Signatures of arithmetic simplicity in metabolic network architecture [PDF]
, 2010 Metabolic networks perform some of the most fundamental functions in living cells, including energy transduction and building block biosynthesis. While these are the best characterized networks in living systems, understanding their evolutionary history ...
A Hintze +65 more
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The large-scale organization of metabolic networks [PDF]
, 2000 In a cell or microorganism the processes that generate mass, energy, information transfer, and cell fate specification are seamlessly integrated through a complex network of various cellular constituents and reactions. However, despite the key role these
Albert, R. +4 more
core +3 more sources
The link between ferroptosis and airway inflammatory diseases: A novel target for treatment
Frontiers in Molecular Biosciences, 2022 Ferroptosis is an iron-dependent mode of cell death characterized by intracellular lipid peroxide accumulation and a redox reaction imbalance. Compared with other modes of cell death, ferroptosis has specific biological and morphological features.
Zhiwei Lin +5 more
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Benchmarking procedures for high-throughput context specific reconstruction algorithms
Frontiers in Physiology, 2016 Recent progress in high-throughput data acquisition has shifted the focus from data generation to processing and understanding of how to integrate collected information.
Maria ePires Pacheco +2 more
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Chemical Transformation Motifs - Modelling Pathways as Integer Hyperflows [PDF]
, 2017 We present an elaborate framework for formally modelling pathways in chemical reaction networks on a mechanistic level. Networks are modelled mathematically as directed multi-hypergraphs, with vertices corresponding to molecules and hyperedges to ...
Andersen, Jakob L. +3 more
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Pathways and fluxes: exploring the plant metabolic network [PDF]
Journal of Experimental Botany, 2012 The transition from a pathway-centred view of plant metabolism to a network-wide perspective is still incomplete. Further progress in this direction requires tools to facilitate the structural description of the network on the basis of fully annotated genomes, techniques for modelling the properties of the network, and experimental methods for ...
Kruger, N, Ratcliffe, R
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What do we learn from correlations of local and global network properties? [PDF]
, 2006 In complex networks a common task is to identify the most important or "central" nodes. There are several definitions, often called centrality measures, which often lead to different results.
Albert +42 more
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The Streptomyces coelicolor small ORF trpM stimulates growth and morphological development and exerts opposite effects on actinorhodin and calcium-dependent antibiotic production [PDF]
, 2020 In actinomycetes, antibiotic production is often associated with a morpho-physiological differentiation program that is regulated by complex molecular and metabolic networks. Many aspects of these regulatory circuits have been already elucidated and many
Alberto Vassallo +7 more
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Inferring branching pathways in genome-scale metabolic networks [PDF]
BMC Systems Biology, 2009 A central problem in computational metabolic modelling is how to find biochemically plausible pathways between metabolites in a metabolic network. Two general, complementary frameworks have been utilized to find metabolic pathways: constraint-based modelling and graph-theoretical path finding approaches.
Paula Jouhten, Esa Pitkänen, Juho Rousu
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Role of Ferroptosis in Lung Diseases
Journal of Inflammation Research, 2021 Wenting Xu,1,2,* Huimin Deng,2,* Song Hu,2,3,* Yiguo Zhang,2,3 Li Zheng,1,2 Meiyun Liu,2 Yuanli Chen,2 Juan Wei,2 Hao Yang,2 Xin Lv1– 3 1Department of Anesthesiology, Fuyang Hospital of Anhui Medical University, Fuyang, Anhui, 236000, People&rsquo ...
Xu W +9 more
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