Results 21 to 30 of about 4,144,108 (357)

Association between cognitive performance and cortical glucose metabolism in patients with mild Alzheimer's disease [PDF]

, 2005
Background: Neuronal and synaptic function in Alzheimer's disease (AD) is measured in vivo by glucose metabolism using positron emission tomography (PET). Objective: We hypothesized that neuronal activation as measured by PET is a more sensitive index of
A. Drzezga, A.L.W. Bokde, Baron JC, C. Born, Collins DL, G. Leinsinger, H. Hampel, H.-J. Moeller, Herholz K, Herscovitch P, Ibanez V, Ishii K, J. Thissen, Jueptner M, M. Schwaiger, McKhann G, Meltzer CC, Meltzer CC, Mentis MJ, Mentis MJ, P. Bartenstein, Pietrini P, Pietrini P, Pietrini P, Rapoport SI, S.J. Teipel, Sokoloff L, W. Dong   +27 more
core   +1 more source

The Effect of Liraglutide on Epicardial Adipose Tissue in Type 2 Diabetes

Journal of Diabetes Research, 2021
Objective. To study the effect of liraglutide on the thickness of epicardial adipose tissue (EAT) in type 2 diabetes mellitus (T2DM) patients with abdominal obesity. Methods.
Na Zhao, Xiaoying Wang, Yongbo Wang, Junjie Yao, Chunhong Shi, Jianling Du, Ran Bai   +6 more
doaj   +1 more source

Iron Metabolism in Obesity and Metabolic Syndrome [PDF]

International Journal of Molecular Sciences, 2020
Obesity is an excessive adipose tissue accumulation that may have detrimental effects on health. Particularly, childhood obesity has become one of the main public health problems in the 21st century, since its prevalence has widely increased in recent years.
Álvaro González-Domínguez, Francisco M. Visiedo-García, Jesús Domínguez-Riscart, Raúl González-Domínguez, Rosa M. Mateos, Alfonso María Lechuga-Sancho   +5 more
openaire   +6 more sources

NAD+ Metabolism, Metabolic Stress, and Infection [PDF]

Frontiers in Molecular Biosciences, 2021
Nicotinamide adenine dinucleotide (NAD+) is an essential metabolite with wide-ranging and significant roles in the cell. Defects in NAD+ metabolism have been associated with many human disorders; it is therefore an emerging therapeutic target. Moreover, NAD+ metabolism is perturbed during colonization by a variety of pathogens, either due to the ...
Groth, Benjamin, Venkatakrishnan, Padmaja, Lin, Su-Ju   +2 more
openaire   +6 more sources

Endoscopic Delivery Method Using a Retrieval Net for Patients with Small-Bowel Capsule Endoscopy Stagnation in the Stomach

Gastroenterology Research and Practice, 2021
With the increasing use of capsule endoscopy (CE), screening tests for the small bowel can be performed with minimal invasiveness. However, occasionally, the entire small bowel cannot be observed because of decreased peristalsis of the stomach.
Akihiko Sumioka, Shiro Oka, Akiyoshi Tsuboi, Issei Hirata, Sumio Iio, Hidenori Tanaka, Ken Yamashita, Takahiro Kotachi, Ryo Yuge, Yuji Urabe, Shinji Tanaka   +10 more
doaj   +1 more source

LC-MS proteomics analysis of the iInsulin/IGF-1-deficient Caenorhabditis elegans daf-2(e1370) mutant reveals extensive restructuring of intermediary metabolism [PDF]

, 2014
The insulin/IGF-1 receptor is a major known determinant of dauer formation, stress resistance, longevity, and metabolism in Caenorhabditis elegans. In the past, whole-genome transcript profiling was used extensively to study differential gene expression ...
Braeckman, Bart, Brewer, Heather M, Camp, David G, II, Depuydt, Geert, Petyuk, Vladislav A, Smith, Richard D, Smolders, Arne, Xie, Fang   +7 more
core   +2 more sources

A Minimal Model of Metabolism Based Chemotaxis [PDF]

, 2010
Since the pioneering work by Julius Adler in the 1960's, bacterial chemotaxis has been predominantly studied as metabolism-independent. All available simulation models of bacterial chemotaxis endorse this assumption.
AM Stock, BL Taylor, BL Taylor, Christopher V. Rao, CS Vegge, D Bray, D Bray, D Stock, E Smith, Ezequiel A. Di Paolo, G Alexandre, G Alexandre, G Alexandre, GH Wadhams, GL Hazelbauer, GN Cohen-Ben-Lulu, H Morowitz, HC Berg, HC Berg, HL Packer, HR Maturana, I Sarand, I Zhulin, J Adler, J Letelier, J Stock, JC Edwards, JJ Falke, JL Spudich, JP Armitage, JS Parkinson, K Prasad, K Ruiz-Mirazo, M Eisenbach, M Eisenbach, Matthew D. Egbert, MD Egbert, MD Egbert, MJ Borrok, N Kresge, PA Thomason, R Barak, R Rosen, RA Goldstein, RK Clayton, RM Macnab, SA Kauffman, SA Kauffman, SE Greer-Phillips, SS Andrews, T Ganti, T Schweinitzer, VA Bespalov, WR Ashby, X Barandiaran, Xabier E. Barandiaran, XE Barandiaran, Y Jeziore-Sassoon, Y Sowa, Z Xie   +59 more
core   +5 more sources

MicroRNAs in Metabolism and Metabolic Diseases [PDF]

Cold Spring Harbor Symposia on Quantitative Biology, 2011
Aberrant cholesterol/lipid homeostasis is linked to a number of diseases prevalent in the developed world, including metabolic syndrome, type II diabetes, and cardiovascular disease. We have previously uncovered gene regulatory mechanisms of the sterol regulatory element-binding protein (SREBP) family of transcription factors, which control the ...
S H Najafi-Shoushtari, Veerle Rottiers, S Gurumurthy, Fjoralba Kristo, Lei Zhong, Nabeel Bardeesy, Y Li, Robert E. Gerszten, David E. Cohen, Anders M. Näär, Raul Mostoslavsky   +10 more
openaire   +3 more sources

Fructose Metabolism and Cardiac Metabolic Stress [PDF]

Frontiers in Pharmacology, 2021
Cardiovascular disease is one of the leading causes of mortality in diabetes. High fructose consumption has been linked with the development of diabetes and cardiovascular disease. Serum and cardiac tissue fructose levels are elevated in diabetic patients, and cardiac production of fructose via the intracellular polyol pathway is upregulated.
J. P. H. Neale, H. A. Ambalawanar, Kimberley M. Mellor, Kimberley M. Mellor, X. Li, A. H. L. Chau, Parisa Koutsifeli, Marco Annandale, L. J. Daniels, L. J. Daniels, L.M.D. Delbridge, S. L. James   +11 more
openaire   +6 more sources

PNPLA3 148M/M Is More Susceptible to Palmitic Acid-Induced Endoplasmic Reticulum Stress-Associated Apoptosis in HepG2 Cells

International Journal of Endocrinology, 2023
Background. Patatin-like phospholipase domain-containing 3 (PNPLA3) is a major susceptibility gene for nonalcoholic fatty liver disease (NAFLD), and its rs738409 (I148M) polymorphism is associated with the occurrence and progression of NAFLD. Endoplasmic
Yunzhi Chen, Xuemei Yan, Tian Wang, Hongrong Deng, Xiaojie Deng, Fen Xu, Hua Liang   +6 more
doaj   +1 more source