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Abstract Metabolism consists of a series of reactions that occur within cells of living organisms to sustain life. The process of metabolism involves many interconnected cellular pathways to ultimately provide cells with the energy required to carry out their function.
Ayesha Judge, Michael S. Dodd
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Glucocorticoids, metabolism and metabolic diseases [PDF]
Since the discovery of the beneficial effects of adrenocortical extracts for treating adrenal insufficiency more than 80 years ago, glucocorticoids (GC) and their cognate, intracellular receptor, the glucocorticoid receptor (GR) have been characterized as critical components of the delicate hormonal control system that determines energy homeostasis in ...
Vegiopoulos, Alexandros, Herzig, Stephan
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Fructose Metabolism and Cardiac Metabolic Stress [PDF]
Cardiovascular disease is one of the leading causes of mortality in diabetes. High fructose consumption has been linked with the development of diabetes and cardiovascular disease. Serum and cardiac tissue fructose levels are elevated in diabetic patients, and cardiac production of fructose via the intracellular polyol pathway is upregulated.
M. Annandale +11 more
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NAD+ Metabolism, Metabolic Stress, and Infection [PDF]
Nicotinamide adenine dinucleotide (NAD+) is an essential metabolite with wide-ranging and significant roles in the cell. Defects in NAD+ metabolism have been associated with many human disorders; it is therefore an emerging therapeutic target. Moreover, NAD+ metabolism is perturbed during colonization by a variety of pathogens, either due to the ...
Groth, Benjamin +2 more
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Position Statement on COVID-19 Infection and Diabetes
Coronavirus disease 2019 (COVID-19) has affected millions of lives worldwide, posing unprecedented challenges to global public health. It has infected people of different backgrounds, and from all industries, including healthcare workers.
The Philippine Society of Endocrinology, Diabetes and Metabolism (PSEDM)
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MicroRNAs in metabolism and metabolic disorders [PDF]
MicroRNAs (miRNAs) have recently emerged as key regulators of metabolism. For example, miR-33a and miR-33b have a crucial role in controlling cholesterol and lipid metabolism in concert with their host genes, the sterol-regulatory element-binding protein (SREBP) transcription factors.
Veerle, Rottiers, Anders M, Näär
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Circulating CD25hi B cells, a subset of regulatory B cells in humans, are closely related to inflammation and autoimmune diseases. This study is aimed at investigating the alternation of CD25hi Bregs and their correlation with CD4 effector and regulatory
Jie Zhang +9 more
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Quantifying redox metabolism in the plant metabolic network
The aim of this thesis was to develop and evaluate methods for quantifying redox metabolism in plants. Current methods suffer from a lack of: quantitative measurement; specificity between different redox carriers; and subcellular resolution.
Smith, Edward
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Discovering signaling mechanisms governing metabolism and metabolic diseases with Drosophila [PDF]
There has been rapid growth in the use of Drosophila and other invertebrate systems to dissect mechanisms governing metabolism. New assays and approaches to physiology have aligned with superlative genetic tools in fruit flies to provide a powerful ...
Tsao, Deborah D +6 more
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Background. X-linked adrenoleukodystrophy (ALD) is an inherited peroxisomal metabolism disorder, resulting from the loss-of-function mutation of ATP-binding cassette protein subfamily D1 (ABCD1) gene.
Bingzi Dong +8 more
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