Results 91 to 100 of about 1,277,970 (342)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Comparison of hepatic enzymes between japanese men with and without metabolic syndrome [PDF]

, 2007
We compared the levels of hepatic enzymes in 220 Japanese men with metabolic syndrome with those in age and sex-matched subjects without the syndrome.
Makino, Hirofumi, Matsumoto, Sumiko, Miyatake, Nobuyuki, Numata, Takeyuki   +3 more
core   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

The burden of obesity in the current world and the new treatments available: focus on liraglutide 3.0 mg

Diabetology & Metabolic Syndrome, 2017
The prevalence of obesity increases worldwide. Treating obesity and its associated health problems has a significant economic impact on health care systems.
Marcio C. Mancini, Maria Edna de Melo
doaj   +1 more source

Efficacy of high-dose versus low-dose vitamin D supplementation on serum levels of inflammatory factors and mortality rate in severe traumatic brain injury patients: study protocol for a randomized placebo-controlled trial

Trials, 2020
Background Traumatic brain injury (TBI) is the most common trauma worldwide and is a leading cause of injury-related death and disability. Inflammation is initiated as a result of the TBI, which is in association with severity of illness and mortality in
Seyed Mostafa Arabi, Alireza Sedaghat, Mohammad Reza Ehsaei, Mohammad Safarian, Golnaz Ranjbar, Hamid Rezaee, Reza Rezvani, Hamed Tabesh, Abdolreza Norouzy   +8 more
doaj   +1 more source

Monitoring and prevalence rates of metabolic syndrome in military veterans with serious mental illness [PDF]

, 2011
Background: Cardiovascular disease is the leading cause of mortality among patients with serious mental illness (SMI) and the prevalence of metabolic syndrome-a constellation of cardiovascular risk factors-is significantly higher in these patients than ...
A Jennex, Alex J. Mitchell, AM Kilbourne, AM Kilbourne, AP John, CH Hennekens, CS Hankin, CU Correll, CW Colton, D Taylor, D Vancampfort, DW Haupt, EH Morrato, EH Morrato, EH Morrato, ES Ford, HA Nasrallah, HJ Cohen, J Bobes, J Cardenas, J Meyer, J Rejas, JA Lieberman, JH Thakore, Joshua Kane, JP McEvoy, JW Goethe, JW Newcomer, JW Newcomer, KM Saari, L Shi, LE Kazis, LE Kazis, M Barnett, M de Hert, M Strassnig, Mark S. Bauer, MC Ryan, MP Garcia-Portilla, P Mackin, PA Keller, R Basu, R van Winkel, R van Winkel, R van Winkel, RG McCreadie, S Brown, S Mukherjee, Sameed Ahmed M. Khatana, SH Jones, SL Krein, SR Marder, T Cohn, TA Cohn, TR Barnes, Tracey H. Taveira, U Osby, Wen-Chih Wu, Y Levkovitz   +58 more
core   +5 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Metabolic syndrome in healthcare personnel at the University of Antioquia-Colombia: LATINMETS study

Nutrición Hospitalaria, 2013
Introduction: Hypertension (HTN), atherogenic dyslipidemia, an increased glycemia in a fasting state, and abdominal obesity (AO), constitute a cluster of risk factors for cardiovascular disease named metabolic syndrome (MS).
Laura I. González-Zapata, Gloria Cecilia Deossa, Julia Monsalve-Álvarez, Juliana Díaz-García, Nancy Babio, Jordi Salas-Salvado   +5 more
doaj   +1 more source

Age at menarche and its association with the metabolic syndrome and its components [PDF]

, 2011
The metabolic syndrome is a major public health challenge and identifies persons at risk for diabetes and cardiovascular disease. The aim of this study was to examine the association between age at menarche and the metabolic syndrome (IDF and NCEP ATP ...
Döring, Angela, Heier, Margit, Huth, Cornelia, Kowall, Bernd, Meisinger, Christa, Peters, Annette, Rathmann, Wolfgang, Stöckl, Doris, Stöckl, Heidi, Thorand, Barbara   +9 more
core   +1 more source

Expanding Hereditary Spastic Paraplegias Limits: Biallelic SPAST Variants in Cerebral Palsy Mimics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegias (HSP) are rare neurodegenerative disorders marked by spasticity and lower limb weakness. The most common type, SPG4, is usually autosomal dominant and caused by SPAST gene variants, typically presenting as pure HSP.
Gregorio A. Nolasco, Mònica Roldán, Yalda Jamshidi, Ioannis Georvasilis, Rocío Jadraque Rodríguez, Reza Boostani, Ali Shoeibi, Lluís Armengol, Anna Codina, Ehsan Ghayoor Karimiani, Cristina Hernando‐Davalillo, Loreto Martorell, María Luisa Ramírez Almaraz, Jordi Muchart, Carlos Ortez, Andrés Nascimento, Roser Urreizti, Daniel Natera‐de Benito, Mercedes Serrano   +18 more
wiley   +1 more source