Results 61 to 70 of about 774,651 (247)
Microbiome as a biomarker and therapeutic target in pancreatic cancer
BMC MicrobiologyStudying the effects of the microbiome on the development of different types of cancer has recently received increasing research attention. In this context, the microbial content of organs of the gastrointestinal tract has been proposed to play a ...
Ghazaleh Pourali +13 more
doaj +1 more source
Metabolic Syndrome and Neuroprotection [PDF]
Frontiers in Neuroscience, 2018 Introduction: Over the years the prevalence of metabolic syndrome (MetS) has drastically increased in developing countries as a major byproduct of industrialization. Many factors, such as the consumption of high-calorie diets and a sedentary lifestyle, bolster the spread of this disorder.
Melisa Etchegoyen +7 more
openaire +4 more sources
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Metabolic syndrome: To be or not to be?
Annals of Medicine, 2006 The metabolic syndrome (MetS), a constellation of cardiovascular risk factors, has become one of the major public‐health challenges worldwide 1.
Markku, Laakso, Petri T, Kovanen
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PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Кардиоваскулярная терапия и профилактика, 2013 One of the clinical scenarios of hypertrophic cardiomyopathy (HCMP) is sudden cardiac death (SCD). The stratification of SCD risk is the key component of defining the therapeutic strategy in HCMP patients.
E. V. Privalova +4 more
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The effects of vitamin and mineral supplementation on women with gestational diabetes mellitus
BMC Endocrine Disorders, 2021 Background The effects of vitamin and mineral supplementation on women with gestational diabetes mellitus (GDM) have not been well established. We conduct a meta-analysis to evaluate the effects of vitamin and mineral supplementation on glycemic control,
Dandan Li +4 more
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Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Diabetology & Metabolic Syndrome, 2017 The prevalence of obesity increases worldwide. Treating obesity and its associated health problems has a significant economic impact on health care systems.
Marcio C. Mancini, Maria Edna de Melo
doaj +1 more source