Results 31 to 40 of about 5,419,102 (403)

Identification and Functional Characterization of a Novel Variant in the SEMA3A Gene in a Chinese Family with Kallmann Syndrome

open access: yesInternational Journal of Endocrinology, 2022
Background. Kallmann syndrome (KS) is a rare genetic disease characterized by the reproductive system and olfactory dysplasia due to the defective migration of gonadotropin-releasing hormone (GnRH) neurons.
Meng Shu   +7 more
doaj   +1 more source

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

open access: yesNature, 2011
Metabolomics studies hold promise for the discovery of pathways linked to disease processes. Cardiovascular disease (CVD) represents the leading cause of death and morbidity worldwide.
Zeneng Wang   +17 more
semanticscholar   +1 more source

Cancer metabolism at a glance [PDF]

open access: yes, 2016
A defining hallmark of cancer is uncontrolled cell proliferation. This is initiated once cells have accumulated alterations in signaling pathways that control metabolism and proliferation, wherein the metabolic alterations provide the energetic and ...
Gottlieb, Eyal   +5 more
core   +2 more sources

Sodium Butyrate Attenuates Diabetic Kidney Disease Partially via Histone Butyrylation Modification

open access: yesMediators of Inflammation, 2022
Inflammation and fibrosis are the important pathophysiologic processes in diabetic kidney disease (DKD), which is induced by epigenetics, especially histone posttranslational modification (HPTMs).
Tingting Zhou   +11 more
doaj   +1 more source

The Effect of Liraglutide on Epicardial Adipose Tissue in Type 2 Diabetes

open access: yesJournal of Diabetes Research, 2021
Objective. To study the effect of liraglutide on the thickness of epicardial adipose tissue (EAT) in type 2 diabetes mellitus (T2DM) patients with abdominal obesity. Methods.
Na Zhao   +6 more
doaj   +1 more source

MicroRNAs in Metabolism and Metabolic Diseases [PDF]

open access: yesCold Spring Harbor Symposia on Quantitative Biology, 2011
Aberrant cholesterol/lipid homeostasis is linked to a number of diseases prevalent in the developed world, including metabolic syndrome, type II diabetes, and cardiovascular disease. We have previously uncovered gene regulatory mechanisms of the sterol regulatory element-binding protein (SREBP) family of transcription factors, which control the ...
S H Najafi-Shoushtari   +10 more
openaire   +3 more sources

Recombinant Incretin-Secreting Microbe Improves Metabolic Dysfunction in High-Fat Diet Fed Rodents [PDF]

open access: yes, 2017
peer-reviewedThe gut hormone glucagon-like peptide (GLP)-1 and its analogues represent a new generation of anti-diabetic drugs, which have also demonstrated propensity to modulate host lipid metabolism.
Cryan, John F.   +13 more
core   +4 more sources

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

open access: yesJournal of Lipid Research, 2013
Short-chain fatty acids (SCFAs), the end products of fermentation of dietary fibers by the anaerobic intestinal microbiota, have been shown to exert multiple beneficial effects on mammalian energy metabolism.
G. den Besten   +5 more
semanticscholar   +1 more source

Metabolism within the tumor microenvironment and its implication on cancer progression: an ongoing therapeutic target [PDF]

open access: yes, 2018
Since reprogramming energy metabolism is considered a new hallmark of cancer, tumor metabolism is again in the spotlight of cancer research. Many studies have been carried out and many possible therapies have been developed in the last years.
Abdel-Aziz   +431 more
core   +2 more sources

The expression of stlA in Photorhabdus luminescens is controlled by nutrient limitation [PDF]

open access: yes, 2013
Photorhabdus is a genus of Gram-negative entomopathogenic bacteria that also maintain a mutualistic association with nematodes from the family Heterorhabditis.
Bode, Helge Björn   +3 more
core   +11 more sources

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