Results 31 to 40 of about 3,690,314 (381)

Mass Conservation And Inference of Metabolic Networks from High-throughput Mass Spectrometry Data [PDF]

J Comput Biol, vol. 18 (2) pp. 147-54, 2011, 2010
We present a step towards the metabolome-wide computational inference of cellular metabolic reaction networks from metabolic profiling data, such as mass spectrometry. The reconstruction is based on identification of irreducible statistical interactions among the metabolite activities using the ARACNE reverse-engineering algorithm and on constraining ...
arxiv   +1 more source

Peptidoglycan-Mediated Bone Marrow Autonomic Neuropathy Impairs Hematopoietic Stem/Progenitor Cells via a NOD1-Dependent Pathway in db/db Mice

Stem Cells International, 2022
Impairment of bone marrow-derived hematopoietic stem/progenitor cells (HSPCs) contributes to the progression of vascular complications in subjects with diabetes.
Jing Wu, Binghan Zhang, Shengbing Li, Wenwen Chen, Jinning Mao, Ke Li, Dongfang Liu, Yaqian Duan   +7 more
doaj   +1 more source

A Minimal Model of Metabolism Based Chemotaxis [PDF]

, 2010
Since the pioneering work by Julius Adler in the 1960's, bacterial chemotaxis has been predominantly studied as metabolism-independent. All available simulation models of bacterial chemotaxis endorse this assumption.
AM Stock, BL Taylor, BL Taylor, Christopher V. Rao, CS Vegge, D Bray, D Bray, D Stock, E Smith, Ezequiel A. Di Paolo, G Alexandre, G Alexandre, G Alexandre, GH Wadhams, GL Hazelbauer, GN Cohen-Ben-Lulu, H Morowitz, HC Berg, HC Berg, HL Packer, HR Maturana, I Sarand, I Zhulin, J Adler, J Letelier, J Stock, JC Edwards, JJ Falke, JL Spudich, JP Armitage, JS Parkinson, K Prasad, K Ruiz-Mirazo, M Eisenbach, M Eisenbach, Matthew D. Egbert, MD Egbert, MD Egbert, MJ Borrok, N Kresge, PA Thomason, R Barak, R Rosen, RA Goldstein, RK Clayton, RM Macnab, SA Kauffman, SA Kauffman, SE Greer-Phillips, SS Andrews, T Ganti, T Schweinitzer, VA Bespalov, WR Ashby, X Barandiaran, Xabier E. Barandiaran, XE Barandiaran, Y Jeziore-Sassoon, Y Sowa, Z Xie   +59 more
core   +5 more sources

Metabolic heat in microbial conflict and cooperation [PDF]

Frontiers in Ecology and Evolution 8:275 (2020), 2020
Many microbes live in habitats below their optimum temperature. Retention of metabolic heat by aggregation or insulation would boost growth. Generation of excess metabolic heat may also provide benefit. A cell that makes excess metabolic heat pays the cost of production, whereas the benefit may be shared by neighbors within a zone of local heat capture.
arxiv   +1 more source

Association between cognitive performance and cortical glucose metabolism in patients with mild Alzheimer's disease [PDF]

, 2005
Background: Neuronal and synaptic function in Alzheimer's disease (AD) is measured in vivo by glucose metabolism using positron emission tomography (PET). Objective: We hypothesized that neuronal activation as measured by PET is a more sensitive index of
A. Drzezga, A.L.W. Bokde, Baron JC, C. Born, Collins DL, G. Leinsinger, H. Hampel, H.-J. Moeller, Herholz K, Herscovitch P, Ibanez V, Ishii K, J. Thissen, Jueptner M, M. Schwaiger, McKhann G, Meltzer CC, Meltzer CC, Mentis MJ, Mentis MJ, P. Bartenstein, Pietrini P, Pietrini P, Pietrini P, Rapoport SI, S.J. Teipel, Sokoloff L, W. Dong   +27 more
core   +1 more source

MicroRNAs in metabolism and metabolic disorders [PDF]

Nature Reviews Molecular Cell Biology, 2012
MicroRNAs (miRNAs) have recently emerged as key regulators of metabolism. For example, miR-33a and miR-33b have a crucial role in controlling cholesterol and lipid metabolism in concert with their host genes, the sterol-regulatory element-binding protein (SREBP) transcription factors.
Veerle Rottiers, Anders M. Näär
openaire   +3 more sources

Global organization of metabolic fluxes in the bacterium, Escherichia coli [PDF]

Nature 427, 839-843 (2004), 2004
Cellular metabolism, the integrated interconversion of thousands of metabolic substrates through enzyme-catalyzed biochemical reactions, is the most investigated complex intercellular web of molecular interactions. While the topological organization of individual reactions into metabolic networks is increasingly well understood, the principles ...
arxiv   +1 more source

Amphiregulin Induces iNOS and COX-2 Expression through NF-κB and MAPK Signaling in Hepatic Inflammation

Mediators of Inflammation, 2023
Background. Inflammation is a major cause of hepatic tissue damage and accelerates the progression of nonalcoholic fatty liver disease (NAFLD). Amphiregulin (AREG), an epidermal growth factor receptor ligand, is associated with human liver cirrhosis and ...
Yu Jung Heo, Nami Lee, Sung-E. Choi, Ja Young Jeon, Seung Jin Han, Dae Jung Kim, Yup Kang, Kwan Woo Lee, Hae Jin Kim   +8 more
doaj   +1 more source

Cancer metabolism at a glance [PDF]

, 2016
A defining hallmark of cancer is uncontrolled cell proliferation. This is initiated once cells have accumulated alterations in signaling pathways that control metabolism and proliferation, wherein the metabolic alterations provide the energetic and ...
Gottlieb, Eyal, Kamphorst, Jurre J., Markert, Elke K., Schug, Zachary T., Tardito, Saverio, Vazquez, Alexei   +5 more
core   +2 more sources

Fructose Metabolism and Cardiac Metabolic Stress [PDF]

Frontiers in Pharmacology, 2021
Cardiovascular disease is one of the leading causes of mortality in diabetes. High fructose consumption has been linked with the development of diabetes and cardiovascular disease. Serum and cardiac tissue fructose levels are elevated in diabetic patients, and cardiac production of fructose via the intracellular polyol pathway is upregulated.
J. P. H. Neale, H. A. Ambalawanar, Kimberley M. Mellor, Kimberley M. Mellor, X. Li, A. H. L. Chau, Parisa Koutsifeli, Marco Annandale, L. J. Daniels, L. J. Daniels, L.M.D. Delbridge, S. L. James   +11 more
openaire   +6 more sources