Results 101 to 110 of about 429,140 (308)

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Parent-offspring transmission of adipocytokine levels and their associations with metabolic traits [PDF]

, 2011
Adipose tissue secreted cytokines (adipocytokines) have significant effects on the physiology and pathology of human metabolism relevant to diabetes and cardiovascular disease. We determined the relationship of the pattern of these circulating hormones
Nasser M. Al-Daghri, Alkharfy Khalid M., Shaun B Sabico, Omar S. Al-Attas, Khalid M. Alkharfy, Kumar Sudhesh, Sabico, Shaun, Sudhesh Kumar, George P Chrousos, Omar S Al-Attas, Alokail, Majed S., Shaun B. Sabico, Al-Attas, Omar S., Al-Attas Omar S., Majed S. Alokail, Al-Daghri, Nasser M., Greg C Gibson, Sabico Shaun B., Greg C. Gibson, Majed S Alokail, Sobhy M. Yakout, Gibson, Greg, Yakout Sobhy M., Al-Daghri Nasser M., Chrousos, George P., Alokail Majed S., Kumar, Sudhesh, Nasser M Al-Daghri, Yakout, Sobhy M., Gibson Greg C., Sobhy M Yakout, Chrousos George P., Alkharfy, Khalid M., George P. Chrousos, Khalid M Alkharfy   +34 more
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The Prevalence of Metabolic Syndrome in Iran: A Systematic Review and Meta-analysis

Iranian Journal of Public Health, 2018
Background: Metabolic syndrome (MS)is a collection of metabolic disorders which leads to early cardiovascular disease and diabetes type II. Regarding the wide range of its prevalence in Iran, this systematic review and meta-analysis determined the ...
Saeideh MAZLOOMZADEH, Zahra RASHIDI KHAZAGHI, Nouraddin MOUSAVINASAB   +2 more
doaj  

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Metabolic syndrome, the leptin gene and kidney disease in non-diabetic black South Africans

, 2008
Includes abstract.Includes bibliographical references (leaves 226-256).Obesity is a worldwide problem and is a factor in the pathogenesis of the metabolic syndrome and kidney disease through the development of obesity-related hypertension and ...
Okpechi, Ikechi Gareth
core  

Dietary Protein and Blood Pressure: A Systematic Review [PDF]

, 2010
Background - Elevated blood pressure (BP), which is a major risk factor for cardiovascular disease, is highly prevalent worldwide. Recently, interest has grown in the role of dietary protein in human BP.
Wieke Altorf-van der Kuil, Bakker, S.J.L., Bakker, Stephan J. L., Navis, G., Johanna M Geleijnse, Geleijnse, J.M., Baak, M.A. van, Geleijnse Johanna M., Kuil, W.A. van der, Bakker Stephan J. L., van't Veer, Pieter, Bakker, Stephan J. L.; id_orcid, Marleen A van Baak, Geleijnse, Johanna M., Mariëlle F Engberink, van Baak, M.A., Mariëlle F. Engberink, Engberink, Marielle F., Stephan J L Bakker, Altorf-van der Kuil, Wieke, van Baak Marleen A., Pieter van 't Veer, Brink, Elizabeth J., Wieke Altorf – van der Kuil, Bakker, S.J., van Baak, Marleen A., Johanna M. Geleijnse, Brink Elizabeth J., Veer, P., van 't, Engberink Mariëlle F., Brink, E.J., van 't Veer Pieter, Veer, P. van't, Gerjan Navis, van 't Veer, P., Marleen A. van Baak, Navis, Gerjan, Elizabeth J. Brink, Engberink, M.F., Stephan J. L. Bakker, van der Kuil, W., Navis Gerjan, Altorf-van der Kuil, W., Baak, M.A., van, Elizabeth J Brink, Altorf, W., Altorf – van der Kuil Wieke   +46 more
core   +1 more source

Sex‐Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu‐erh Tea

Advanced Science, EarlyView.
Pu‐erh tea's key component, theabrownin (TB), lowers blood glucose in a sex‐specific manner. In females, estrogen boosts intestinal MUC2 production, which dramatically enhances TB's ability to inhibit the carbohydrate‐digesting enzyme α‐glucosidase.
Yang Li, Junliang Kuang, Dan Zheng, Jieyi Wang, Kun Ge, Chun Qu, Xiaojiao Zheng, Zhenxing Ren, Fengjie Huang, Mingliang Zhao, Yimin Sun, Huiheng Zhang, Keke Ding, Xixi Xia, Yajun Tang, Lu Liu, Jian Zhou, Fei Gao, Xiaohui Ma, Yongquan Xu, Guoxiang Xie, Aihua Zhao, Wei Jia   +22 more
wiley   +1 more source

Low-grade inflammation can partly explain the association between the metabolic syndrome and either coronary artery disease or severity of peripheral arterial disease: the CODAM study

, 2009
Background Low-grade inflammation has been hypothesized to underlie the coronary artery disease (CAD) risk associated with the metabolic syndrome, but the evidence is not conclusive.
Jansen, E.H., Stehouwer, C. D. A., van der Kallen, C.J., Blaak, E.E., van der Kallen, C. J. H., van Greevenbroek, M.M.; id_orcid, van Greevenbroek, M. M. J., van Greevenbroek, M.M., Schalkwijk, C.G.; id_orcid, Schalkwijk, C. G., Feskens, E.J., Kallen, C.J., Feskens, E. J. M., Schalkwijk, C.G., Feskens, E.J.M., van der Kallen, C.J.; id_orcid, Greevenbroek, M.M., Stehouwer, C.D.; id_orcid, Jansen, E. H. J. M., Jacobs, M., Blaak, E. E., Stehouwer, C.D., Ferreira, I.   +22 more
core   +1 more source

Retinol-binding protein 4 in polycystic ovary syndrome--association with steroid hormones and response to pioglitazone treatment [PDF]

, 2009
CONTEXT: Polycystic ovary syndrome (PCOS) is frequently associated with insulin resistance. OBJECTIVE: The aim of the study was to investigate a putative role of the adipokines retinol-binding protein 4 (RBP4), adiponectin, and visfatin in a cohort of ...
Aigner, Elmar, Patsch, Wolfgang, Bachofner, Nora, Klein, Kerstin, Datz, Christian, Hohla, Florian, De Geyter, Christian   +6 more
core   +1 more source

PRC2.1 Coordinates Peri‐Nucleolar H3K27me3‐Enriched Heterochromatin Organization and NPM1 Pentamerization to Maintain Nucleolar Integrity

Advanced Science, EarlyView.
PRC2.1(PCL2)‐coordinated H3K27me3‐enriched PNH establishes a spatial scaffold crucial for nucleolar integrity. As a crucial coordinator, PCL2 links PRC2.1 to chromatin organization and NPM1 assembly. This network‐based model reveals how chromatin modifications and nucleolar components cooperatively maintain nucleolar architecture, revealing novel ...
Lina Zhu, Wenqin Wang, Shuyun Chen, Gangyi Zhu, Zhen Wu, Yue Gu, Jingwen Xiong, Xu Zhang, Heng Liu, Kyoichi Isono, Youming Zhang, Jingjing Cao, Xiangzhi Li   +12 more
wiley   +1 more source