Results 1 to 10 of about 335,580 (367)
Metabolic pathways variability and sequence/networks comparisons [PDF]
BMC Bioinformatics, 2006 Abstract Background In this work a simple method for the computation of relative similarities between homologous metabolic network modules is presented. The method is similar to classical sequence alignment and allows for the generation of phenotypic trees amenable to be compared with correspondent sequence based ...
Pawan K. Dhar +3 more
doaj +7 more sources
Pathway Preserving Representation of Metabolic Networks [PDF]
Computer Graphics Forum, 2011 AbstractImprovements in biological data acquisition and genomes sequencing now allow to reconstruct entire metabolic networks of many living organisms. The size and complexity of these networks prohibit manual drawing and thereby urge the need of dedicated visualization techniques.
Lambert, Antoine +2 more
openaire +6 more sources
Estimation of the number of extreme pathways for metabolic networks [PDF]
BMC Bioinformatics, 2007 Abstract Background The set of extreme pathways (ExPa), {p i }, defines the convex basis vectors used for the mathematical characterization of the null space of the stoichiometric matrix for biochemical reaction networks.
Matthew Yeung +2 more
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Leveraging heterogeneous network embedding for metabolic pathway prediction [PDF]
Bioinformatics, 2020 AbstractMotivationMetabolic pathway reconstruction from genomic sequence information is a key step in predicting regulatory and functional potential of cells at the individual, population and community levels of organization. Although the most common methods for metabolic pathway reconstruction are gene-centric e.g.
Basher, Abdur Rahman M. A. +1 more
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Network structure of metabolic pathways [PDF]
Journal of Biological Physics and Chemistry, 2001 networks (or graphs) consist of nodes and links between them. The number of links per node, which we call the class of the node, may vary between nodes, but in a homogeneous network the statistical distribution of links will be the same from region to region across the network.
Vic Norris, Upres A Cnrs, Derek Raine
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Alterations in metabolic pathways and networks in Alzheimer’s disease [PDF]
Translational Psychiatry, 2013 The pathogenic mechanisms of Alzheimer's disease (AD) remain largely unknown and clinical trials have not demonstrated significant benefit. Biochemical characterization of AD and its prodromal phase may provide new diagnostic and therapeutic insights.
Rima Kaddurah-Daouk +15 more
openaire +4 more sources
Drawing oriented metabolic pathways and networks [PDF]
Tradicionalment, les vies metabòliques s'han representat manualment o semiautomàticament, un procés que sovint requereix molt de temps així com ajustaments manuals substancials.
Pérez Guerrero, Laura Hui
core +2 more sources
Pathway Tools Visualization of Organism-Scale Metabolic Networks [PDF]
Metabolites, 2021 Metabolomics, synthetic biology, and microbiome research demand information about organism-scale metabolic networks. The convergence of genome sequencing and computational inference of metabolic networks has enabled great progress toward satisfying that demand by generating metabolic reconstructions from the genomes of thousands of sequenced organisms.
Suzanne Paley +4 more
openaire +3 more sources
Pathways and fluxes: exploring the plant metabolic network [PDF]
Journal of Experimental Botany, 2012 The transition from a pathway-centred view of plant metabolism to a network-wide perspective is still incomplete. Further progress in this direction requires tools to facilitate the structural description of the network on the basis of fully annotated genomes, techniques for modelling the properties of the network, and experimental methods for ...
Kruger, N, Ratcliffe, R
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A statistical mechanics description of environmental variability in metabolic networks [PDF]
, 2014 Many of the chemical reactions that take place within a living cell are irreversible. Due to evolutionary pressures, the number of allowable reactions within these systems are highly constrained and thus the resulting metabolic networks display ...
A Cornish-Bowden +19 more
core +1 more source