Results 271 to 280 of about 297,984 (312)

Metabolic Networks and Their Evolution

2012
Since the last decade of the twentieth century, systems biology has gained the ability to study the structure and function of genome-scale metabolic networks. These are systems of hundreds to thousands of chemical reactions that sustain life. Most of these reactions are catalyzed by enzymes which are encoded by genes.
openaire   +4 more sources

Profiling metabolic networks to study cancer metabolism

Current Opinion in Biotechnology, 2013
Cancer is a disease of unregulated cell growth and survival, and tumors reprogram biochemical pathways to aid these processes. New capabilities in the computational and bioanalytical characterization of metabolism have now emerged, facilitating the identification of unique metabolic dependencies that arise in specific cancers.
HILLER, Karsten, Metallo, Christian M.
openaire   +3 more sources

VRML metabolic network visualizer

Computers in Biology and Medicine, 2003
A successful date collection visualization should satisfy a set of many requirements: unification of diverse data formats, support for serendipity research, support of hierarchical structures, algorithmizability, vast information density, Internet-readiness, and other.
Igor Rojdestvenski, Michael Cottam
openaire   +3 more sources

Differential metabolic and coexpression networks of plant metabolism

Trends in Plant Science, 2015
Recent analyses have demonstrated that plant metabolic networks do not differ in their structural properties and that genes involved in basic metabolic processes show smaller coexpression than genes involved in specialized metabolism. By contrast, our analysis reveals differences in the structure of plant metabolic networks and patterns of coexpression
Nooshin Omranian, Sabrina Kleessen, Takayuki Tohge, Sebastian Klie, Georg Basler, Bernd Mueller-Roeber, Alisdair R. Fernie, Zoran Nikoloski   +7 more
openaire   +4 more sources

Metabolic Networks: Beyond the Graph

Current Computer Aided-Drug Design, 2011
Drugs are devised to enter into the metabolism of an organism in order to produce a desired effect. From the chemical point of view, cellular metabolism is constituted by a complex network of reactions transforming metabolites one in each other. Knowledge on the structure of this network could help to develop novel methods for drug design, and to ...
Andrés, Bernal, Edgar, Daza
openaire   +2 more sources

Metabolic network sensitivity analysis

Journal of Theoretical Biology, 1982
Abstract A linear sensitivity analysis of metabolic regulation in nonsteady states is described. This treatment considers the effects of enzymatic and nonenzymatic reactions and spontaneous rapid equilibria. Sensitivity coefficients summarizing the influence of metabolite concentrations on reaction rates and pathway net flux are defined, as are ...
M C, Kohn, E, Chiang
openaire   +2 more sources

Genome‐scale metabolic networks

WIREs Systems Biology and Medicine, 2009
AbstractDuring the last decade, models have been developed to characterize cellular metabolism at the level of an entire metabolic network. The main concept that underlies whole‐network metabolic modeling is the identification and mathematical definition of constraints.
Terzer M, Maynard ND, Covert MW, Stelling J   +3 more
openaire   +3 more sources

Flux modules in metabolic networks

Journal of Mathematical Biology, 2013
The huge number of elementary flux modes in genome-scale metabolic networks makes analysis based on elementary flux modes intrinsically difficult. However, it has been shown that the elementary flux modes with optimal yield often contain highly redundant information. The set of optimal-yield elementary flux modes can be compressed using modules.
Müller, Arne C., Bockmayr, Alexander
openaire   +3 more sources

Network Analysis of Metabolic Networks

2013
Στη παρούσα διπλωματική εργασία επιχειρούμε μια εξονυχιστική εξέταση των μεταβολικών δικτύων και εξετάζουμε τη στατιστική τους συμπεριφορά. Κύριο εργαλείο σε αυτή μας την έρευνα είναι η θεωρία δικτύων. Έτσι, ξεκινάμε με μια όσο το δυνατό πιο πλήρη αναφορά στην παραπάνω θεωρία και τις ιδιότητες που την διακατέχουν. Έννοιες όπως μικρόκοσμος, κατανομή των
openaire   +1 more source

A source of stability in metabolic networks

Journal of Theoretical Biology, 1972
Abstract The generally observed monotonic dependence of enzyme activity on substrate concentration is utilized to give a plausible account of some aspects of the behavior of complex biochemical networks on the “metabolic” time scale. The adduced dynamical equations are shown to prescribe a “canalized” metabolic behavior, in which flow lines in state ...
openaire   +2 more sources