Results 201 to 210 of about 578,147 (248)

Icaritin Ameliorates Cisplatin‐Induced Mitochondrial Metabolic Dysfunction‐Associated Nephrotoxicity and Synergistically Potentiates Its Antitumor Efficacy

Advanced Science, EarlyView.
In this study, scRNA‐seq and chemoproteomics are integrated to characterize CDDP‐bound proteins at single‐cell resolution in tumor‐bearing mice. Additionally, the research demonstrates that ICA alleviates CDDP‐induced nephrotoxicity while enhancing its chemotherapeutic efficacy.
Piao Luo, Junhui Chen, Yehai An, Kun Meng, Wei Zhou, Wenhui Li, Jing Liu, Wentong Zhao, Weiyi He, Ting Cao, Jingnan Huang, Sha Feng, Shiguang Yang, Hongling Hu, Jiaxian Liao, Hengkai He, Mingjing Hao, Qian Zhang, Jigang Wang, Yue Gao   +19 more
wiley   +1 more source

Controlled Carbon Loss: Threshold-Dependent Overflow Metabolism in <i>Synechocystis</i> sp. PCC 6803. [PDF]

Microorganisms
Alford JT, Becker NS, Rapp J, Kulik A, Kaewbai-Ngam J, Monshupanee T, Link H, Forchhammer K.   +7 more
europepmc   +1 more source

Exercise mitigates the effects of a cafeteria diet on antidepressant-like behavior associated with plasma and microbial metabolites in adult male rats

M.H.C. Nota, Sarah Nicolas, Sebastian Dohm-Hansen, Erin P. Harris, Tara Foley, Olivia F. O’Leary, Yvonne M. Nolan   +6 more
openalex   +1 more source

De Novo TranscriptomeAnalysis Reveals Novel Insights into Secondary Metabolite Biosynthesis in Tylophora indica (Burm. f) Merrill [PDF]

Anamika Gupta, Deeksha Singh, Rajiv Ranjan   +2 more
openalex   +1 more source

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source

The Blood-Brain Barrier as an Integration Hub in Alzheimer's Disease: How Microbiota Metabolites Modulate Central Signal Processing. [PDF]

CNS Neurosci Ther
Giangiulio O, Maccarone R.
europepmc   +1 more source

Lactylated SPTAN1 Accelerates Hepatocellular Carcinoma Progression by Promoting NOTCH1/HES1 Activation and Immunosuppression

Advanced Science, EarlyView.
This study identifies SPTAN1‐kla as a novel oncogenic driver in HBV‐driven HCC, linking metabolic, epigenetic, and immune mechanisms. SPTAN1‐kla promotes HCC progression via NOTCH1/HES1 activation and immunosuppression. Findings highlight that targeting SPTAN1‐kla provides a framework for HCC treatment to improve clinical outcomes in HBV infected ...
Zengbin Wang, Dongjie Ye, Linqing Wu, Jiayu Liu, Banglun Pan, Zhu Zhang, Xiaoxia Zhang, Yuxin Yao, Nanhong Tang   +8 more
wiley   +1 more source

LC-MS-based metabolomic characterization of <i>Tinospora crispa</i> extracts: impact of solvent selection on phytochemical composition and antioxidant properties. [PDF]

RSC Adv
Muangritdech N, Prajumwongs P, Namwat N, Klanrit P, Wangwiwatsin A, Dokduang H, Sitthirak S, Titapun A, Loilome W.   +8 more
europepmc   +1 more source

The Current State of Knowledge About Changes in the Synthesis of the Secondary Metabolites Caused by Habitat Conditions and Microbial Activity [PDF]

Barbara Bacler-Żbikowska, Agnieszka Hutniczak, Barbara Pilawa, Ewa Chodurek, Magdalena Zdybel, Anna Piekarska‐Stachowiak, Dea Fatmawati, Leszek Malinowski, Gabriela Woźniak   +8 more
openalex   +1 more source

Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR‐Dependent Translational Control of Synaptic Proteins

Advanced Science, EarlyView.
Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren, Renhe Cao, Xiaoshan Ye, Wenbin Pang, Qingshang Bi, Meihui Huang, Qionglin Zhou, Dan Ye, Wei Xiang, Le Xiao   +9 more
wiley   +1 more source