Results 31 to 40 of about 345,747 (340)

Peritoneal dialysis influences microRNA expression and pro-inflammatory response: results from a cross-sectional study [PDF]

Brazilian Journal of Nephrology
Introduction: The investigation of circulating microRNAs (miRNAs) and inflammatory response associated with the different stages of chronic kidney disease (CKD) may reveal biomarkers of disease pathogenesis. Our goal was to identifying differences in the
Nara Aline Costa, Amanda Gomes Pereira, Hellen Christina Neves Rodrigues, Lilian Cuppari, Tainara Francini Felix, Iael Weissberg Minutentag, Patricia Pintor Reis, André Luis Balbi, Bertha Furlan Polegato, Paula Schmidt Azevedo, Leonardo Antonio Mamede Zornoff, Sérgio Alberto Rupp de Paiva, Daniela Ponce, Marcelo Macedo Rogero, Marcos Ferreira Minicucci   +14 more
doaj   +1 more source

Metabolic Reprogramming in Triple-Negative Breast Cancer

Frontiers in Oncology, 2020
Metabolic reprogramming is an emerging hallmark of cancer cells, in which cancer cells exhibit distinct metabolic phenotypes to fuel their proliferation and progression.
Xiangyu Sun, Mozhi Wang, Mengshen Wang, Xueting Yu, Jingyi Guo, Tie Sun, Xinyan Li, Litong Yao, Haoran Dong, Yingying Xu   +9 more
doaj   +1 more source

Beyond the Biosynthetic Gene Cluster Paradigm: Genome-Wide Coexpression Networks Connect Clustered and Unclustered Transcription Factors to Secondary Metabolic Pathways

Microbiology Spectrum, 2021
Fungal secondary metabolites are widely used as therapeutics and are vital components of drug discovery programs. A major challenge hindering discovery of novel secondary metabolites is that the underlying pathways involved in their biosynthesis are ...
Min Jin Kwon, Charlotte Steiniger, Timothy C. Cairns, Jennifer H. Wisecaver, Abigail L. Lind, Carsten Pohl, Carmen Regner, Antonis Rokas, Vera Meyer   +8 more
doaj   +1 more source

MetExploreViz: web component for interactive metabolic network visualization [PDF]

, 2017
Summary: MetExploreViz is an open source web component that can be easily embedded in any web site. It provides features dedicated to the visualization of metabolic networks and pathways and thus offers a flexible solution to analyse omics data in a ...
Chazalviel, Maxime, Cottret, Ludovic, Frainay, Clément, Gloaguen, Yoann, Jourdan, Fabien, Merlet, Benjamin, Poupin, Nathalie, Vinson, Florence   +7 more
core   +3 more sources

Pathway discovery in metabolic networks by subgraph extraction

Bioinformatics, 2010
Abstract Motivation: Subgraph extraction is a powerful technique to predict pathways from biological networks and a set of query items (e.g. genes, proteins, compounds, etc.). It can be applied to a variety of different data types, such as gene expression, protein levels, operons or phylogenetic profiles.
Faust, Karoline, Dupont, Pierre, Callut, Jérôme, van Helden, Jacques   +3 more
openaire   +4 more sources

Metabolic network visualization eliminating node redundance and preserving metabolic pathways [PDF]

BMC Systems Biology, 2007
AbstractBackgroundThe tools that are available to draw and to manipulate the representations of metabolism are usually restricted to metabolic pathways. This limitation becomes problematic when studying processes that span several pathways. The various attempts that have been made to draw genome-scale metabolic networks are confronted with two ...
Bourqui, Romain, Cottret, L., Lacroix, Vincent, Auber, D., Mary, P., Sagot, M.-F., Jourdan, F.   +6 more
openaire   +4 more sources

Functional prediction of environmental variables using metabolic networks

Scientific Reports, 2021
In this manuscript, we propose a novel approach to assess relationships between environment and metabolic networks. We used a comprehensive dataset of more than 5000 prokaryotic species from which we derived the metabolic networks.
Adèle Weber Zendrera, Nataliya Sokolovska, Hédi A. Soula   +2 more
doaj   +1 more source

Alterations in cellular metabolism under different grades of glioma staging identified based on a multi-omics analysis strategy

Frontiers in Endocrinology, 2023
Glioma is a type of brain tumor closely related to abnormal cell metabolism. Firstly, multiple combinatorial sequencing studies have revealed this relationship.
Xianlei Yan, Xianlei Yan, Jinwei Li, Yang Zhang, Cong Liang, Pengcheng Liang, Tao Li, Quan Liu, Xuhui Hui   +8 more
doaj   +1 more source

A statistical mechanics description of environmental variability in metabolic networks [PDF]

, 2014
Many of the chemical reactions that take place within a living cell are irreversible. Due to evolutionary pressures, the number of allowable reactions within these systems are highly constrained and thus the resulting metabolic networks display ...
A Cornish-Bowden, A Cornish-Bowden, A Kreimer, E Estrada, E Estrada, E Estrada, Ernesto Estrada, HW Ma, J Peña De la, J Xu, Jonathan J. Crofts, M Arita, M Buchanan, M Kanehisa, M Parter, P Holme, R Guimerá, R Montañez, V Lacroix, V Párez-Brocal   +19 more
core   +1 more source

Metabolic PathFinding: inferring relevant pathways in biochemical networks [PDF]

Nucleic Acids Research, 2005
Our knowledge of metabolism can be represented as a network comprising several thousands of nodes (compounds and reactions). Several groups applied graph theory to analyse the topological properties of this network and to infer metabolic pathways by path finding.
Croes, Didier, Couche, Fabian, Wodak, Shoshana, van Helden, Jacques   +3 more
openaire   +5 more sources