Metabolic pathways variability and sequence/networks comparisons [PDF]
BMC Bioinformatics, 2006 Background In this work a simple method for the computation of relative similarities between homologous metabolic network modules is presented. The method is similar to classical sequence alignment and allows for the generation of phenotypic trees ...
Palumbo Maria +3 more
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Serum and urine metabolomic biomarkers for predicting prognosis in patients with immunoglobulin A nephropathy [PDF]
Kidney Research and Clinical Practice, 2023 Background Immunoglobulin A nephropathy (IgAN) is the most prevalent form of glomerulonephritis worldwide. Prediction of disease progression in IgAN can help to provide individualized treatment based on accurate risk stratification.
You Hyun Jeon +7 more
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Metabolomic approaches applied to the study of cervical cancer: a systematic review
Brazilian Journal of Oncology, 2022 Background: Cervical cancer (CC) is the fourth leading cause of cancer among women in the world. Metabolomics can provide a deeper understanding of the underlying metabolic alterations associated with its pathophysiology ...
Natalia Damasceno Almeida +3 more
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Integrated RNA-sequencing and network analysis approach to identify the Hub genes and vital pathways associated with gastric cancer [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2023 Context: Gastric cancer is one of the most prevalent types of cancer in developing countries and ranks fourth in terms of death causes. Helicobacter pylori infection is a significant contributor to the emergence of gastric cancer. Lack of early diagnosis
Karthick Vasudevan +12 more
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Finding branched pathways in metabolic network via atom group tracking.
PLoS Computational Biology, 2021 Finding non-standard or new metabolic pathways has important applications in metabolic engineering, synthetic biology and the analysis and reconstruction of metabolic networks.
Yiran Huang +3 more
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Metabolic network visualization eliminating node redundance and preserving metabolic pathways [PDF]
BMC Systems Biology, 2007 AbstractBackgroundThe tools that are available to draw and to manipulate the representations of metabolism are usually restricted to metabolic pathways. This limitation becomes problematic when studying processes that span several pathways. The various attempts that have been made to draw genome-scale metabolic networks are confronted with two ...
Bourqui, Romain +6 more
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Pathways and fluxes: exploring the plant metabolic network [PDF]
Journal of Experimental Botany, 2012 The transition from a pathway-centred view of plant metabolism to a network-wide perspective is still incomplete. Further progress in this direction requires tools to facilitate the structural description of the network on the basis of fully annotated genomes, techniques for modelling the properties of the network, and experimental methods for ...
Kruger, N, Ratcliffe, R
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A toolbox model of evolution of metabolic pathways on networks of arbitrary topology. [PDF]
PLoS Computational Biology, 2011 In prokaryotic genomes the number of transcriptional regulators is known to be proportional to the square of the total number of protein-coding genes.
Tin Yau Pang, Sergei Maslov
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Alterations in metabolic pathways and networks in Alzheimer’s disease [PDF]
Translational Psychiatry, 2013 The pathogenic mechanisms of Alzheimer's disease (AD) remain largely unknown and clinical trials have not demonstrated significant benefit. Biochemical characterization of AD and its prodromal phase may provide new diagnostic and therapeutic insights.
Kaddurah-Daouk, R. +14 more
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The global integrative network: integration of signaling and metabolic pathways
aBIOTECH, 2022 Abstract The crosstalk between signaling and metabolic pathways has been known to play key roles in human diseases and plant biological processes. The integration of signaling and metabolic pathways can provide an essential reference framework for crosstalk analysis.
Yuying Lin +4 more
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