Results 71 to 80 of about 2,371,969 (318)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Increased Central Artery Stiffness in Impaired Glucose Metabolism and Type 2 Diabetes [PDF]

, 2003
Miranda T. Schram, Ronald M.A. Henry, Rob A.J.M. van Dijk, Piet J. Kostense, Joost Dekker, Giel Nijpels, Robert J. Heine, L.M. Bouter, Nico Westerhof, Coen D.A. Stehouwer   +9 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Advanced Glycation End Products, Advanced Oxidation Protein Products, and Ferric Reducing Ability of Plasma Are Correlates of Uncontrolled Hypertension in Patients With Type 2 Diabetes

Journal of Diabetes Research
Conclusion: Oxidative stress indices are associated with HTN status and correlated with uncontrolled HTN in populations with T2D.
Seyed Arsalan Seyedi, Reihane Qahremani, Samira Amin Afshari, Armin Rajab, Amirhossein Yadegar, Fatemeh Mohammadi, Mostafa Shomalzadeh, Sahar Karimpour Reyhan, Hossein Mirmiranpour, Soghra Rabizadeh, Alireza Esteghamati, Manouchehr Nakhjavani   +11 more
doaj   +1 more source

Control of Cholesterol Metabolism and Plasma High-Density Lipoprotein Levels by microRNA-144 [PDF]

, 2013
Cristina M. Ramírez, Noemí Rotllán, Alexander V. Vlassov, Alberto Dávalos, Mu Li, Leigh Goedeke, Juan Aranda, Daniel Cirera‐Salinas, Elisa Araldi, Alessandro G. Salerno, Amarylis Wanschel, Jiří Zavadil, Antonio Castrillo, Jungsu Kim, Yajaira Suárez, Carlos Fernández‐Hernando   +15 more
openalex   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

The Metarhizium anisopliae Perilipin Homolog MPL1 Regulates Lipid Metabolism, Appressorial Turgor Pressure, and Virulence [PDF]

, 2007
Chengshu Wang, Raymond J. St. Leger
openalex   +1 more source

Selective autophagy of AKAP11 activates cAMP/PKA to fuel mitochondrial metabolism and tumor cell growth

, 2021
Zhiqiang Deng, Xianting Li, Marian Blanca Ramírez, Kerry Purtell, Insup Choi, Jiahong Lu, Qin Yu, Zhenyu Yue   +7 more
openalex   +2 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Metabolic-Bariatric Surgery: An Emerging Specialty

Proceedings of Singapore Healthcare, 2012
After the end of the second world war, the world saw a significant period of growth and prosperity unlike any previously. By the 1950s, morbid obesity was proving to be a clinical problem in many developed societies in Europe and North America.
S Pasupathy MBBS, FRCS (Ed), FRCS (Glas), Kwang Wei Tham MB, BCh, BAO, ABIM (Endocrinology, Diabetes and Metabolism)   +1 more
doaj   +1 more source