Results 121 to 130 of about 7,834,690 (307)

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Prevalence of Metabolic Syndrome in a Rural Community in Nigeria

, 2010
The purpose of this study was to assess the prevalence of metabolic syndrome in a Nigerian rural ...
Olajire A. Adegoke, Afolabi A. Salawu, Luqman A. Bisiriyu, Michael O. Balogun, Rasaaq A. Adebayo, Rufus A. Adedoyin   +5 more
core   +1 more source

Insulin Resistance: the Metabolic Syndrome X [PDF]

European Journal of Clinical Nutrition, 2000
  +5 more sources

Effect of Cardiac Rehabilitation Program on Heart Rate Recovery in Coronary Heart Disease

Journal of Tehran University Heart Center, 2016
Background: It has been suggested that the autonomic system function and the metabolic syndrome can significantly affect patients' survival. The aim of the current study was to investigate the impact of the cardiac rehabilitation program on the autonomic
Leila Mahdavi Anari, Mahdieh Ghanbari-Firoozabadi, Zahra Ansari, Mahmoud Emami, Mohammadreza Vafaii Nasab, Mahdieh Nemaiande, Fatemeh Boostany, Mohamadreza Neishaboury   +7 more
doaj  

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Prevalence and clinical characteristics of metabolic syndrome for at-risk people in a rural community

, 2009
BACKGROUND: Substantial socioeconomic and demographic changes have resulted in an increase in the incidence of metabolic syndrome in Korea, especially in aged, postmenopausal women and in rural populations. As rural populations age, metabolic syndrome is
오의금
core   +1 more source

Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy

Advanced Science, EarlyView.
L‐cysteine‐configured chiral polyurethane nanoparticles suppress ocular inflammation and reduce extracellular matrix (ECM) degradation in ectopia lentis by regulating macrophages polarization and inhibiting nuclear factor kappa B signaling pathway. By promoting zonular fiber‐associated protein restoration and tissue repair, this minimally invasive ...
Yinuo Wen, Yan Yang, Haihan Gao, Yan Liu, Xinyue Wang, Linghao Song, Ruohong Li, Ao Miao, Jie Xu, Zhennan Zhao, Dan Li, Shenjie Peng, Linzhao Li, Min Zhang, Yonghang Liu, Liren Wang, Tianhui Chen, Yongxiang Jiang   +17 more
wiley   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Relationship Between the Preoperative Body Mass Index and the Resolution of Metabolic Syndrome Following Roux-en-Y Gastric Bypass

, 2012
Background: the increased prevalence of overweight and obesity has reached alarming proportions worldwide and has serious health implications, including an association with an increase in metabolic syndrome.
Arasaki, Carlos Haruo [UNIFESP], Matos, Delcio [UNIFESP], Lopes-Filho, Gaspar Jesus [UNIFESP], Saboya, Carlos [UNIFESP]   +3 more
core   +1 more source

ANALYSIS OF INSULIN RESISTANCE IN VARIOUS COMPONENTS OF METABOLIC SYNDROME

National Journal of Medical Research, 2011
Metabolic syndrome is a collection of health risks that increases chances of developing heart disease. The constellation of metabolic abnormalities includes glucose intolerance, central obesity, dyslipidemia, and hypertension. These conditions can occur
Pankaj Maheria, Deepak Parchwani, Amit Upadhyay, Manoj Kumar Sharma   +3 more
doaj