Results 81 to 90 of about 4,251,211 (372)

Physical Activity, Cardiorespiratory Fitness, and the Metabolic Syndrome

Nutrients, 2019
Both observational and interventional studies suggest an important role for physical activity and higher fitness in mitigating the metabolic syndrome. Each component of the metabolic syndrome is, to a certain extent, favorably influenced by interventions
J. Myers, P. Kokkinos, Eric Nyelin
semanticscholar   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Metabolic Syndrome and Migraine [PDF]

Frontiers in Neurology, 2012
Migraine and metabolic syndrome are highly prevalent and costly conditions. The two conditions coexist, but it is unclear what relationship may exist between the two processes. Metabolic syndrome involves a number of findings, including insulin resistance, systemic hypertension, obesity, a proinflammatory state, and a prothrombotic state.
Sachdev, Amit, Marmura, Michael J
openaire   +4 more sources

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Natriuretic peptides and cardiovascular damage in the metabolic syndrome. Molecular mechanisms and clinical implications [PDF]

, 2010
Natriuretic peptides are endogenous antagonists of vasoconstrictor and salt- and water-retaining systems in the body's defence against blood pressure elevation and plasma volume expansion, through direct vasodilator, diuretic and natriuretic properties ...
ALONZO, ALESSANDRO, Rossi C, RUBATTU, Speranza Donatella, SAVOIA, Carmine, VOLPE, Massimo   +4 more
core   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Microbiome as a biomarker and therapeutic target in pancreatic cancer

BMC Microbiology
Studying the effects of the microbiome on the development of different types of cancer has recently received increasing research attention. In this context, the microbial content of organs of the gastrointestinal tract has been proposed to play a ...
Ghazaleh Pourali, Danial Kazemi, Amir Shayan Chadeganipour, Mahshid Arastonejad, Sara Naghizadeh Kashani, Roozbeh Pourali, Mina Maftooh, Hamed Akbarzade, Hamid Fiuji, Seyed Mahdi Hassanian, Majid Ghayour-Mobarhan, Gordon A. Ferns, Majid Khazaei, Amir Avan   +13 more
doaj   +1 more source

CURRENT RECOMMENDATIONS ON RISK STRATIFICATION AND SUDDEN CARDIAC DEATH PREVENTION IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY (BASED ON THE 2011 RECOMMENDATIONS BY THE AMERICAN COLLEGE OF CARDIOLOGY / AMERICAN HEART ASSOCIATION)

Кардиоваскулярная терапия и профилактика, 2013
One of the clinical scenarios of hypertrophic cardiomyopathy (HCMP) is sudden cardiac death (SCD). The stratification of SCD risk is the key component of defining the therapeutic strategy in HCMP patients.
E. V. Privalova, V. Yu. Kaplunova, N. V. Khabarova, G. A. Shakaryants, Yu. N. Belenkov   +4 more
doaj   +1 more source

The metabolic syndrome adds utility to the prediction of mortality over its components: The Vietnam Experience Study [PDF]

, 2009
Background\ud The metabolic syndrome increases mortality risk. However, as “non-affected” individuals may still have up to two risk factors, the utility of using three or more components to identify the syndrome, and its predictive advantage over ...
Anna C. Phillips, Ardern, Batty, Batty, Catharine R. Gale, Douglas Carroll, Eberly, Ford, Ford, G. David Batty, G. Neil Thomas, Ho, Hu, Hunt, Isomaa, Kannel, Katzmarzyk, Lakka, Malik, Onat, Sattar, Simons, Smith, Sundstrom, Sundström   +24 more
core   +1 more source

Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome

Nature, 2015
The intestinal tract is inhabited by a large and diverse community of microbes collectively referred to as the gut microbiota. While the gut microbiota provides important benefits to its host, especially in metabolism and immune development, disturbance ...
B. Chassaing, O. Koren, Julia Goodrich, Angela C. Poole, S. Srinivasan, R. Ley, A. Gewirtz   +6 more
semanticscholar   +1 more source