Results 121 to 130 of about 282,038 (168)

Metabolic Network of Nucleosides in the Brain

Current Topics in Medicinal Chemistry, 2011
Brain relies on circulating nucleosides, mainly synthesised de novo in the liver, for the synthesis of nucleotides, RNA, nuclear and mitochondrial DNA, coenzymes, and pyrimidine sugar- and lipid-conjugates. Essentially, the paths of nucleoside salvage in the brain include a two step conversion of inosine and guanosine to IMP and GMP, respectively, and ...
Ipata PL, CAMICI, MARCELLA, Micheli V, TOZZI, MARIA GRAZIA   +3 more
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Modelling Metabolic Networks—The Theories of Metabolism

2013
Abstract There are several theoretical approaches to metabolism. Some of them give a greater place to the structure of the metabolic network symbolized by its stoichiometry matrix. The constraints in a metabolic network are very strong so that a lot of information can be derived from the stoichiometry matrix without any knowledge of the kinetic ...
Mazat, Jean-Pierre, Beauvoit, Bertrand
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Metabolic Networks

2009
World Scientific Lecture Notes in Complex ...
Maria Concetta Palumbo, Lorenzo Farina, Alfredo Colosimo, Alessandro Giuliani   +3 more
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Metabolic Networking

Science, 2012
A key design principle of bacterial metabolic networks is optimal performance, but not at the expense of adaptability.
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Metabolic Networks and Their Evolution

2012
Since the last decade of the twentieth century, systems biology has gained the ability to study the structure and function of genome-scale metabolic networks. These are systems of hundreds to thousands of chemical reactions that sustain life. Most of these reactions are catalyzed by enzymes which are encoded by genes.
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Profiling metabolic networks to study cancer metabolism

Current Opinion in Biotechnology, 2013
Cancer is a disease of unregulated cell growth and survival, and tumors reprogram biochemical pathways to aid these processes. New capabilities in the computational and bioanalytical characterization of metabolism have now emerged, facilitating the identification of unique metabolic dependencies that arise in specific cancers.
HILLER, Karsten, Metallo, Christian M.
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Differential metabolic and coexpression networks of plant metabolism

Trends in Plant Science, 2015
Recent analyses have demonstrated that plant metabolic networks do not differ in their structural properties and that genes involved in basic metabolic processes show smaller coexpression than genes involved in specialized metabolism. By contrast, our analysis reveals differences in the structure of plant metabolic networks and patterns of coexpression
Nooshin Omranian, Sabrina Kleessen, Takayuki Tohge, Sebastian Klie, Georg Basler, Bernd Mueller-Roeber, Alisdair R. Fernie, Zoran Nikoloski   +7 more
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Metabolic Networks: Beyond the Graph

Current Computer Aided-Drug Design, 2011
Drugs are devised to enter into the metabolism of an organism in order to produce a desired effect. From the chemical point of view, cellular metabolism is constituted by a complex network of reactions transforming metabolites one in each other. Knowledge on the structure of this network could help to develop novel methods for drug design, and to ...
Andrés, Bernal, Edgar, Daza
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Metabolic network sensitivity analysis

Journal of Theoretical Biology, 1982
Abstract A linear sensitivity analysis of metabolic regulation in nonsteady states is described. This treatment considers the effects of enzymatic and nonenzymatic reactions and spontaneous rapid equilibria. Sensitivity coefficients summarizing the influence of metabolite concentrations on reaction rates and pathway net flux are defined, as are ...
M C, Kohn, E, Chiang
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Genome‐scale metabolic networks

WIREs Systems Biology and Medicine, 2009
AbstractDuring the last decade, models have been developed to characterize cellular metabolism at the level of an entire metabolic network. The main concept that underlies whole‐network metabolic modeling is the identification and mathematical definition of constraints.
Terzer M, Maynard ND, Covert MW, Stelling J   +3 more
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