Results 91 to 100 of about 1,447,822 (302)
Molecules, 2018 The present study aims for the first time to provide the in vivo acute toxicological profile of the highest dose of Clinacanthus nutans (Burm. f.) Lindau water leaf extract according to the Organization for economic co-operation and development (OECD ...
Leng Wei Khoo +7 more
doaj +1 more source
Pathway analysis of NAD+ metabolism [PDF]
Biochemical Journal, 2011 NAD+ is well known as a crucial cofactor in the redox balance of metabolism. Moreover, NAD+ is degraded in ADP-ribosyl transfer reactions, which are important components of multitudinous signalling reactions. These include reactions linked to DNA repair and aging.
de Figueiredo, Luis F. +3 more
openaire +3 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Essential plasticity and redundancy of metabolism unveiled by synthetic lethality analysis
, 2014 We unravel how functional plasticity and redundancy are essential mechanisms underlying the ability to survive of metabolic networks. We perform an exhaustive computational screening of synthetic lethal reaction pairs in Escherichia coli in a minimal ...
Güell, Oriol +2 more
core +3 more sources
Minimizing acetate formation in E. coli fermentations [PDF]
, 2007 Escherichia coli remains the best established production organisms in industrial biotechnology. However, during aerobic fermentation runs at high growth rates, considerable amounts of acetate are accumulated as by-product.
De Maeseneire, Sofie +3 more
core +2 more sources
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Pathway Tools version 23.0: Integrated Software for Pathway/Genome Informatics and Systems Biology
, 2019 Pathway Tools is a bioinformatics software environment with a broad set of capabilities. The software provides genome-informatics tools such as a genome browser, sequence alignments, a genome-variant analyzer, and comparative-genomics operations.
Billington, Richard +9 more
core
Sensitivity analysis and experimental design of a stiff signal transduction pathway model [PDF]
, 2007 Sensitivity analysis is normally used to analyze how sensitive a system is with respect to the change of parameters or initial conditions and is perhaps best known in systems biology via the formalism of metabolic control analysis [1, 2].
Brown, M. +4 more
core
Assessing the significance of knockout cascades in metabolic networks
, 2012 Complex networks have been shown to be robust against random structural perturbations, but vulnerable against targeted attacks. Robustness analysis usually simulates the removal of individual or sets of nodes, followed by the assessment of the inflicted ...
Basler, Georg +4 more
core +1 more source
Analysis of In Vitro Mirtazapine Metabolites in Human Liver Microsomes by LC-HRMS
Fayixue ZazhiObjectiveTo establish and optimize an in vitro incubation system with human liver microsomes and investigate the in vitro metabolites and possible metabolic pathways of mirtazapine.MethodsThree major metabolites of mirtazapine were selected to optimize ...
ZHANG Ying +5 more
doaj +1 more source