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Essays in Biochemistry, 2020 Abstract Metabolism consists of a series of reactions that occur within cells of living organisms to sustain life. The process of metabolism involves many interconnected cellular pathways to ultimately provide cells with the energy required to carry out their function.
Ayesha Judge, Michael S. Dodd
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Discovering signaling mechanisms governing metabolism and metabolic diseases with Drosophila [PDF]
, 2021 There has been rapid growth in the use of Drosophila and other invertebrate systems to dissect mechanisms governing metabolism. New assays and approaches to physiology have aligned with superlative genetic tools in fruit flies to provide a powerful ...
Tsao, Deborah D +10 more
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NAD+ Metabolism, Metabolic Stress, and Infection [PDF]
Frontiers in Molecular Biosciences, 2021 Nicotinamide adenine dinucleotide (NAD+) is an essential metabolite with wide-ranging and significant roles in the cell. Defects in NAD+ metabolism have been associated with many human disorders; it is therefore an emerging therapeutic target. Moreover, NAD+ metabolism is perturbed during colonization by a variety of pathogens, either due to the ...
Groth, Benjamin +2 more
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Glucocorticoids, metabolism and metabolic diseases [PDF]
Molecular and Cellular Endocrinology, 2007 Since the discovery of the beneficial effects of adrenocortical extracts for treating adrenal insufficiency more than 80 years ago, glucocorticoids (GC) and their cognate, intracellular receptor, the glucocorticoid receptor (GR) have been characterized as critical components of the delicate hormonal control system that determines energy homeostasis in ...
Vegiopoulos, Alexandros, Herzig, Stephan
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Fructose Metabolism and Cardiac Metabolic Stress [PDF]
Frontiers in Pharmacology, 2021 Cardiovascular disease is one of the leading causes of mortality in diabetes. High fructose consumption has been linked with the development of diabetes and cardiovascular disease. Serum and cardiac tissue fructose levels are elevated in diabetic patients, and cardiac production of fructose via the intracellular polyol pathway is ...
M. Annandale +11 more
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, 2021 Energy metabolism at whole body and cellular, and even organelle (i [...
Arie G. Nieuwenhuizen +1 more
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MicroRNAs in Metabolism and Metabolic Diseases [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 2011 Aberrant cholesterol/lipid homeostasis is linked to a number of diseases prevalent in the developed world, including metabolic syndrome, type II diabetes, and cardiovascular disease. We have previously uncovered gene regulatory mechanisms of the sterol regulatory element-binding protein (SREBP) family of transcription factors, which control the ...
V, Rottiers +10 more
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Fructose metabolism and metabolic disease [PDF]
Journal of Clinical Investigation, 2018 Increased sugar consumption is increasingly considered to be a contributor to the worldwide epidemics of obesity and diabetes and their associated cardiometabolic risks. As a result of its unique metabolic properties, the fructose component of sugar may be particularly harmful.
Herman, Mark A +3 more
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Serotonergic Regulation of Hepatic Energy Metabolism [PDF]
, 2021 The liver is a vital organ that regulates systemic energy metabolism and many physiological functions. Nonalcoholic fatty liver disease (NAFLD) is the commonest cause of chronic liver disease and end-stage liver failure.
윤차현 +4 more
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GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride Metabolism [PDF]
, 2019 Lipoprotein lipase (LPL), identified in the 1950s, has been studied intensively by biochemists, physiologists, and clinical investigators. These efforts uncovered a central role for LPL in plasma triglyceride metabolism and identified LPL mutations as a ...
He, Cuiwen +13 more
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