Results 11 to 20 of about 363,947 (345)

Finding branched pathways in metabolic network via atom group tracking.

PLoS Computational Biology, 2021
Finding non-standard or new metabolic pathways has important applications in metabolic engineering, synthetic biology and the analysis and reconstruction of metabolic networks.
Yiran Huang, Yusi Xie, Cheng Zhong, Fengfeng Zhou   +3 more
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Metabolic network visualization eliminating node redundance and preserving metabolic pathways [PDF]

BMC Systems Biology, 2007
AbstractBackgroundThe tools that are available to draw and to manipulate the representations of metabolism are usually restricted to metabolic pathways. This limitation becomes problematic when studying processes that span several pathways. The various attempts that have been made to draw genome-scale metabolic networks are confronted with two ...
Bourqui, Romain, Cottret, L., Lacroix, Vincent, Auber, D., Mary, P., Sagot, M.-F., Jourdan, F.   +6 more
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Pathways and fluxes: exploring the plant metabolic network [PDF]

Journal of Experimental Botany, 2012
The transition from a pathway-centred view of plant metabolism to a network-wide perspective is still incomplete. Further progress in this direction requires tools to facilitate the structural description of the network on the basis of fully annotated genomes, techniques for modelling the properties of the network, and experimental methods for ...
Kruger, N, Ratcliffe, R
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A toolbox model of evolution of metabolic pathways on networks of arbitrary topology. [PDF]

PLoS Computational Biology, 2011
In prokaryotic genomes the number of transcriptional regulators is known to be proportional to the square of the total number of protein-coding genes.
Tin Yau Pang, Sergei Maslov
doaj   +1 more source

Alterations in metabolic pathways and networks in Alzheimer’s disease [PDF]

Translational Psychiatry, 2013
The pathogenic mechanisms of Alzheimer's disease (AD) remain largely unknown and clinical trials have not demonstrated significant benefit. Biochemical characterization of AD and its prodromal phase may provide new diagnostic and therapeutic insights.
Kaddurah-Daouk, R., Zhu, H., Sharma, S., Bogdanov, M., Rozen, S.G., Matson, W., Oki, N.O., Motsinger-Reif, A.A., Churchill, E., Lei, Z., Appleby, D., Kling, M.A., Trojanowski, J.Q., Doraiswamy, P.M., Arnold, S.E.   +14 more
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The global integrative network: integration of signaling and metabolic pathways

aBIOTECH, 2022
Abstract The crosstalk between signaling and metabolic pathways has been known to play key roles in human diseases and plant biological processes. The integration of signaling and metabolic pathways can provide an essential reference framework for crosstalk analysis.
Yuying Lin, Shen Yan, Xiao Chang, Xiaoquan Qi, Xu Chi   +4 more
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A Bioinformatics-Assisted Review on Iron Metabolism and Immune System to Identify Potential Biomarkers of Exercise Stress-Induced Immunosuppression

Biomedicines, 2022
The immune function is closely related to iron (Fe) homeostasis and allostasis. The aim of this bioinformatics-assisted review was twofold; (i) to update the current knowledge of Fe metabolism and its relationship to the immune system, and (ii) to ...
Diego A. Bonilla, Yurany Moreno, Jorge L. Petro, Diego A. Forero, Salvador Vargas-Molina, Adrián Odriozola-Martínez, Carlos A. Orozco, Jeffrey R. Stout, Eric S. Rawson, Richard B. Kreider   +9 more
doaj   +1 more source

Discriminating response groups in metabolic and regulatory pathway networks [PDF]

Bioinformatics, 2012
Abstract Motivation: Analysis of omics experiments generates lists of entities (genes, metabolites, etc.) selected based on specific behavior, such as changes in response to stress or other signals. Functional interpretation of these lists often uses category enrichment tests using functional annotations like Gene Ontology terms and ...
John L, Van Hemert, Julie A, Dickerson
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Inferring qualitative relations in genetic networks and metabolic pathways [PDF]

Bioinformatics, 2000
Abstract Motivation: Inferring genetic network architecture from time series data of gene expression patterns is an important topic in bioinformatics. Although inference algorithms based on the Boolean network were proposed, the Boolean network was not sufficient as a model of a genetic network.
T, Akutsu, S, Miyano, S, Kuhara
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Linking Metabolic QTLs with Network and cis-eQTLs Controlling Biosynthetic Pathways [PDF]

PLoS Genetics, 2007
Phenotypic variation between individuals of a species is often under quantitative genetic control. Genomic analysis of gene expression polymorphisms between individuals is rapidly gaining popularity as a way to query the underlying mechanistic causes of variation between individuals.
Wentzell, Adam M., Rowe, Heather C., Hansen, Bjarne Gram, Ticconi, Carla, Halkier, Barbara Ann, Kliebenstein, Daniel James   +5 more
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