Results 101 to 110 of about 297,984 (312)

A Statistical Thermodynamical Interpretation of Metabolism

Entropy, 2010
The metabolic network of a cell can be decomposed into discrete elementary modes that contribute, each with a certain probability, to the overall flux through the metabolism.
Pornkamol Unrean, Friedrich Srienc
doaj   +1 more source

Neural Networks and Metabolic Networks: Fault Tolerance and Robustness Features [PDF]

, 2009
The main objective of this work is the comparison between metabolic networks and neural networks (ANNs) in terms of their robustness and fault tolerance capabilities.
CONTI, Vincenzo, SORBELLO, Filippo, Lanza, B., VITABILE, Salvatore   +3 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Visual analysis of multi-omics data

Frontiers in Bioinformatics
We present a tool for multi-omics data analysis that enables simultaneous visualization of up to four types of omics data on organism-scale metabolic network diagrams.
Austin Swart, Ron Caspi, Suzanne Paley, Peter D. Karp   +3 more
doaj   +1 more source

Kulcsfontosságú gének genomikai előrejelzése: In Silico megközelítés = Genomic prediction of essential genes: in silico approach [PDF]

, 2009
Kulcsfontosságú gének bioinformatikai elemzése: Csoportunk számos számos olyan sajátságot ismertek fel, melyek segítségével jellemezni lehet az esszenciális vagy a géndózis változására érzékeny géneket.
Pál, Csaba
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

FluxSimulator: An R Package to Simulate Isotopomer Distributions in Metabolic Networks [PDF]

The representation of biochemical knowledge in terms of fluxes (transformation rates) in a metabolic network is often a crucial step in the development of new drugs and efficient bioreactors.
Thomas W. Binsl, Ivo H. M. van Stokkum, Johannes H. G. M. van Beek, Jaap Heringa, Katharine M. Mullen   +4 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

How Does Nature Create the Painting “Gradient Coloration of ‘Manicure Finger’ Grape”? Integrated Omics Unveil the Pigments Basis and Metabolism Networks of Its Formation

Food Frontiers
‘Manicure Finger’ grape exhibits gradient coloration during veraison, where the lower part of the skin changes color faster and intenser than the upper, giving the same berry a gradient color from green on the top to red on the bottom.
Shihan Bao, Jianing Li, Jiaqi Wang, Tian Lan, Mengyuan Wei, Xiangyu Sun, Yulin Fang, Tingting Ma   +7 more
doaj   +1 more source

Adaptation of the Human Gut Microbiota Metabolic Network During the First Year After Birth

Frontiers in Microbiology, 2019
Predicting the metabolic behavior of the human gut microbiota in different contexts is one of the most promising areas of constraint-based modeling.
Alvaro Fuertes, Alvaro Fuertes, Sergio Pérez-Burillo, Iñigo Apaolaza, Iñigo Apaolaza, Yvonne Vallès, Yvonne Vallès, M. Pilar Francino, M. Pilar Francino, José Ángel Rufián-Henares, José Ángel Rufián-Henares, Francisco J. Planes, Francisco J. Planes   +12 more
doaj   +1 more source