Results 41 to 50 of about 1,443,560 (303)

Fructose, insulin resistance, and metabolic dyslipidemia [PDF]

Nutrition & Metabolism, 2005
Abstract Obesity and type 2 diabetes are occurring at epidemic rates in the United States and many parts of the world. The "obesity epidemic" appears to have emerged largely from changes in our diet and reduced physical activity. An important but not well-appreciated dietary change has been the substantial increase in the amount of dietary ...
Basciano, Heather, Federico, Lisa, Adeli, Khosrow   +2 more
openaire   +4 more sources

Candidate Genes Involved in Tolerance to Fenoxaprop-P-Ethyl in Rice Induced by Isoxadifen-Ethyl Hydrolysate

Agronomy, 2023
The metabolic resistance of plants to herbicides is similar to the herbicide metabolism process accelerated by safeners. The tolerance to fenoxaprop-P-ethyl (FE) is distinct among different varieties of rice in which phytotoxicity forms easily, resulting
Yaning Zhao, Wenqing Li, Lanlan Sun, Renhai Wu, Hongle Xu, Wangcang Su, Chuantao Lu   +6 more
doaj   +1 more source

Impact of amoxicillin-clavulanate followed by autologous fecal microbiota transplantation on fecal microbiome structure and metabolic potential [PDF]

, 2018
The spread of multidrug resistance among pathogenic organisms threatens the efficacy of antimicrobial treatment options. The human gut serves as a reservoir for many drug-resistant organisms and their resistance genes, and perturbation of the gut ...
Bulow, Christopher, Burnham, Carey-Ann D, CDC Prevention Epicenter Program,, Dantas, Gautam, Dubberke, Erik R, Hink, Tiffany, Jones, Susan, Kwon, Jennie H, Langdon, Amy, Patel, Sanket, Reske, Kimberly A, Seiler, Sondra, Sun, Xiaoqing, Wallace, Meghan   +13 more
core   +2 more sources

Metabolic vulnerability of cisplatin‐resistant cancers [PDF]

The EMBO Journal, 2018
Cisplatin is the most widely used chemotherapeutic agent, and resistance of neoplastic cells against this cytoxicant poses a major problem in clinical oncology. Here, we explored potential metabolic vulnerabilities of cisplatin-resistant non-small human cell lung cancer and ovarian cancer cell lines.
Florine Obrist, Judith Michels, Sylvere Durand, Alexis Chery, Jonathan Pol, Sarah Levesque, Adrien Joseph, Valentina Astesana, Federico Pietrocola, Gen Sheng Wu, Maria Castedo, Guido Kroemer   +11 more
openaire   +2 more sources

Truncation of POC1A associated with short stature and extreme insulin resistance [PDF]

, 2015
We describe a female proband with primordial dwarfism, skeletal dysplasia, facial dysmorphism, extreme dyslipidaemic insulin resistance and fatty liver associated with a novel homozygous frameshift mutation in POC1A, predicted to affect two of the three ...
Adams, Claire, Barrett, Jeff, Barroso, Inês, Chen, Jian Hua, Durbin, Richard, Farooqi, Sadaf, Fitzpatrick, David, Geschwind, Daniel, Huang Doran, Isabel, Hurles, Matt, Kaye, Jane, Keane, Thomas, Kennedy, Karen, Langford, Cordelia, Mccarthy, Shane, Muddyman, Dawn, Owen, Michael, O’Rahilly, Stephen, Palotie, Aarno, Payne, Felicity, Richards, Bren, Savage, David B., SEGNI, Maria, Semple, Robert K., Sleigh, Alison, Soranzo, Nicole, Spector, Tim, Stalker, Jim, Timpson, Nic, Zeggini, Eleftheria   +29 more
core   +3 more sources

Insulin resistance metabolic stress and atherosclerosis [PDF]

Frontiers in Bioscience, 2012
Atherosclerosis, a pathological process that underlies the development of cardiovascular disease, is the primary cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). T2DM is characterized by hyperglycemia and insulin resistance (IR), in which target tissues fail to respond to insulin.
Meghana, Pansuria, Hang, Xi, Le, Li, Xiao-Feng, Yang, Hong, Wang   +4 more
openaire   +2 more sources

Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis [PDF]

, 2020
Background A non-invasive method to grade the severity of steatohepatitis and liver fibrosis is magnetic resonance imaging (MRI) based corrected T1 (cT1).
Banerjee, R, Banerjee, R, Bell, J.D., Bell, J.D., Hemingway, H., Hemingway, H., Hingorani, A.D., Hingorani, A.D., Kelly, M., Kelly, M., McGonigle, J., McGonigle, J., Neubauer, S., Neubauer, S., Nicholls, R.C., Nicholls, R.C., Parisinos, C.A., Parisinos, C.A., Patel, R.S., Patel, R.S., Thomas, E.L., Thomas, E.L., Wilman, H., Wilman, H., Yaghootkar, H., Yaghootkar, H.   +25 more
core   +3 more sources

Animal models of NASH: getting both pathology and metabolic context right [PDF]

, 2015
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of referral to liver clinics, and its progressive form, non-alcoholic steatohepatitis (NASH), can lead to cirrhosis and end-stage liver disease.
Larter, Claire Z., Yeh, Matthew M.
core   +1 more source

Sulfasalazine colon-specific drug delivery by selenium nanoparticle

Journal of Trace Elements and Minerals, 2022
Background: The goal was to assess the specific colon delivery and investigation of synergistic anti-inflammatory effects of the selenium nanoparticle (SeNPs) as a bioactive carrier for oral administration.
Alireza Hashemzadeh, Fereshteh Asgharzadeh, Atieh Yaghoubi, Seyedeh Elnaz Nazari, Seyed Mahdi Hassanian, Amir Avan, Majid Rezaei, Saman Soleimanpour, Majid Khazaei   +8 more
doaj   +1 more source

Exploring the metabolic network of the epidemic pathogen Burkholderia cenocepacia J2315 via genome-scale reconstruction [PDF]

, 2011
BACKGROUND: Burkholderia cenocepacia is a threatening nosocomial epidemic pathogen in patients with cystic fibrosis (CF) or a compromised immune system. Its high level of antibiotic resistance is an increasing concern in treatments against its infection.
Fang, K., Zhao, H., Changyue Sun, Lam, M.C., Chang, S., Zhang, K., Panda, G., Godinho, M., Martins Dos Santos, V.A.P., Wang, J.   +9 more
core   +2 more sources