Results 111 to 120 of about 297,984 (312)
Systems approaches to modelling pathways and networks. [PDF]
, 2011 Peer ...
Christian, Nils +5 more
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Mathematical analysis of metabolic networks
FEBS Letters, 1974 Although its important reaction sequences and cycles have been known for more than 25 years, we are still far from a satisfactory theory of intermediary metabolism. The empirical material is overwhelming and increases every year, but the development of a general conception is still in its infancy, although the conceptual progress of recent years has ...
Reich, J.G., Sel'kov, E.E.
openaire +2 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Why excluding H2O from metabolic networks? [PDF]
, 2012 This study provides a novel perspective on the reason for excluding H2O from metabolic networks when complex network theory is ...
DeWu Ding
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Robustness of complex networks to node and cluster damage [PDF]
, 2009 Copyright @ 2009 Universtiy of WarwickThe goal of this investigation is to assess the robustness of two popular network structures – random networks and scale-free networks – to node and cluster damage. There is no previous work on the latter.
Al-Raweshidy, H, Atherton, MA, Gegov, E
core
Algebraic comparison of metabolic networks, phylogenetic inference, and metabolic innovation [PDF]
, 2006 Background Comparison of metabolic networks is typically performed based on the organisms' enzyme contents. This approach disregards functional replacements as well as orthologies that are misannotated.
Hofacker Ivo L +7 more
core +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source