Results 101 to 110 of about 1,447,822 (302)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

The interplay between obesity and cancer: a fly view [PDF]

, 2016
Accumulating epidemiological evidence indicates a strong clinical association between obesity and an increased risk of cancer. The global pandemic of obesity indicates a public health trend towards a substantial increase in cancer incidence and mortality.
Hirabayashi, S
core   +2 more sources

Violet Phosphorene Nanosheets Induced the Death of Ovarian Cancer Cells by Modulating the Vitamin B6 Pathway

Molecules
Cancer remains a significant global public health concern. Numerous challenges still remain in its treatment. Recently, a novel two-dimensional material—violet phosphorene nanosheets (VPNS)—has shown considerable application potential in the biomedical ...
Xinyi Zhao, Yujing Xu, Zhengyi Liu, Shiling Dai, Miao Qi, Huaiyan Zhang, Jinying Zhang, Dehui Xu   +7 more
doaj   +1 more source

Databases of metabolic pathways [PDF]

Biochemistry and Molecular Biology Education, 2006
AbstractStudies of metabolism usually evoke memories of densely written wall charts of metabolic pathways of enormous complexity, such as the IUBMB‐Nicholson metabolic pathways map or the Roche metabolic pathways wall chart. Advances in bioinformatics in the past decade have brought about a revolution in the way the information in metabolic pathways is
openaire   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Complex networks theory for analyzing metabolic networks

, 2006
One of the main tasks of post-genomic informatics is to systematically investigate all molecules and their interactions within a living cell so as to understand how these molecules and the interactions between them relate to the function of the organism,
A. B. Horne, A. Bairoch, A. Broder, A. L. Barabasi, A. L. Barabasi, A. Samal, A. Wagner, B. M. Bakker, C. H. Schilling, C. Wagner, D. J. Watts, E. Ravasz, H. Jeong, H. Kitano, H. Lipson, H. W. Ma, H. W. Ma, H. W. Ma, Hong Yu, J. A. Papin, J. C. M. Mombach, J. Gagneur, J. Stelling, J. Stelling, Jianhua Luo, Jing Zhao, L. H. Hartwell, M. Arita, M. C. Palumbo, M. Faloutsos, M. Kanehisa, M. Kanehisa, M. Nakao, M. V. Martinov, N. Lemke, P. D. Karp, P. D. Karp, P. Erdös, P. Holme, R. Albert, R. Guimera, R. Mahadevan, R. Overbeek, R. Schuster, S. Goto, S. Schuster, S. Schuster, S. Wuchty, Yixue Li, Z. N. Oltvai, Z. W. Cao   +50 more
core   +1 more source

Comparative Genome Analysis of Piscine Vibrio vulnificus: Virulence-Associated Metabolic Pathways

Microorganisms
Vibriosis caused by Vibrio vulnificus is a major problem in aquatic animals, particularly brown marble groupers (Epinephelus fuscoguttatus). V. vulnificus biotype I has recently been isolated and classified into subgroups SUKU_G1, SUKU_G2, and SUKU_G3 ...
Thararat Phurahong, Patcharee Soonson, Jumroensri Thawonsuwan, Varin Tanasomwang, Nontawith Areechon, Teerasak E-kobon, Sasimanas Unajak   +6 more
doaj   +1 more source

Restoring a Metabolic Pathway [PDF]

ACS Chemical Biology, 2008
Gluconeogenesis is blocked in a strain of Escherichia coli that is deficient in triosephosphate isomerase, but it was restored by the insertion of a plasmid coding for an L-glyceraldehyde 3-phosphate reductase (YghZ). This reductase provides a "bypass" that produces dihydroxyacetone phosphate (DHAP) by the consecutive enzyme-catalyzed reduction of L ...
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source