Results 51 to 60 of about 898,161 (347)
Automation on the generation of genome scale metabolic models [PDF]
, 2012 Background: Nowadays, the reconstruction of genome scale metabolic models is a non-automatized and interactive process based on decision taking. This lengthy process usually requires a full year of one person's work in order to satisfactory collect ...
de Córdoba, P. Fernández +6 more
core +1 more source
FEBS Letters, EarlyView.Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
wiley +1 more source
Biomolecules, 2023 Background: Whole-genome models (GEMs) have become a versatile tool for systems biology, biotechnology, and medicine. GEMs created by automatic and semi-automatic approaches contain a lot of redundant reactions.
Anatoly Sorokin, Igor Goryanin
doaj +1 more source
Hypergraph models of metabolism [PDF]
, 2014 In this paper, we employ a directed hypergraph model to investigate the extent to which environmental variability influences the set of available biochemical reactions within a living cell.
Chuzhanova, N, Crofts, JJ, Pearcy, N
core
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Environmental and genetic perturbations reveal different networks of metabolic regulation
Molecular Systems Biology, 2011 Progress in systems biology depends on accurate descriptions of biological networks. Connections in a regulatory network are identified as correlations of gene expression across a set of environmental or genetic perturbations.
Anthony J Greenberg +3 more
doaj +1 more source
Multinuclear NMR spectroscopy and isotopomer distribution analysis applied to metabolic phenotype characterization of complex systems [PDF]
, 2014 In the present work, the complex metabolic effects of a rag8 genetic mutation performed on Kluyveromyces lactis yeast cells is investigated with a specific, ‘information-rich’ analytical approach: differential NMR metabolomics. The use of such NMR-based
GORIETTI, DANIELA
core
Detecting degree symmetries in networks [PDF]
, 2006 The surrounding of a vertex in a network can be more or less symmetric. We derive measures of a specific kind of symmetry of a vertex which we call degree symmetry -- the property that many paths going out from a vertex have overlapping degree sequences.
Petter Holme +4 more
core +2 more sources
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
The Genome-Scale Integrated Networks in Microorganisms
Frontiers in Microbiology, 2018 The genome-scale cellular network has become a necessary tool in the systematic analysis of microbes. In a cell, there are several layers (i.e., types) of the molecular networks, for example, genome-scale metabolic network (GMN), transcriptional ...
Tong Hao +7 more
doaj +1 more source