Results 101 to 110 of about 972,456 (315)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Metabolic engineering of Corynebacterium glutamicum aimed at alternative carbon sources and new products

, 2012
Zahoor ul Hassan A, Lindner S, Wendisch VF. Metabolic engineering of Corynebacterium glutamicum aimed at alternative carbon sources and new products. Computational and Structural Biotechnology Journal.
Wendisch, Volker F., Volker F. Wendisch, Wendisch, Volker F. ; https://orcid.org/, Zahoor, Ahmed, Steffen N. Lindner, Zahoor ul Hassan, Ahmed, Lindner, Steffen N., Lindner, Steffen, Ahmed Zahoor   +8 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Metabolomic analysis of Grifola frondosa mycelium in different culture periods

Guangxi Zhiwu
To gain a comprehensive understanding of the metabolite differences and metabolic pathways involved in the mycelium of Grifola frondosa during various culture periods, this study employed HPLC-MS/MS analysis to thoroughly investigate the mycelium ...
LIU Jinrong1,2, ZHANG Yancheng2, LIU Yan2, ZHANG Qiang3, LV Huqiang3,4, MOU Guangfu2*
doaj   +1 more source

Linking Genotype and Phenotype of Saccharomyces cerevisiae Strains Reveals Metabolic Engineering Targets and Leads to Triterpene Hyper-Producers [PDF]

, 2011
Background: Metabolic engineering is an attractive approach in order to improve the microbial production of drugs. Triterpenes is a chemically diverse class of compounds and many among them are of interest from a human health perspective.
Otero, Jose M., Otero, JM, Koetter, P, Jens Nielsen, Semba, Saori, Tetsuo Kushiro, Karina M Madsen, Nielsen, Jens B, Ebizuka, Yutaka, Jose M. Otero, Kötter, Peter, Gupta D. B. R. K. Udatha, Udatha, Gupta D. B. R. K., Semba, S, Yutaka Ebizuka, Otero Jose M., Jose M Otero, Nielsen, Jens, Panagiotou, Gianni, Panagiotou Gianni, Nielsen, J, Panagiotou, G, Gianni Panagiotou, Madsen Karina M., Udatha Gupta D. B. R. K., Semba Saori, Udatha, Gupta, Madsen, KM, Ebizuka, Y, Madsen, Karina Marie, Madsen, Karina M., Karina M. Madsen, Saori Semba, Udatha, GDBRK, Koetter Peter, Otero, Jos\ue9 Manuel, Otero Romero, José Manuel, Kushiro Tetsuo, Gupta D B R K Udatha, Ebizuka Yutaka, Kushiro, Tetsuo, Koetter, Peter, Kushiro, T, Udatha, D.B.R.K. Gupta, Nielsen Jens, Nielsen, Jens B., Peter Koetter   +46 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Investigating bacterial diversity involved in the production of vegetable-based ethnic fermented food of North Bengal and their metabolic pathways with reverse ecology approach

Frontiers in Sustainable Food Systems
Endemic fermented vegetables play a crucial role in local cuisine and culture, with traditionally fermented raw green vegetables such as gundruk being a popular practice in North Bengal and Sikkim, India.
Kriti Ghatani, Shankar Prasad Sha, Subarna Thapa, Indrani Sarkar, Indrani Sarkar, Gargi Sen, Arnab Sen   +6 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Reconstruction of an in silico metabolic model of _Arabidopsis thaliana_ through database integration

, 2009
The number of genome-scale metabolic models has been rising quickly in recent years, and the scope of their utilization encompasses a broad range of applications from metabolic engineering to biological discovery.
Karin Radrich, Albert Gevorgyan, Yoshimasa Tsuruoka, Jean-Marc Schwartz, Neil Swainston, Paul Dobson   +5 more
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