Results 111 to 120 of about 429,140 (308)

Prevalence of Metabolic Syndrome among Truck Drivers and Its Relation to Shift Work

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2012
Background and Objectives: Recent studies suggest that shift work is associated with metabolic syndrome in the shift workers. The population of truck drivers is of particular interest, because they frequently work irregular shifts.
Z Z Yazdi, M Sareshtehdary, MH Tayefi
doaj  

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Excess portal venous long-chain fatty acids induce syndrome X via HPA axis and sympathetic activation [PDF]

, 2000
We tested the hypothesis that excessive portal venous supply of long-chain fatty acids to the liver contributes to the development of insulin resistance via activation of the hypothalamus-pituitary-adrenal axis (HPA axis) and sympathetic system.
Scheurink, AJW, Strubbe, JH, Keizer, Klaasjan,, Kuipers, Folkert,, Kuipers, F, Scheurink, Anton J.W.,, Benthem, L, Kuipers, F; id_orcid, Keizer, Klaas-Jan, Wiegman, Coen H.,, Strubbe, Jan H.,, Boer, Sietse F. de,, Steffens, Anton B.,, Steffens, AB, De Boer, SF, Benthem, Lambertus,, Wiegman, CH   +16 more
core  

Impact of FTO genotypes on BMI and weight in polycystic ovary syndrome : a systematic review and meta-analysis [PDF]

, 2012
Aims/hypothesis FTO gene single nucleotide polymorphisms (SNPs) have been shown to be associated with obesity-related traits and type 2 diabetes. Several small studies have suggested a greater than expected effect of the FTO rs9939609 SNP on weight in ...
Lerchbaum, E., Straczkowski, M., Malecki, MT, Vcelak, J, Tan, S., Wojciechowski, Piotr, B. Obermayer-Pietsch, Bendlova, B., Grigorescu, F., McCarthy, M. I., S. Franks, Lerchbaum, E, Lipowska, A, Rys, P., Hinney, A, Goodarzi, M. O., Azziz, R., Straczkowski, M, Bendlova, B, P. Lukasova, S. Tan, Azziz, Ricardo, McCarthy, Mark, F. Grigorescu, P. Rys, M. T. Malecki, Lukasova, P, J. Vcelak, M. I. McCarthy, null null, Attaoua, R, M. O. Goodarzi, Ewens, KG, B. Bendlova, Małecki, Maciej, Rys, P, Strauss III, J. F., Franks, S., Lukasova, P., Wojciechowski, P, McCarthy, MI, M. Straczkowski, R. Azziz, Strauss, JF, A. Lipowska, K. G. Ewens, Kowalska, I., Malecki, M. T., Barber, TM, Obermayer-Pietsch, B., Attaoua, R., R. Attaoua, Strauss III, JF, Grigorescu, F, J. F. Strauss, Tan, S, Kowalska, I, Wojciechowski, P., Barber, T. M., Ewens, K. G., Hinney, A., Strauss, J. F., III, P. Wojciechowski, McCarthy, Mark I., Vcelak, J., E. Lerchbaum, Goodarzi, MO, HASH(0x55a680537f60), Franks, S, Obermayer-Pietsch, B, T. M. Barber, I. Kowalska, Lipowska, A., A. Hinney, Azziz, R   +74 more
core   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Arterial distensibility in adolescents: the influence of adiposity, the metabolic syndrome, and classic risk factors.

, 2005
BACKGROUND: Atherosclerosis develops from childhood, but the determinants of this preclinical stage remain uncertain. We examined the relations of classic coronary risk factors, adiposity and its associated metabolic disturbances, to arterial ...
Donald, AE, Oliver, C, Whincup, PH, Gilg, JA, Katterhorn, M, Cook, DG, Deanfield, JE   +6 more
core  

Raised TSH is associated with endothelial dysfunction in Metabolic Syndrome: A case control study

Romanian Journal of Internal Medicine, 2017
Introduction. Endothelial dysfunction has been considered as one of the important factors in pathogenesis of Metabolic Syndrome (Met S). Subclinical hypothyroidism (SCH) has also been reported to be associated with Met S.
Ahirwar Ashok Kumar, Singh Archana, Jain Anju, Patra Surajeet Kumar, Goswami Binita, Bhatnagar M.K., Bhattacharjee Jayashree   +6 more
doaj   +1 more source

[Syndrome X vs metabolic syndrome].

Archivos de cardiologia de Mexico, 2007
Himsworth in 1939 postulated that Diabetes Mellitus type 2 (DM2) was not only an insulin deficiency state but also a cellular insulin insensitivity disease. Thirty years later, DeFronzo and Reaven demonstrated that insulin resistance (IR) preceded and predisposed for DM2 and atherosclerotic-cardiovascular-disease (ACVD).
openaire   +1 more source

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Self-rated health in middle-aged and elderly Chinese : distribution, determinants and associations with cardio-metabolic risk factors [PDF]

, 2009
Background: Self-rated health (SRH) has been demonstrated to be an accurate reflection of a person's health and a valid predictor of incident mortality and chronic morbidity.
Oscar H Franco, Xu Lin, Haseli-Mashhadi , Nazanin, Lin Xu, Wang, J. (Jing), Li Huaixing, Qi Qibin, Qibin Qi, Yong Liu, Liu Yong, Yu Zhijie, Xingwang Ye, Li, Huaixing, Huaixing Li, Pan An, Wang Jing, An Pan, Pan, An, Franco Oscar H, Haseli-Mashhadi Nazanin, Lin, Xu, Jing Wang, Yu, Zhijie, Franco, Oscar H., Nazanin Haseli-Mashhadi, Ye, Xingwang, Qi, Qibin, Liu, Y. (Yong), Ye Xingwang, Zhijie Yu   +29 more
core   +1 more source