difficulty in metabolite identification, metabolic process of prucalopride had not been investigated ...
Lihua Zuo, Lihua Zuo, Liwei Liu, Liwei Liu, Yantao Yang, Yantao Yang, Jie Yang, Jie Yang, Min Chen, Huafeng Zhang, Jian Kang, Jian Kang, Xiaojian Zhang, Xiaojian Zhang, Jiabo Wang, Zhi Sun, Zhi Sun   +16 more
doaj   +1 more source

Microbial diversity and metabolic networks in acid mine drainage habitats

Frontiers in Microbiology, 2015
Acid mine drainage (AMD) emplacements are low-complexity natural systems. Low-pH conditions appear to be the main factor underlying the limited diversity of the microbial populations thriving in these environments, although temperature, ionic composition,
Celia eMendez-Garcia, Celia eMendez-Garcia, Ana Isabel Pelaez, Victoria eMesa, Jesús eSánchez, Olga V. Golyshina, Manuel eFerrer   +6 more
doaj   +1 more source

What mRNA Abundances Can Tell us about Metabolism

Metabolites, 2012
Inferring decreased or increased metabolic functions from transcript profiles is at first sight a bold and speculative attempt because of the functional layers in between: proteins, enzymatic activities, and reaction fluxes. However, the growing interest
Andreas Hoppe
doaj   +1 more source

Use of a global metabolic network to curate organismal metabolic networks [PDF]

Scientific Reports, 2013
The difficulty in annotating the vast amounts of biological information poses one of the greatest current challenges in biological research. The number of genomic, proteomic, and metabolomic datasets has increased dramatically over the last two decades, far outstripping the pace of curation efforts.
A. R. Pah, R. Guimerà, A. M. Mustoe, L. A. N. Amaral   +3 more
openaire   +2 more sources

Network Architecture and Mutational Sensitivity of the C. elegans Metabolome

Frontiers in Molecular Biosciences, 2018
A fundamental issue in evolutionary systems biology is understanding the relationship between the topological architecture of a biological network, such as a metabolic network, and the evolution of the network. The rate at which an element in a metabolic
Lindsay M. Johnson, Luke M. Chandler, Sarah K. Davies, Charles F. Baer, Charles F. Baer   +4 more
doaj   +1 more source

Periodic ethanol supply as a path toward unlimited lifespan of Caenorhabditis elegans dauer larvae

Frontiers in Aging, 2023
The dauer larva is a specialized stage of worm development optimized for survival under harsh conditions that have been used as a model for stress resistance, metabolic adaptations, and longevity.
Xingyu Zhang, Xingyu Zhang, Sider Penkov, Sider Penkov, Teymuras V. Kurzchalia, Vasily Zaburdaev, Vasily Zaburdaev   +6 more
doaj   +1 more source

Quantitative proteomic analysis reveals a simple strategy of global resource allocation in bacteria

Molecular Systems Biology, 2015
A central aim of cell biology was to understand the strategy of gene expression in response to the environment. Here, we study gene expression response to metabolic challenges in exponentially growing Escherichia coli using mass spectrometry.
Sheng Hui, Josh M Silverman, Stephen S Chen, David W Erickson, Markus Basan, Jilong Wang, Terence Hwa, James R Williamson   +7 more
doaj   +1 more source