Results 61 to 70 of about 1,443,560 (303)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Origin, mechanism and molecular basis of weed resistance to herbicides

Plant Protection Science, 2004
This review summarises information from the literature and experimental experience of the authors in research on weed resistance to herbicides. Factors conditioning the origin of resistance are described.
Daniela Chodová, Jan Mikulka, Marie Kočová, Jaroslav Salava   +3 more
doaj   +1 more source

Metabolic regulation of systemic acquired resistance

Current Opinion in Plant Biology, 2021
Plants achieve an optimal balance between growth and defense by a fine-tuned biosynthesis and metabolic inactivation of immune-stimulating small molecules. Recent research illustrates that three common hubs are involved in the cooperative regulation of systemic acquired resistance (SAR) by the defense hormones N-hydroxypipecolic acid (NHP) and ...
openaire   +2 more sources

Muscular diacylglycerol metabolism and insulin resistance [PDF]

Physiology & Behavior, 2008
Failure of insulin to elicit an increase in glucose uptake and metabolism in target tissues such as skeletal muscle is a major characteristic of non-insulin dependent type 2 diabetes mellitus. A strong correlation between intramyocellular triacylglycerol concentrations and the severity of insulin resistance has been found and led to the assumption that
Timmers, S., Schrauwen, P., de Vogel, J.
openaire   +3 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Mechanisms of pyrethroid resistance inHaematobia irritans (Muscidae) from Mato Grosso do Sul state, Brazil

Revista Brasileira de Parasitologia Veterinária
Horn fly resistance to pyrethroid insecticides occurs throughout Brazil, but knowledge about the involved mechanisms is still in an incipient stage. This survey was aimed to identify the mechanisms of horn fly resistance to cypermethrin in Mato Grosso do
Antonio Thadeu Medeiros Barros, Teresinha Tizu Sato Schumaker, Wilson Werner Koller, Guilherme Marcondes Klafke, Thais Aguiar de Albuquerque, Rodrigo Gonzalez   +5 more
doaj   +1 more source

Metabolomics to unveil and understand phenotypic diversity between pathogen populations [PDF]

, 2010
Visceral leishmaniasis is caused by a parasite called Leishmania donovani, which every year infects about half a million people and claims several thousand lives. Existing treatments are now becoming less effective due to the emergence of drug resistance.
A Kamleh, A Scalbert, AK Chavali, Andris Jankevics, BO Keller, C Bern, C Christin, CC HsuChen, D Kumar, David G. Watson, DS Wishart, E Cauchetier, E Fahy, F Chappuis, F Hong, FR Opperdoes, G Barratt, Graham H. Coombs, H Ogata, HC Maltezou, HJ Atherton, HP de Koning, HW Murray, J Alvar, J Trygg, J Vandesompele, JC Mottram, Jean-Claude Dujardin, JV Olsen, K Zhang, K Zhang, Kirstyn Brunker, KW Tintaya, M Basselin, M Basselin, M Rakotomanga, MA Basinger, MA Doyle, MA Kamleh, MA Kamleh, MB Eisen, MK Wassef, MZ Alam, N Mbongo, N Van Meirvenne, R Breitling, R Breitling, R Breitling, RA Scheltema, RA Scheltema, RA Scheltema, Rainer Breitling, Richard A. Scheltema, Ruben t'Kindt, S Rijal, S Sundar, Saskia Decuypere, Suman Rijal, T Laurent, T Naderer, Timothy G. Geary, VP Shah, W Windig, WB Dunn   +63 more
core   +6 more sources

Insulin resistance pathogenesis in metabolic obesity [PDF]

Biomeditsinskaya Khimiya, 2015
In this review we discuss the molecular mechanisms of insulin resistance concomitant with metabolic inflammation. We also analyze the world results of experimental and clinical studies which aimed at identifying the molecular targets for the development of new prevention and treatment of insulin resistance.
L S, Litvinova, E V, Kirienkova, I O, Mazunin, M A, Vasilenko, N S, Fattakhov   +4 more
openaire   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Chain formation mediated by Escherichia coli immunoglobulin-binding proteins EibD and EibG depends on expression levels and localization of proteins

Scientific Reports
Escherichia coli expresses immunoglobulin-binding proteins (Eib), a subgroup of trimeric autotransporter adhesins (TAA). Subtypes of Eib proteins mediate unique chain-like adherence patterns and autoaggregation.
Lena-Sophie Swiatek, Katharina Schaufler, Jack C. Leo   +2 more
doaj   +1 more source