Results 81 to 90 of about 1,386,772 (353)

Representing and analysing molecular and cellular function in the computer [PDF]

, 2000
Determining the biological function of a myriad of genes, and understanding how they interact to yield a living cell, is the major challenge of the post genome-sequencing era.
Eldridge, M, Gilbert, D, Helden, JV, Mancuso, R, Naim, A, Wernisch, L, Wodak, SJ   +6 more
core   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

FLIM-MAP: Gene Context Based Identification of Functional Modules in Bacterial Metabolic Pathways

Frontiers in Microbiology, 2018
Prediction of functional potential of bacteria can only be ascertained by the accurate annotation of its metabolic pathways. Homology based methods decipher metabolic gene content but ignore the fact that homologs of same protein can function in ...
Vineet Bhatt, Anwesha Mohapatra, Swadha Anand, Bhusan K. Kuntal, Bhusan K. Kuntal, Sharmila S. Mande   +5 more
doaj   +1 more source

Effects of Fermentation Period on the Non-Volatile Metabolites of Chinese Ultra-Long-Term Solid Fermented Kohlrabi Based on Non-Targeted Metabolomic Analysis

Fermentation, 2023
This study aimed to investigate the effects of ultra-long-term fermentation on the formation of non-volatile metabolites of Chinese solid-fermented kohlrabies.
Xiaohan Jia, Hongfan Chen, Xinyi Wang, Xin Nie, Lu Xiang, Dayu Liu, Zhiping Zhao   +6 more
doaj   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Metabolic analyses elucidate nontrivial gene targets for amplifying dihydroartemisinic acid production in yeast

Frontiers in Microbiology, 2013
Synthetic biology enables metabolic engineering of industrial microbes to synthesize value-added molecules. In this, a major challenge is the efficient redirection of carbon to the desired metabolic pathways.
Ashish eMisra, Matthew F. Conway, Joseph eJohnnie, Tabish M. Qureshi, Anne M. Derrick, Eddy C. Agbo, Ganesh eSriram   +6 more
doaj   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

The Algicidal Fungus Trametes versicolor F21a Eliminating Blue Algae via Genes Encoding Degradation Enzymes and Metabolic Pathways Revealed by Transcriptomic Analysis

Frontiers in Microbiology, 2018
The molecular mechanism underlying the elimination of algal cells by fungal mycelia has not been fully understood. Here, we applied transcriptomic analysis to investigate the gene expression and regulation at time courses of Trametes versicolor F21a ...
Wei Dai, Xiaolin Chen, Xuewen Wang, Zimu Xu, Xueyan Gao, Chaosheng Jiang, Ruining Deng, Guomin Han, Guomin Han   +8 more
doaj   +1 more source

Computing the shortest elementary flux modes in genome-scale metabolic networks [PDF]

, 2009
This article is available open access through the publisher’s website through the link below. Copyright @ The Author 2009.Motivation: Elementary flux modes (EFMs) represent a key concept to analyze metabolic networks from a pathway-oriented perspective ...
Acuña, Adam Podhorski, Angel Rubio, Beasley, Blattner, Christoph Kaleta, Cohen, Dandekar, de Graaf, Eggeling, Eggeling, Feist, Fell, Fischer, Francisco J. Planes, Gagneur, Inui, John E. Beasley, Kacser, Kaleta, Kalinowski, Kjeldsen, Klamt, Klamt, Klamt, Koch, Liao, Luis F. de Figueiredo, Mavrovouniotis, Meléndez-Hevia, Molin, Niederberger, Pardalos, Pfeiffer, Planes, Price, Schilling, Schuster, Schuster, Schuster, Schuster, Schuster, Schwarz, Stefan Schuster, Subedi, Terzer, Teusink, Tosaka, Trinh, Vallino, van Winden, von Kamp, Wendisch, Wittmann, Yuan   +54 more
core   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source