Results 81 to 90 of about 4,047,137 (345)

Metabonomics Study in Mice With Learning and Memory Impairment on the Intervention of Essential Oil Extracted From Cinnamomum camphora Chvar. Borneol

Frontiers in Pharmacology, 2022
Our objective was to explore the mechanism of essential oil that was extracted from Cinnamomum camphora chvar. Borneol (Borneol essential oil) for improving learning and memory impairment in mice.
Yin Tang, Xiaofan Lv, Yumin Liu, Donghong Cui, Yani Wu   +4 more
doaj   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Construction of a synthetic metabolic pathway for biosynthesis of the non-natural methionine precursor 2,4-dihydroxybutyric acid

Nature Communications, 2017
2,4-Dihydroxybutyric acid (DHB) is a molecule with considerable potential as a versatile chemical synthon. Notably, it may serve as a precursor for chemical synthesis of the methionine analogue 2-hydroxy-4-(methylthio)butyrate, thus, targeting a ...
T. Walther, C. Topham, Romain Irague, C. Auriol, Audrey Baylac, Hélène Cordier, Clémentine Dressaire, Luce Lozano-Huguet, N. Tarrat, Nelly Martineau, Marion Stodel, Yannick Malbert, M. Maestracci, Robert Huet, I. André, M. Remaud-Siméon, J. François   +16 more
semanticscholar   +1 more source

Pattern of Protein Expression in Developing Wheat Grains Identified through Proteomic Analysis

Frontiers in Plant Science, 2017
Grain development is one of the biological processes, which contributes to the final grain yield. To understand the molecular changes taking place during the early grain development, we profiled proteomes of two common wheat cultivars P271 and Chinese ...
Mingming Yang, Mingming Yang, Xiang Gao, Xiang Gao, Jian Dong, Jian Dong, Nitant Gandhi, Huanjie Cai, Huanjie Cai, Diter H. von Wettstein, Sachin Rustgi, Sachin Rustgi, Shanshan Wen   +12 more
doaj   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source

A Novel Strategy for Efficient Agaro-Oligosaccharide Production Based on the Enzymatic Degradation of Crude Agarose in Flammeovirga pacifica WPAGA1

Frontiers in Microbiology, 2019
To avoid conflict between biofuel and food resource production, marine macroalgae (main algal polysaccharides) have been suggested as potent feedstock for biofuel production.
Boliang Gao, Boliang Gao, Li Li, Hui Wu, Du Zhu, Min Jin, Wu Qu, Runying Zeng, Runying Zeng   +8 more
doaj   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Alteration of Metabolic Pathways in Osteoarthritis [PDF]

Metabolites, 2019
Sir Archibald Edward Garrod, who pioneered the field of inborn errors of metabolism and first elucidated the biochemical basis of alkaptonuria over 100 years ago, suggested that inborn errors of metabolism were “merely extreme examples of variations of chemical behavior which are probably everywhere present in minor degrees, just as no two individuals ...
openaire   +4 more sources

A metabolic pathway for catabolizing levulinic acid in bacteria

Nature Microbiology, 2017
Microorganisms can catabolize a wide range of organic compounds and therefore have the potential to perform many industrially relevant bioconversions. One barrier to realizing the potential of biorefining strategies lies in our incomplete knowledge of ...
Jacqueline M. Rand, T. Pisithkul, Ryan L. Clark, Joshua M. Thiede, Christopher R. Mehrer, Daniel E. Agnew, C. Campbell, Andrew L. Markley, M. Price, J. Ray, Kelly M. Wetmore, Yumi Suh, A. Arkin, A. Deutschbauer, D. Amador-Noguez, Brian F. Pfleger   +15 more
semanticscholar   +1 more source