Results 31 to 40 of about 335,580 (367)

Genome-scale metabolic modelling identifies reactions mediated by SNP-SNP interactions associated with yeast sporulation. [PDF]

NPJ Syst Biol Appl
Genome-scale metabolic models (GEMs) are powerful tools used to understand the functional effects of genetic variants. However, the impact of single nucleotide polymorphisms (SNPs) in transcription factors and their interactions on metabolic fluxes ...
Sasikumar S, Kumar SP, Bhatt NP, Sinha H.   +3 more
europepmc   +2 more sources

A Global Coexpression Network Approach for Connecting Genes to Specialized Metabolic Pathways in Plants

The Plant Cell, 2017
Jennifer H. Wisecaver, Alexander T. Borowsky, V. Tzin, G. Jander, D. Kliebenstein, A. Rokas   +5 more
semanticscholar   +2 more sources

Metabolomic approaches applied to the study of cervical cancer: a systematic review

Brazilian Journal of Oncology, 2022
Background: Cervical cancer (CC) is the fourth leading cause of cancer among women in the world. Metabolomics can provide a deeper understanding of the underlying metabolic alterations associated with its pathophysiology ...
Natalia Damasceno Almeida, Marcos Almeida Matos, Milena Bastos Brito, Amancio Jose de Souza   +3 more
doaj   +1 more source

Integrated RNA-sequencing and network analysis approach to identify the Hub genes and vital pathways associated with gastric cancer [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2023
Context: Gastric cancer is one of the most prevalent types of cancer in developing countries and ranks fourth in terms of death causes. Helicobacter pylori infection is a significant contributor to the emergence of gastric cancer. Lack of early diagnosis
Karthick Vasudevan, Raghavendra B, Mithun A, Dhanushkumar T, Fazil Ahmad, Manoj Goyal, Monika Bansal, Tasneem Mohammed, Riyaz Ahmed Khan, Gayathri Pandurangam, George Priya Doss, Balu Kamaraj, Gurudeeban Selvaraj   +12 more
doaj   +1 more source

Finding branched pathways in metabolic network via atom group tracking.

PLoS Computational Biology, 2021
Finding non-standard or new metabolic pathways has important applications in metabolic engineering, synthetic biology and the analysis and reconstruction of metabolic networks.
Yiran Huang, Yusi Xie, Cheng Zhong, Fengfeng Zhou   +3 more
doaj   +1 more source

Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and transcriptomic study

PLoS Medicine, 2020
Background There is growing evidence that Alzheimer disease (AD) is a pervasive metabolic disorder with dysregulation in multiple biochemical pathways underlying its pathogenesis.
Uma V. Mahajan, V. Varma, M. Griswold, C. Blackshear, Y. An, Anup M Oommen, S. Varma, J. Troncoso, O. Pletnikova, Richard O'Brien, T. Hohman, C. Legido-Quigley, M. Thambisetty   +12 more
semanticscholar   +1 more source

NICEpath: Finding metabolic pathways in large networks through atom-conserving substrate–product pairs

bioRxiv, 2020
Finding biosynthetic pathways is essential for metabolic engineering of organisms to produce chemicals, biodegradation prediction of pollutants and drugs, and for the elucidation of bioproduction pathways of secondary metabolites.
Jasmin Hafner, V. Hatzimanikatis
semanticscholar   +1 more source

Clustering analysis of tumor metabolic networks

BMC Bioinformatics, 2020
Background Biological networks are representative of the diverse molecular interactions that occur within cells. Some of the commonly studied biological networks are modeled through protein-protein interactions, gene regulatory, and metabolic pathways ...
Ichcha Manipur, Ilaria Granata, Lucia Maddalena, Mario R. Guarracino   +3 more
doaj   +1 more source

A Bioinformatics-Assisted Review on Iron Metabolism and Immune System to Identify Potential Biomarkers of Exercise Stress-Induced Immunosuppression

Biomedicines, 2022
The immune function is closely related to iron (Fe) homeostasis and allostasis. The aim of this bioinformatics-assisted review was twofold; (i) to update the current knowledge of Fe metabolism and its relationship to the immune system, and (ii) to ...
Diego A. Bonilla, Yurany Moreno, Jorge L. Petro, Diego A. Forero, Salvador Vargas-Molina, Adrián Odriozola-Martínez, Carlos A. Orozco, Jeffrey R. Stout, Eric S. Rawson, Richard B. Kreider   +9 more
doaj   +1 more source

MetNet: A two-level approach to reconstructing and comparing metabolic networks.

PLoS ONE, 2021
Metabolic pathway comparison and interaction between different species can detect important information for drug engineering and medical science. In the literature, proposals for reconstructing and comparing metabolic networks present two main problems ...
Nicoletta Cocco, Mercè Llabrés, Mariana Reyes-Prieto, Marta Simeoni   +3 more
doaj   +1 more source